Orphan genes, ORFans, or taxonomically restricted genes (TRGs) are genes that lack a detectable homologue outside of a given species or lineage. Most genes...

including so-called orphan genes, defined as genes that lack any identifiable homolog. It is important to note, however, that not all orphan genes arise de novo...

called pseudogenes.: 7.6  "Orphan" genes, whose sequence shows no similarity to existing genes, are less common than gene duplicates. The human genome...

An orphan drug is a pharmaceutical agent that is developed to treat certain rare medical conditions. An orphan drug would not be profitable to produce...

Orphan Black – 7 Genes (Japanese: (オーファン・ブラック～七つの遺伝子～ known internationally as Orphan Black Japan), launched December 2, 2017, on Fuji Television, is...

RAR-related orphan receptor gamma (RORγ) is a protein that in humans is encoded by the RORC (RAR-related orphan receptor C) gene. RORγ is a member of the...

Orphan Black is a Canadian science-fiction thriller television series created by screenwriter Graeme Manson and director John Fawcett and starring Tatiana...

subfunctionalize following gene duplication, contributing to the prevalence of orphan genes. Which member of an overlapping gene pair is younger can be identified...

identify orphan genes, since if the gene shows up in an organism outside of the ancestral lineage, then it wouldn't be classified as an orphan gene. Although...

Orphan Black is a Canadian science fiction television series that premiered on March 30, 2013, in Canada on Space. The series was created by Graeme Manson...

GPCR orphan receptors are usually given the name "GPR" followed by a number, for example GPR1. In the GPCR family, nearly 100 receptor-like genes remain...

was isolated in 2016. The core features such as the order of ORFs and orphan genes (ORFans) are well conserved between the two known species. The rate of...

RAR-related orphan receptor alpha (RORα), also known as NR1F1 (nuclear receptor subfamily 1, group F, member 1) is a nuclear receptor that in humans is...

Orphan-Maker (Peter) is a fictional mutant character appearing in American comic books published by Marvel Comics. His first appearance was in X-Factor...

receptors work with other proteins to regulate the expression of specific genes, thereby controlling the development, homeostasis, and metabolism of the...

isolated from the gene family they originated in, are referred to as orphans. Gene families arose from multiple duplications of an ancestral gene, followed by...

orphan hormone nuclear receptors". Genes & Development. 8 (5): 538–553. doi:10.1101/gad.8.5.538. PMID 7926749. "Entrez Gene: RORB RAR-related orphan receptor...

focused on gene therapies. He previously served as the Director of the Gene Therapy Program, Rose H. Weiss Professor and Director of the Orphan Disease Center...

Nuclear receptor 4A1 has the systematic HUGO gene symbol NR4A1. It belongs to a group of three closely related orphan receptors, the NR4A family (NR4A). The...

rare diseases where prior estimates had been ~7,000 in the Orphan Drug Act. Global Genes has also estimated that currently approximately 10,000 rare...

691 protein-coding genes and 39 RNA genes. The species also possesses a large number of orphan genes, possibly through viral gene transfer. Methanopyrus...

member 3) also known as neuron-derived orphan receptor 1 (NOR1) is a protein that in humans is encoded by the NR4A3 gene. NR4A3 is a member of the nuclear...

caused by either a recessive or dominant gene. In many cases people are not aware that they carry a relevant gene until they have children who begin to show...

An orphan device is a product or an equipment intended for the prevention, prediction, diagnosis, support, treatment or management of a life-threatening...

CD (May 2003). "Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription". Circulation Research. 92 (9):...

fictional characters in literature and comics. While the exact definition of orphan and foundlings varies, one legal definition is a child bereft through "death...

aphid-specific orphan genes making up 20% of the genome and gene duplication present in more than 2000 gene families. These orphan genes and gene duplications...

their genes with other NCLDVs; however, ~46% are homologous to bacterial genes and the remainder are orphan genes (ORFans). Specifically, the gene encoding...

Gene Rodman Wolfe (May 7, 1931 – April 14, 2019) was an American science fiction and fantasy writer. He was noted for his dense, allusive prose as well...

Elivaldogene autotemcel, sold under the brand name Skysona, is a gene therapy used to treat cerebral adrenoleukodystrophy (CALD). It was developed by Bluebird...