12 homolog (S. cerevisiae), also known as MED12, is a human gene found on the X chromosome. Mutations in MED12 are responsible for at least two different...

most common of the types, and is found in the MED12 gene. Known types and affected genes include: The MED12 gene codes for the mediator complex subunit...

attributed to a missense mutation in the MED12 gene. There is currently no treatment or therapy for the underlying MED12 malfunction, and the exact cause of...

harbor mutations in the exon (exon 2) of the mediator complex subunit 12 (MED12) gene. In particular, these mutations are restricted to the stromal component...

80–85% of fibroids have a mutation in the mediator complex subunit 12 (MED12) gene. A syndrome (Reed's syndrome) that causes uterine leiomyomata along...

to regulate gene expression in vivo, and are prevented by mutations in MED12 that produce the human disease FG syndrome. Thus, the structure of a mediator...

higher incidence of phyllodes tumors include Mediator Complex Subunit 12 (MED12) exon 2, Telomerase Reverse Transcriptase (TERT) promoter, and Retinoic...

MFAP5, TGFB2, SMAD4, MYH11 dominant Feingold syndrome MYCN FG syndrome MED12 FBXW7 neurodevelopmental syndrome FBXW7 Fibular aplasia-ectrodactyly syndrome...

HGNC:25487 Q9NWA0 9408 MED10 HGNC:28760 Q9BTT4 9409 MED11 HGNC:32687 Q9P086 9410 MED12 HGNC:11957 Q93074 9411 MED12L HGNC:16050 Q86YW9 9412 MED13 HGNC:22474 Q9UHV7...

many other factors which will affect transcription activation: BAG1, CAV3, MED12, MED24, NCOR1, NCOR2, NCOA2 RXRA, RUNX1, RUNX1T1, SNW1, STAT1, and ZBTB16...

Oculodentodigital dysplasia 164200 GJA1 Optiz–Kaveggia syndrome 305450 MED12 Otopalatodigital syndrome 2 304120 FLNA Periventricular heterotopia X‐linked...

modules in regulating T cell effector differentiation and demonstrated that MED12 knockout increased the potency of human T cells in preclinical models. Mackall...

EP300 ESR2 FOXO1 GREB1 GTF2H1 HSPA1A HSPA8 HSP90AA1 ISL1 JARID1A MVP MED1 MED12 MED14 MED16 MED24 MED6 MGMT MNAT1 MTA1 NCOA6 NCOA1 NCOA2 NCOA3 NRIP1 PDLIM1...

complex of Mediator proteins (see Figure), especially Mediator subunit 12 (MED12), appears to be essential in forming the chromosome loop that brings the...

Garraway LA (Jun 2012). "Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer". Nature Genetics. 44 (6): 685–9. doi:10.1038/ng...

estrogen-related receptor gamma (ERR-γ). Farnesoid X receptor FBXW7 MED1, MED12, MED14, MED17, NRF1 Peroxisome proliferator-activated receptor gamma Retinoid...

in males. SOX9 has been shown to interact with steroidogenic factor 1, MED12, MAF, SWI/SNF, MLL3 and MLL4. Loss of function mutations with Sox9 can lead...

complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator...

611818; CAV3 Lowe syndrome; 309000; OCRL Lujan–Fryns syndrome; 309520; MED12 Lung cancer; 211980; DLEC1 Lung cancer; 211980; RASSF1 Lung cancer; 211980;...

THR1 has been shown to interact with: COPS2, EP300, ITGB3BP, MED1, MED6, MED12, MED16, MEF2A, NCOA6, TRIP11, and UBC. GRCh38: Ensembl release 89: ENSG00000126351...

8 has been shown to interact with: CCNC CREB binding protein CRSP3 MED1 MED12 MED14 MED16 MED17 MED21 MED24 MED26 MED6 Notch proteins POLR2A SMARCB1 STAT1...

has been shown to interact with MED8, Cyclin-dependent kinase 8, POLR2A, MED12 and MED28. It also acts synergistically to mediate the interaction between...

Modification of signaling pathways and genes (e.g. CYP1A1, CYP1b1, and MED12) exhibits a correlation with the development and growth of tumors in the...