ORF1ab (also ORF1a/b) refers collectively to two open reading frames (ORFs), ORF1a and ORF1b, that are conserved in the genomes of nidoviruses, a group...

non-structural protein in the Coronavirus genome. Its gene is part of the ORF1ab reading frame and it is part of the pp1ab polyprotein; it is cleaved by...

The genome organization for a coronavirus is 5′-leader-UTR-replicase (ORF1ab)-spike (S)-envelope (E)-membrane (M)-nucleocapsid (N)-3′UTR-poly (A) tail...

O-acetyl-esterase activity and the active site FGDS, is present downstream to ORF1ab and upstream to S gene (Figure 1). Vijgen, Leen; Keyaerts, Els; Moës, Elien;...

by "ORF1ab+N" or "ORF1ab+N+S"). However, further uncertainty exists given that not all "New UK variant compatible" SGTF cases (positive on ORF1ab and...

20C/S:452R, is defined by five distinct mutations (I4205V and D1183Y in the ORF1ab gene, and S13I, W152C, L452R in the spike protein's S-gene), of which the...

papain-like proteinase (PLpro) instead of two in the open reading frame ORF1ab. SARSr-CoV was determined to be an early split-off from the betacoronaviruses...

the polyprotein include gag (group-specific antigen) in retroviruses and ORF1ab in Nidovirales. The latter name refers to the fact that a slippery sequence...

overall structure of β-CoV genome is similar to that of other CoVs, with an ORF1ab replicase polyprotein (rep, pp1ab) preceding other elements. This polyprotein...

were identified with distinct strains of coronavirus. An interaction with orf1ab polyprotein of the human coronavirus strain HKU1(HCov-HKU1) was shown in...

transcription and replication of viral RNAs. An alternative name is the ORF1ab polyprotein. It contains the polyprotein cleavage proteinases. The optimum...

spike (S) gene was the second most frequently mutated in the genome, after ORF1ab (which encodes most of the virus' nonstructural proteins). The evolution...

O-acetyl-esterase activity and the active site FGDS, is present downstream to ORF1ab and upstream to S gene (Figure 1). Lau, S. K. P.; Woo, P. C. Y.; Yip, C...

products ORF1a and ORF1ab In the equine arterivirus (EAV), the replicase gene is translated into open reading frame 1a (ORF1a) and ORF1ab [polyprotein]s....

in S-gene, A119S in N-gene, 5’UTR C100U, plus L3468V and synC11824U in ORF1ab-gene. Other mutations commonly found in P.2 are: 3’UTR C29754U, F120F (synC28253U)...

VSPs: viral envelope Spike Envelope Membrane Nucleocapsid VNPs: ORF1ab 3C-like protease (NS5) ORF3a ORF3b ORF3c ORF3d ORF6 ORF7a ORF7b ORF8 ORF9b...

CDC. The variant has five defining mutations (I4205V and D1183Y in the ORF1ab gene, and S13I, W152C, L452R in the spike protein's S-gene), of which the...

O-acetyl-esterase activity and the active site FGDS, is present downstream to ORF1ab and upstream to S gene (Figure 1). Woo, Patrick C. Y.; Huang, Yi; Lau, Susanna...

optional peptides. Certain T cell epitope peptides were also changed. "Orf1ab 5528T" replaced "Orf1 1636T" in the list of core peptides, because the former...

long. The genome is dominated by two large open reading frames, ORF1a and ORF1ab; these code for two polyproteins, PP1a and PP1ab. These polyproteins are...

VSPs: viral envelope Spike Envelope Membrane Nucleocapsid VNPs: ORF1ab 3C-like protease (NS5) ORF3a ORF3b ORF3c ORF3d ORF6 ORF7a ORF7b ORF8 ORF9b...

major open reading frames (ORFs). Two overlapping ORFs, together known as ORF1ab, are at the 5'-end, encoding the major non-structural proteins and are expressed...

O-acetyl-esterase activity and the active site FGDS, is present downstream to ORF1ab and upstream to S gene (Figure 1). Woo, Patrick C. Y.; Wang, Ming; Lau,...

PLPro domains are expressed as part of the large polyprotein encoded by the ORF1ab gene. PLPro domains are responsible for proteolytic processing of the polyprotein...

O-acetyl-esterase activity and the active site FGDS, is present downstream to ORF1ab and upstream to S gene (Figure 1). "Virus Taxonomy: 2018 Release". International...

compared to other SARSr-CoV (by nucleotide %) Strain Full-length genome ORF1ab S RBM ORF3a E M ORF6 ORF7a ORF7b ORF8 N ORF10 RaTG13 96.10% 96.50% 92.30%...

protein 2, NSP2 is one of the many non-structural proteins encoded in the orf1ab polyprotein. NSP2 alters the host cell environment rather than contribute...