miR-122 is a miRNA that is conserved among vertebrate species. miR-122 is not present in invertebrates, and no close paralogs of miR-122 have been detected...

clinical trials as of 2017. It is antisense to a human microRNA called miR-122. miR-122 ferries an argonaute protein to 5'-UTR region of viral RNA, where it...

prior to miR-456. A capitalized "miR-" refers to the mature form of the miRNA, while the uncapitalized "mir-" refers to the pre-miRNA and the pri-miRNA. The...

246 mph) and maximum range of 32 km (20 mi). It is used primarily by the Indonesian military. The R-Han 122 was made by PT Dirgantara Indonesia (PT DI...

to develop and commercialize microRNA therapeutics targeting microRNA-122 (miR-122) for the treatment of hepatitis C (HCV) infection. Most recently,[when...

15-nucleotide phosphorothioate sequence with binding specificity for MiR-122 (a miRNA expressed in hepatocytes). Allele-specific PCR using LNA allows for...

Up-regulated Modulator of Apoptosis (PUMA). When the viral mir-BART5 was depleted using its anti-miRNA, anti-miR-BART5, cell apoptosis was triggered and resulted...

Potential binding sites for mir-33 have been identified in the cDNA of tumour suppressor p53. Further, study has shown that miR-33 is able to repress p53...

treating many other diseases. Antagomirs were first developed to target miR-122, a microRNA that was abundant and specific to the liver, and this discovery...

of the BRAF oncogene. Hepatitis C has shown been suggested to regulate miR-122 through be a ceRNA mechanism when overexpressed in Huh-7.5 cells. It however...

(2014). "MiR-148a- and miR-216a-regulated Oncolytic Adenoviruses Targeting Pancreatic Tumors Attenuate Tissue Damage Without Perturbation of miRNA Activity"...

his early tenure at Stanford, Sarnow and his research team identified miR-122 as a necessary mechanism to cause the hepatitis C virus uses to replicate...

example is RNA interference (RNAi), in which endogenously expressed microRNA (miRNA) or exogenously derived small interfering RNA (siRNA) induces the degradation...

(MI0000156, MI0000408), and in human (MI0000448, MI0000748). miR-130 appears to be vertebrate-specific miRNA and has now been predicted or experimentally confirmed...

DR, Lemon SM (January 2013). "Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication"...

Rosenquist, who was camping 11 mi (18 km) away from the blast 46°18′49″N 122°02′12″W / 46.31361°N 122.03667°W / 46.31361; -122.03667. Rosenquist, his party...

The 122-mm howitzer D-30 (GRAU index 2A18) is a Soviet howitzer that first entered service in 1960. It is a robust piece that focuses on the essential...

multi-purpose chassis, mounting a 122 mm 2A18 howitzer. "2S1" is its GRAU designation. An alternative Russian designation is SAU-122, but in the Russian Army it...

122 mm corps gun M1931/37 (A-19) (Russian: 122-мм корпусная пушка обр. 1931/1937 гг. (А-19)) was a Soviet field gun developed in late 1930s by combining...

The 122 mm howitzer M1938 (M-30) (GRAU index: 52-G-463) is a Soviet 121.92 mm (4.8 inch) howitzer. The weapon was developed by the design bureau of Motovilikha...

The new carrier vehicle provides enough space for carrying 40 additional 122 mm rockets pack for automatic reload. Nevertheless, RM-70 performance remains...

598 kg/m2 (122 lb/sq ft) Thrust/weight: 0.55 at gross weight Armament Missiles: 4 × R-40R/T air-to-air missiles with 8 g launch overload 4 × R-40RD/TD air-to-air...

Pogribny I, Frankel W, Jacob ST, Ghoshal K (October 2006). "Downregulation of miR-122 in the rodent and human hepatocellular carcinomas". Journal of Cellular...

for experienced MiG-23 pilots, while combat manuals continued to emphasize the 45° position. The MiG-23's original engine was a 122 kN (12,500 kgf; 27...

Lerro A, Buendia MA, Xu C, Mason WS, Moloshok T, Bort R, Zaret KS, Taylor JM (2004). "miR-122, a mammalian liver-specific microRNA, is processed from...

underwater. The carrier and command centre of both Mir submersibles is the R/V Akademik Mstislav Keldysh. The two Mir units are operated by the Russian Academy...

Suvendra N Bhattacharyya (May 2014). "Insulin-like growth factor-1 prevents miR-122 production in neighbouring cells to curtail its intercellular transfer...

(SPC3649), which entered Phase II clinical trials in 2010. The drug targets miR-122, a host factor necessary for viral replication of the hepatitis C virus...

Tiger I between 100 and 300 m (0.062 and 0.186 mi) at the driver's front plate and nose, while the IS-2's 122 mm gun would penetrate the Tiger's front armor...

million by the Jagat Seths). The victory was made possible by the defection of Mir Jafar, Nawab Siraj-ud-Daulah's commander in chief who was also paid by the...