• of viruses including adenovirus, reovirus, measles, herpes simplex, Newcastle disease virus, and vaccinia have been clinically tested as oncolytic agents...
    71 KB (8,503 words) - 07:52, 18 September 2024
  • Thumbnail for Oncolytic herpes virus
    Virotherapy Oncolytic virus Oncolytic adenovirus Herpes simplex virus Varghese S, Rabkin SD (December 2002). "Oncolytic herpes simplex virus vectors for cancer...
    16 KB (1,837 words) - 14:01, 20 December 2023
  • Thumbnail for Herpes simplex virus
    Herpes simplex virus 1 (cold sores) and 2 (genital herpes) (HSV-1 and HSV-2), also known by their taxonomic names Human alphaherpesvirus 1 and Human alphaherpesvirus...
    68 KB (7,356 words) - 01:20, 2 November 2024
  • Thumbnail for Talimogene laherparepvec
    Talimogene laherparepvec (category Oncolytic virus)
    Talimogene laherparepvec is a genetically engineered herpes virus (an oncolytic herpes virus). Two genes were removed – one that shuts down an individual...
    20 KB (1,871 words) - 23:06, 26 August 2024
  • vector for gene therapy and also as an oncolytic virus. Of the many different viruses being explored for oncolytic potential, an adenovirus was the first...
    38 KB (4,201 words) - 16:37, 17 August 2024
  • Thumbnail for Virus
    the virus gained approval for the treatment of melanoma in late 2015. Viruses that have been reprogrammed to kill cancer cells are called oncolytic viruses...
    155 KB (18,247 words) - 21:39, 28 October 2024
  • genital herpes respectively, but other members in the herpes family include chickenpox (varicella/zoster), cytomegalovirus, and Epstein-Barr virus. There...
    87 KB (8,781 words) - 15:27, 20 August 2024
  • Teserpaturev (category Oncolytic virus)
    Teserpaturev is an oncolytic virus for treatment of malignant glioma. Also known as G47∆, teserpaturev is a genetically engineered herpes simplex virus type 1. Originally...
    3 KB (267 words) - 17:33, 5 December 2023
  • Adeno-associated virus (AAV) has been researched as a viral vector in gene therapy for cancer treatment as an oncolytic virus. Currently there are not...
    10 KB (1,340 words) - 16:01, 18 July 2024
  • Thumbnail for Genetically modified virus
    using viruses. Viruses that have been used for gene therapy are, adenovirus, lentivirus, retrovirus and the herpes simplex virus. The most common virus used...
    34 KB (3,844 words) - 20:37, 24 September 2024
  • Thumbnail for Coxsackievirus
    wild-type Coxsackievirus A21, is being used in human clinical trials as an oncolytic virus. SCAR-Fc (Soluble Receptor Analogue) is an experimental prophylactic...
    14 KB (1,394 words) - 17:47, 17 March 2024
  • Infected cell protein 34.5 (category Virus stubs)
    protein Agarwalla PK, Aghi MK (2012). "Oncolytic herpes simplex virus engineering and preparation". Oncolytic Viruses. Methods in Molecular Biology. Vol. 797...
    2 KB (272 words) - 11:14, 13 January 2024
  • Thumbnail for Virulent Newcastle disease
    successful, complete inactivation of the virus in a space using a nonthermal plasma generator. Though the oncolytic effect of NDV was already documented in...
    16 KB (1,673 words) - 17:07, 20 October 2024
  • Thumbnail for Granulocyte-macrophage colony-stimulating factor
    in December 2015 by the EMA, as an oncolytic virotherapy, commercialized by Amgen Inc. This oncolytic herpes virus, named Talimogene laherparepvec, has...
    17 KB (1,672 words) - 11:59, 30 August 2023
  • Thumbnail for Viral vector
    Viral vector (redirect from Virus construct)
    The next generation of herpes simplex virus-based oncolytic immunotherapies for cancer treatment". Molecular Therapy Oncolytics. 31: 100729. doi:10.1016/j...
