known as JNK1) is a ubiquitous enzyme that in humans is encoded by the MAPK8 gene. The protein encoded by this gene is a member of the MAP kinase and...
16 KB (1,781 words) - 00:37, 15 June 2024
superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members...
18 KB (1,937 words) - 21:50, 5 January 2024
phosphorylated and ubiquitinated. ITCH is regulated by MAPK8. MAPK8 regulates JUNB protein turnover by MAPK8-dependent phosphorylation of ITCH and a subsequent...
9 KB (1,030 words) - 07:11, 3 April 2024
signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC...
65 KB (7,149 words) - 04:45, 26 August 2024
MAP kinase kinase kinase kinase MAPK1 (ERK2) MAPK3 (ERK1) MAPK7 (ERK5) MAPK8 (JNK1) MAPK9 (JNK2) MAPK10 (JNK3) MAPK11 (p38-beta) MAPK12 (p38-gamma) MAPK13...
46 KB (5,492 words) - 14:52, 20 August 2024
of binding. MEKK1 activates MAPK8/JNK by phosphorylation of its activator SEK1(MAP2K4). MAP3K3 directly regulates the MAPK8/JNK and extracellular signal-regulated...
11 KB (1,345 words) - 09:11, 2 January 2024
kinases in response to various environmental stresses or mitogenic stimuli. MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38 are substrates for MAP2K4, but MAPK1/ERK2...
9 KB (1,031 words) - 06:03, 11 March 2024
signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC...
69 KB (7,803 words) - 11:01, 11 April 2024
to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and...
13 KB (1,424 words) - 04:47, 27 January 2024
cytokines, and environmental stresses. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated...
23 KB (2,694 words) - 17:22, 17 July 2024
This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2, TRAF3, and TRAF5 have been shown to mediate...
10 KB (1,133 words) - 04:35, 22 December 2023
signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC...
14 KB (1,385 words) - 10:32, 28 April 2024
signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC...
48 KB (5,285 words) - 16:26, 21 August 2024
ACTL6A BRCA1 Bcl-2 Cyclin T1 CHD8 DNMT3A EP400 GTF2I HTATIP let-7 MAPK1 MAPK8 MAX MLH1 MYCBP2 MYCBP NMI NFYB NFYC P73 PCAF PFDN5 RuvB-like 1 SAP130 SMAD2...
57 KB (6,717 words) - 23:11, 17 August 2024
mitogen-activated protein kinase 8 Identifiers Symbol MAPK8 Alt. symbols JNK1, PRKM8 NCBI gene 5599 HGNC 6881 OMIM 601158 RefSeq NM_002750 UniProt P45983...
14 KB (1,626 words) - 20:50, 30 May 2024
signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC...
49 KB (5,773 words) - 16:32, 11 September 2024
been shown to interact with Fanconi anemia, complementation group C and MAPK8. GST-Pi is expressed in many human tissues, particularly in the biliary...
5 KB (628 words) - 00:29, 4 March 2023
signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC...
35 KB (3,829 words) - 14:24, 17 June 2024
HGNC:6878 P31152 9233 MAPK6 HGNC:6879 Q16659 9234 MAPK7 HGNC:6880 Q13164 9235 MAPK8 HGNC:6881 P45983 9236 MAPK8IP1 HGNC:6882 Q9UQF2 9237 MAPK8IP2 HGNC:6883...
277 KB (17 words) - 15:46, 9 May 2024
signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC...
35 KB (3,831 words) - 18:08, 20 August 2024
signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC...
14 KB (1,447 words) - 09:31, 22 December 2023
signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC...
27 KB (2,716 words) - 12:30, 12 September 2024
Like MAP4K4 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 MAPK8 JNK1 Mitogen-Activated Protein Kinase 8 MAPRE1 MAPRE1 Microtubule-associated...
183 KB (12,458 words) - 20:40, 1 July 2024
signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC...
119 KB (12,654 words) - 00:05, 31 July 2024
MAPK11 ; MAPK12 ; MAPK13 ; MAPK14 ; MAPK15 ; MAPK3 ; MAPK4 ; MAPK6 ; MAPK7 ; MAPK8 ; MAPK9 ; MAPKAPK2 ; MAPKAPK3 ; MAPKAPK5 ; MARK1 ; MARK2 ; MARK3 ; MARK4 ;...
17 KB (1,559 words) - 03:23, 25 May 2024
signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC...
57 KB (6,278 words) - 21:51, 24 August 2024
signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC...
3 KB (296 words) - 17:06, 14 September 2023
signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC...
27 KB (2,665 words) - 17:03, 6 April 2024
signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC...
8 KB (886 words) - 12:46, 31 January 2024
signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC...
35 KB (4,314 words) - 00:26, 6 July 2024