Netrin-1 is a protein that in humans is encoded by the NTN1 gene. Netrin is included in a family of laminin-related secreted proteins. The function of...

Netrins are a class of proteins involved in axon guidance. They are named after the Sanskrit word "netr", which means "one who guides". Netrins are genetically...

Netrin receptor DCC, also known as DCC, or colorectal cancer suppressor is a protein which in humans is encoded by the DCC gene. DCC has long been implicated...

for netrins including UNC-6. Netrins are a class of proteins involved in axon guidance. UNC-5 uses repulsion to direct axons while the other netrin receptor...

Holt C (September 1999). "Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1". Nature. 401 (6748): 69–73. Bibcode:1999Natur.401...

with netrin-1 loss-of-function exhibit severe disruption in commissural axon migration; this experiment established the importance of Netrin-1 in guidance...

rodents in 1994 have determined that netrins are vital to guidance cues. The vertebrate orthologue of UNC-6, netrin-1 was determined to be a key guidance...

immunohistochemistry protocol for detecting the guidance cue Netrin-1 in neural tissue". MethodsX. 5: 1–7. doi:10.1016/j.mex.2017.12.001. PMC 5737949. PMID 29276694...

attracted by Netrin and repelled by Slit. However, as axons approach the midline, the repellent action of Slit is suppressed by Robo-3/Rig-1 receptor. Once...

response in organisms, Tetrahymena thermophila adapt to a chemorepellent, Netrin-1 peptide, within 10 minutes of exposure; however, exposure to chemorepellents...

netrin 1 and reelin. These and other integrin beta 1 complexes have been historically known as very late activation (VLA) antigens. Integrin beta 1 is...

Netrin-G1 is a protein that in humans is encoded by the NTNG1 gene. Netrin G1 (NTNG1) belongs to a conserved family of proteins that act as axon guidance...

transfection of Netrin-1 and Netrin-2, two secreted proteins, into Cos cells has similar effects. Further research confirmed that Netrins act as attractant...

Netrin-5 (NTN5), also known as netrin-1-like protein, is a protein that in humans is encoded by the NTN5 gene. Netrin-5 is included in the family of secreted...

is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance". Cell. 113 (1): 11–23. doi:10.1016/S0092-8674(03)00199-5. PMID 12679031...

depending on context. A prime example of this is Netrin-1, which signals attraction through the Netrin receptor DCC and repulsion through the UNC-5 receptor...

account for about 35 percent of cases. In DCC mutation, impaired or missing netrin 1 receptor protein impairs control of axon growth during nervous system development...

(also a potential site of tyrosine phosphorylation and binds P3 domain of netrin-1 receptor DCC), CC2 (polyproline stretch; consensus binding site for Ena/Vasp...

Netrin receptor UNC5A is a protein that in humans is encoded by the UNC5A gene. UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to...

whereas in the presence of their netrin-1 ligand, they transduce classical "positive" signals, in the absence of netrin-1, they actively trigger apoptosis...

tumor microenvironment can also be targeted by radioimmunotherapy, such as Netrin-1 (an axon guidance protein) and FAP (a marker for cancer associated fibroblasts)...

Delloye-Bourgeois, Céline; Chédotal, Alain (2011). "Novel roles for Slits and netrins: Axon guidance cues as anticancer targets?". Nature Reviews Cancer. 11...

and RAD51 (recombination protein A). DCC encodes a receptor for NTN1 (netrin-1), a protein thought to be responsible for axon guidance and neuronal cell...

studies have found that netrin-1, DCC, and laminin-1 are key players in axon guidance from the retina. For example, netrin-1 is both a chemoattractant...

activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. Similarly to A2A receptor, the A2B...

Molecular Biology. Vol. 714. pp. 103–123. doi:10.1007/978-1-61779-005-8_7. ISBN 978-1-61779-004-1. PMID 21431737. Graus, F.; Ferrer, I. (1990). "Analysis...

Netrin-G2 is a protein that in humans is encoded by the NTNG2 gene. GRCh38: Ensembl release 89: ENSG00000196358 – Ensembl, May 2017 GRCm38: Ensembl release...

concerning clinical therapies relating to cancer. In particular, her work on Netrin-1, the antibody developed by her team, is an antitumor product that has been...

Chen ZF, Song HJ, Mei L, Xiong WC (Nov 2004). "Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci. 7 (11): 1204–12. doi:10.1038/nn1330. PMID 15494733...

Neuroscience. 92 (1): 83–95. doi:10.1016/S0306-4522(98)00751-9. PMID 10392832. S2CID 10924179. Birey F, Aguirre A (April 2015). "Age-Dependent Netrin-1 Signaling...