    48 KB (5,532 words) - 12:43, 9 October 2024
  • convert viruses into therapeutic agents by reprogramming viruses to treat diseases. There are three main branches of virotherapy: anti-cancer oncolytic viruses...
    30 KB (3,501 words) - 10:41, 23 July 2024
  • Thumbnail for Murine respirovirus
    2003). "Effective therapy of metastatic ovarian cancer with an oncolytic herpes simplex virus incorporating two membrane fusion mechanisms". Clinical Cancer...
    296 KB (31,942 words) - 21:22, 28 August 2024
  • virus in "the wild". Viruses may also be attenuated via reverse genetics. Attenuation by genetics is also used in the production of oncolytic viruses...
    40 KB (4,224 words) - 05:08, 15 August 2024
  • Thumbnail for Adeno-associated virus
    that, despite being present in people infected by helper viruses such as adenovirus or herpes virus, AAV itself did not cause any disease. Wild-type AAV has...
    72 KB (8,401 words) - 06:44, 28 August 2024
  • Thumbnail for Measles
    Measles (category Virus-related cutaneous conditions)
    Bexon A, Cattaneo R, Dingli D, Dispenzieri A, et al. (September 2019). "Oncolytic Measles Virotherapy and Opposition to Measles Vaccination". Mayo Clinic...
    134 KB (12,240 words) - 16:26, 8 October 2024
  • Campadelli-Fiume is a virologist with a primary research focus on herpes simplex virus, fusion and viral entry. She is a retired professor of virology from...
    17 KB (1,624 words) - 19:34, 16 February 2023
  • Thumbnail for Cancer immunotherapy
    of viruses including adenovirus, reovirus, measles, herpes simplex, Newcastle disease virus and vaccinia have now been clinically tested as oncolytic agents...
    92 KB (12,517 words) - 05:38, 1 October 2024
  • PMID 30996096. "Design and Analysis of Shedding Studies for Virus or Bacteria-Based Gene Therapy and Oncolytic Products; Guidance for Industry | FDA". www.fda.gov...
    14 KB (1,408 words) - 16:27, 18 February 2024
  • Thumbnail for Protein phosphatase 1
    PMID 24936058. Agarwalla PK, Aghi MK (2012). "Oncolytic herpes simplex virus engineering and preparation". Oncolytic Viruses. Methods in Molecular Biology. Vol. 797...
    18 KB (2,050 words) - 17:09, 2 October 2024
  • Thumbnail for Genetically modified organism
    virus shown to target tumors alone Reuters Science, Retrieved 5 September 2012 Garber K (March 2006). "China approves world's first oncolytic virus therapy...
    223 KB (24,619 words) - 13:41, 4 November 2024
  • treatment of solid tumors and hematological malignancies. Pelareorep is an oncolytic virus, which means that it preferentially lyses cancer cells. Pelareorep...
    16 KB (1,750 words) - 18:48, 22 September 2024
  • Thumbnail for Ras GTPase
    Ras GTPase (redirect from Rat sarcoma virus)
    2006). "A mutant type 2 herpes simplex virus deleted for the protein kinase domain of the ICP10 gene is a potent oncolytic virus". Molecular Therapy. 13...
    34 KB (4,040 words) - 14:34, 19 July 2024
  • Thumbnail for Glioblastoma
    Suryawanshi YR, Schulze AJ (July 2021). "Oncolytic Viruses for Malignant Glioma: On the Verge of Success?". Viruses. 13 (7): 1294. doi:10.3390/v13071294....
    78 KB (8,704 words) - 07:39, 8 October 2024
  • Thumbnail for Melanoma
    vasculature. Talimogene laherparepvec (T-VEC) (which is a herpes simplex virus type 1–derived oncolytic immunotherapy), was shown to be useful against metastatic...
    154 KB (16,086 words) - 11:16, 2 November 2024
  • the patient using oncolytic viruses. This approach was used in the drug talimogene laherparepvec, a variant of herpes simplex virus engineered to selectively...
    28 KB (3,212 words) - 04:50, 2 November 2024