The mutation accumulation theory of aging was first proposed by Peter Medawar in 1952 as an evolutionary explanation for biological aging and the associated...

body from the environment or resulting from cell metabolism. Mutation accumulation theory was first proposed by Peter Medawar in 1952 as an evolutionary...

catastrophe, somatic mutation, accumulation of genetic material (DNA) damage (DNA damage theory of aging) and dysdifferentiation. The system theories include the...

variability in the lifespans of organisms. The classical theories of evolution (mutation accumulation, antagonistic pleiotropy, and disposable soma) suggest...

The DNA damage theory of aging proposes that aging is a consequence of unrepaired accumulation of naturally occurring DNA damage. Damage in this context...

increases the accumulation of mutation load, culminating in extinction via mutational meltdown. The accumulation of deleterious mutations in humans has...

neutral mutation is one that does not affect an organism's ability to survive and reproduce. The neutral theory assumes that most mutations that are...

neutral mutations has led to the development of the neutral theory of molecular evolution, which is an important and often-controversial theory that proposes...

A mutation accumulation (MA) experiment is a genetic experiment in which isolated and inbred lines of organisms (so-called MA lines) are maintained such...

genomes frequently have AT-biased mutation. Contemporary thinking about the role of mutation biases reflects a different theory from that of Haldane and Fisher...

and potentially all living domains... ". Evolution of ageing Mutation accumulation theory Williams GC (1957). "Pleiotropy, natural selection, and the evolution...

confused with the concept of an error catastrophe) is the accumulation of harmful mutations in a small population, which leads to loss of fitness and...

In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain...

lifespans and earlier reproductive periods. Classical theories of aging include: Mutation Accumulation Theory of Aging - Because extrinsic mortality is so high...

due to accumulation of mutations and decreases in response to natural selection and genetic drift. Mutation accumulation occurs when mutations of small...

characterizing the mutation rate is the mutation accumulation line. Mutation accumulation lines have been used to characterize mutation rates with the Bateman-Mukai...

generation to the next, and the random occurrence of mutations in these alleles. The mathematical theory of the coalescent was developed independently by...

to use the MA (mutation accumulation) method and high-throughput sequencing (e.g., ). Cases of mutation bias are cited by mutationism advocates of the...

original idea involving mutation "by random change and a form of Darwinian selection". Internet memes are an example of Dawkins' meme theory at work in the sense...

Aging Mutation accumulation theory of aging Neuroendocrine theory of aging Order to disorder theory of aging Rate of living theory Redundant DNA theory Reliability...

international interaction is necessary. 1952 Peter Medawar proposed the mutation accumulation theory to explain how the aging process could have evolved. 1954 Vladimir...

in an accumulation of irreversible deleterious mutations. This happens because in the absence of recombination, and assuming reverse mutations are rare...

the first to suggest that the combined effects of parasitism and mutation accumulation can lead to an increased advantage to sex under conditions not otherwise...

result of a single, isolated event, rather than the slow accumulation of multiple mutations. The exact function of some tumor suppressor genes is not...

his mathematical evolutionary theory of the quasispecies. The term is most widely used to refer to mutation accumulation to the point of inviability of...

Goldschmidt believed that the neo-Darwinian view of gradual accumulation of small mutations was important but could account for variation only within species...

organs. According to the prevailing accepted theory of carcinogenesis, the somatic mutation theory, mutations in DNA and epimutations that lead to cancer...

Butlin RK, Bank C (March 2021). Buerkle A (ed.). "Deleterious mutation accumulation and the long-term fate of chromosomal inversions". PLOS Genetics...

needed for deterministic loss by mutation accumulation. In both cases, the time to fixation is dominated by mutation via the term ⁠1/m⁠, and is less affected...

maintenance, leading to increased cellular damage, shortened telomeres, accumulation of mutations, compromised stem cells, and ultimately, senescence. Although...