Endonuclease VIII-like 1 is an enzyme that in humans is encoded by the NEIL1 gene. NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial...

human NEIL1 appear to be the hydantoin lesions, guanidinohydantoin, and spiroiminodihydantoin that are further oxidation products of 8-oxoG. NEIL1 is also...

“cowcatcher” to slow replication until NEIL1 can act as a glycosylase and remove the oxidatively damaged base. NEIL1 protein recognizes (targets) and removes...

water maze. Endonuclease VIII-like 1 (NEIL1) is a DNA repair enzyme that is widely expressed throughout the brain. NEIL1 is a DNA glycosylase that initiates...

LIG4 occurs in 82% of colorectal cancers and epigenetic downregulation of NEIL1 occurs in 62% of head and neck cancers and in 42% of non-small-cell lung...

repair genes BRCA1, WRN, FANCB, FANCF, MGMT, MLH1, MSH2, MSH4, ERCC1, XPF, NEIL1 and ATM. These epigenetic defects occurred in various cancers, including...

monofunctional uracil-DNA glycosylase 1 (SMUG1), Nei-Like DNA Glycosylase 1 (NEIL1), or methyl-CpG binding protein 4 (MBD4). AP sites and T:G mismatches are...

Gene Frequency of hyper- (or hypo-) methylation DNA repair pathway Ref. NEIL1 42% base excision repair WRN 38% homologous recombinational repair, nonhomologous...

LIG4 occurs in 82% of colorectal cancers. Promoter hypermethylation of NEIL1 occurs in 62% of head and neck cancers and in 42% of non-small-cell lung...

screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma". Oncogene. 31 (49): 5108–16. doi:10...

WRN associates with NEIL1 in the early damage-sensing step of BER. WRN stimulates NEIL1 in excision of oxidative lesions. NEIL1 is a DNA glycosylase...

from the original on October 2, 2022. Retrieved November 5, 2020. Warwick, Neil1; Jon Kutner, Tony Brown (2004). The Complete Book of the British Charts:...

monofunctional uracil-DNA glycosylase 1 (SMUG1), Nei-Like DNA Glycosylase 1 (NEIL1), or methyl-CpG binding protein 4 (MBD4). AP sites and T:G mismatches are...

image). Both 8-oxo-dG and formamidopyrimidine are mutagenic. DNA glycosylase NEIL1 prevents mutagenesis by 8-oxo-dG and removes formamidopyrimidines from DNA...

monofunctional uracil-DNA glycosylase 1 (SMUG1), Nei-Like DNA Glycosylase 1 (NEIL1), or methyl-CpG binding protein 4 (MBD4). AP sites and T:G mismatches are...

[citation needed] That review also indicated promoter hypermethylation of LIG4, NEIL1, ATM, MLH1 or FANCB occurs at frequencies between 33% and 82% in one or...

5mC can be converted to thymine (Thy). 5hmU can be cleaved by TDG, SMUG1, NEIL1, or MBD4. AP sites and T:G mismatches are then repaired by base excision...

protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1". J. Biol. Chem. 282 (36): 26591–602. doi:10.1074/jbc.M703343200. PMID 17611195...

cancers. In addition, promoter hypermethylation of DNA repair genes LIG4, NEIL1, ATM, MLH1 or FANCB occurs at frequencies of between 33% and 82% in one...

introducing a DNA strand break via the associated lyase reaction. OGG1 NTHL1 NEIL1 NEIL2 GRCh38: Ensembl release 89: ENSG00000109674 – Ensembl, May 2017 GRCm38:...

5mC can be converted to thymine (Thy). 5hmU can be cleaved by TDG, MBD4, NEIL1 or SMUG1. AP sites and T:G mismatches are then repaired by base excision...

P07196 10424 NEFM HGNC:7734 P07197 10425 NEGR1 HGNC:17302 Q7Z3B1 10426 NEIL1 HGNC:18448 Q96FI4 10427 NEIL2 HGNC:18956 Q969S2 10428 NEIL3 HGNC:24573 Q8TAT5...

in genes BRCA1, WRN, FANCB, FANCF, MGMT, MLH1, MSH2, MSH4, ERCC1, XPF, NEIL1 and ATM located in cancers including breast, ovarian, colorectal and head...

regeneration and repair. In particular, she studies the proteins MUTYH and NEIL1, which help to catalyze the repair of damaged DNA as part of the base excision...

Aaron M.; Burrows, Cynthia J.; Wallace, Susan S. (2013-09-20). "Neil3 and NEIL1 DNA glycosylases remove oxidative damages from quadruplex DNA and exhibit...

screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma". Oncogene. 31 (49): 5108–5116...

causes a cancer susceptibility syndrome similar to Lynch syndrome. OGG1 NEIL1 NEIL2 NEIL3 GRCh38: Ensembl release 89: ENSG00000065057 – Ensembl, May 2017...

pigmentosum, resulting in xeroderma pigmentosum-cockayne syndrome (XP-CS). OGG1 NEIL1 NEIL2 Endonuclease AP endonuclease "Homo sapiens GO:0003906 - DNA-(apurinic...

that are responsible for repairing specific nucleotide lesions, e.g. Human NEIL1 DNA glycosylase, thymine DNA glycosylase, 8-oxoguanine DNA glycosylase (OGG1)...

the associated lyase reaction (Bandaru et al., 2002)[supplied by OMIM] NEIL1 NEIL3 OGG1 NTHL1 GRCm38: Ensembl release 89: ENSMUSG00000035121 – Ensembl...