(GDC-0980) is a PI3K inhibitor (subunits α, δ, and γ) that also targets mTORC There are numerous cell signalling pathways that exhibit cross-talk with...

than the mTORC1 signaling pathway. The functions of the components of the mTORC complexes have been studied using knockdowns and knockouts and were found...

inhibitor) and everolimus (mTORC inhibitor) for the treatment of NF1 plexiform neurofibromas, sirolimus (rapamycin) (mTORC inhibitor) for MPNSTs, or lovastatin...

gonadal hormones underlie male-specific improvements in glucose tolerance and mTORC 2 signaling". Aging Cell. 16 (6): 1256–1266. doi:10.1111/acel.12656. ISSN 1474-9718...

restriction inhibits mTORC1 signaling through both upstream pathways of mTORC that converge on the lysosome. Autophagy is the major degradation pathway...

counterpart called cTORC to explain why cancer therapies targeting only mTORC have been unsuccessful. "Platanias Receives AHEPA Academy of Achievement...

and prostate cancer cell lines and tissues. Knockdown of mLST8 prevented mTORC formation and inhibited tumor growth and invasiveness. GRCh38: Ensembl release...

oncoprotein caused an upregulation of mTORC1 (Sanden et al., 2013). Thus, a mTORC inhibitor could be a potential treatment. "Acute Myeloid Leukemia - Signs...

affect expression of NFE2L1 through a mTORC and SREBP-1 mediated pathway. Growth factors induce higher activity of mTORC, which then promotes activity of its...