Myostatin inhibitors are a class of drugs that work by blocking the effects of myostatin, which inhibits muscle growth. In animal models and limited human...
11 KB (1,195 words) - 00:18, 21 June 2024
cells to inhibit muscle growth. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family. Myostatin is assembled...
48 KB (5,338 words) - 01:58, 13 October 2024
Sarcopenic obesity (section Myostatin Inhibitors)
mass. Myostatin is a protein found on muscle cells that inhibit the growth of muscles. Elderly patients are known to have higher levels of myostatin compared...
30 KB (3,722 words) - 14:05, 19 September 2024
Apitegromab (category Myostatin inhibitors)
1 Safety, Pharmacokinetic and Pharmacodynamic Study of the Novel Myostatin Inhibitor Apitegromab (SRK-015): A Potential Treatment for Spinal Muscular...
5 KB (259 words) - 10:47, 12 November 2023
Creatine (category Myostatin inhibitors)
Creatine (/ˈkriːətiːn/ or /ˈkriːətɪn/) is an organic compound with the nominal formula (H2N)(HN)CN(CH3)CH2CO2H. It exists in various tautomers in solutions...
61 KB (6,637 words) - 04:14, 21 October 2024
Follistatin (category Myostatin inhibitors)
Hasegawa Y, et al. (February 2008). "Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates...
19 KB (2,169 words) - 14:40, 2 September 2024
Stamulumab (category Myostatin inhibitors)
Stamulumab (MYO-029) is an experimental myostatin inhibiting drug developed by Wyeth Pharmaceuticals for the treatment of muscular dystrophy (MD). Stamulumab...
6 KB (524 words) - 13:17, 19 August 2024
of Medicine. Lee SJ, Gharbi A, Shin JE, Jung ID, Park YM (2021). "Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis". Biochemical...
74 KB (6,780 words) - 06:22, 16 October 2024
; McPherron, Alexandra C. (October 2011). "Expression and Function of Myostatin in Obesity, Diabetes, and Exercise Adaptation". Medicine and Science in...
4 KB (392 words) - 16:16, 16 September 2024
PMID 23995658. Lee SJ, Gharbi A, Shin JE, Jung ID, Park YM (March 2021). "Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis". Biochemical...
4 KB (239 words) - 14:39, 6 June 2024
prevent Axl activation. ACE-031 is an engineered decoy receptor and myostatin inhibitor used in attempts to treat children with Duchenne muscular dystrophy...
6 KB (686 words) - 02:37, 26 February 2022
Activin type 2 receptors (section Inhibitors)
plays a role in non-MSI-H colorectal cancers. Stamulumab (MYO-029) myostatin Inhibitor Lee SJ, Reed LA, Davies MV, Girgenrath S, Goad ME, Tomkinson KN,...
6 KB (583 words) - 15:40, 29 March 2023
including clomiphene, cyclofenil, and fulvestrant Myostatin modifying agents, including myostatin inhibitors (e.g., follistatin) Metabolic modifying agents...
9 KB (700 words) - 21:23, 1 October 2024
activin type 2 receptors-signalling proteins myostatin and activin A via activin A/myostatin inhibitor ACVR2B – tested preliminarily in humans in the...
206 KB (19,725 words) - 21:16, 12 September 2024
the myostatin gene which codes for the protein, myostatin ("myo" meaning muscle and "statin" meaning stop). Myostatin is a protein that inhibits muscle...
11 KB (1,226 words) - 01:20, 14 September 2024
the Treatment of Adults and Adolescents with Hemophilia A or B Without Inhibitors" (Press release). Pfizer. 11 October 2024. Retrieved 12 October 2024 –...
137 KB (4,083 words) - 21:25, 19 October 2024
Bimagrumab (category Myostatin inhibitors)
et al. (June 2018). "Effects of bimagrumab, an activin receptor type II inhibitor, on pituitary neurohormonal axes". Clinical Endocrinology. 88 (6): 908–919...
5 KB (365 words) - 20:04, 20 December 2023
Garetosmab (category Myostatin inhibitors)
Garetosmab is a fully human, experimental monoclonal antibody against activin-A. It has been tried in patients with fibrodysplasia ossificans progressiva...
5 KB (264 words) - 20:14, 9 May 2024
A.; Liu, Yewei; Germain-Lee, Emily L. (22 September 2020). "Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight"...
152 KB (27,252 words) - 16:36, 5 October 2024
activin type 2 receptors-signalling proteins myostatin and activin A via activin A/myostatin inhibitor ACVR2B – tested preliminarily in humans in the...
280 KB (24,498 words) - 09:15, 5 October 2024
"Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin...
4 KB (508 words) - 02:02, 19 August 2023
effects. Myocytes use myostatin to tell each other to inhibit myogenesis. Melanocyte-inhibiting factor (melanostatin) inhibits release of other neuropeptides...
6 KB (652 words) - 09:36, 4 July 2023
fulvestrant, and all other anti-estrogenic substances are banned. Myostatin inhibitors are banned. Metabolic modulators including peroxisome proliferator-activated...
20 KB (1,821 words) - 22:04, 12 September 2024
Anti-Müllerian hormone (redirect from Mullerian inhibiting hormone)
Anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting hormone (MIH), is a glycoprotein hormone structurally related to inhibin and activin from...
41 KB (4,835 words) - 00:58, 10 October 2024
inhibition of B cell proliferation. It is also known to induce NF-κB inhibitor IKBa, inhibiting NF-κB activation. NF-κB is a transcription factor that regulates...
70 KB (8,486 words) - 02:10, 19 August 2024
SB-431542 (category Protein kinase inhibitors)
GlaxoSmithKline (GSK) as an inhibitor of the activin receptor-like kinase (ALK) receptors, ALK5, ALK4 and ALK7. However, it is not an inhibitor of anaplastic lymphoma...
4 KB (326 words) - 07:53, 18 May 2024
alfa Kinase inhibitors: DMH-2 Dorsomorphin (BML-275) K-02288 ALK4 (ACVR1B) Agonists: Activin (A, B, AB) GDF (1, 3, 11 (BMP11)) Myostatin (GDF8) Nodal...
7 KB (595 words) - 13:39, 10 September 2024
BAMBI (redirect from Bone and Activin membrane bound inhibitor)
(2004). "Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of...
7 KB (930 words) - 01:40, 6 September 2023
homologue, antivin, in zebrafish show that Lefty likely acts as a competitive inhibitor of Nodal signaling. Overexpression of Lefty leads to a phenotype similar...
27 KB (3,398 words) - 18:33, 6 July 2024