N1-Methylpseudouridine (abbreviated m1Ψ) is a natural archaeal tRNA component, and "hypermodified" pyrimidine nucleoside used in biochemistry and molecular...
16 KB (1,511 words) - 00:10, 7 October 2024
nucleoside substitutions such as 5-methylcytosine, 5-methyluridine, N1-methylpseudouridine (the same nucleoside used in the Moderna and Pfizer/Biontech COVID...
13 KB (1,425 words) - 07:08, 29 October 2024
termed the "T-loop motif". In archaea, the m5U is replaced with N1-methylpseudouridine (m1Ψ). The m5U/m1Ψ modification at position 54 is thought to increase...
3 KB (427 words) - 15:11, 16 October 2024
U's have been substituted with N1-methylpseudouridine, a nucleoside related to Ψ that contains a methyl group added to N1 atom. Ψ is found in the large...
24 KB (2,835 words) - 06:46, 28 July 2024
delivered by the vaccine. Non-amplifying vaccines replace uridine with N1-Methylpseudouridine in an attempt to reduce toxicity. Self-amplifying mRNA (saRNA) vaccines...
77 KB (7,878 words) - 16:22, 10 October 2024
the immunogenicity of mRNA therapies, i.e. the introduction of N1-methylpseudouridine, a solution that made possible the development of mRNA vaccines...
53 KB (5,090 words) - 14:57, 6 November 2024
1-methylpseudouridine at position 54 of tRNA". RNA. 18 (3): 421–33. doi:10.1261/rna.030841.111. PMC 3285931. PMID 22274953. TRNA+(pseudouridine54-N1)-methyltransferase...
2 KB (217 words) - 16:07, 26 August 2023
sequence is further optimized by: all uridines (U) substituted with N1-methylpseudouridine (U → m1Ψ), flanked by an artificial 5' untranslated region (UTR)...
177 KB (13,698 words) - 16:52, 23 October 2024
De Smedt SC, Weiss R, Sanders NN, Kitada T (November 2015). "N(1)-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by...
24 KB (2,503 words) - 11:29, 22 February 2024