attach a chain of ubiquitin molecules to p53, thereby flagging p53 for proteosomal degradation. Normally, p53 acts to prevent cell growth and promotes...

This factor combined with two different immunohistochemical expression of p53, Her2 and p16 leads to two different genetic pathways that likely progress...

cycle regulated. PMS2 has also been shown to interact with p53 and p73. In the absence of p53, PMS2-deficient and PMS2-proficient cells are still capable...

causes cell growth. The p53 pathway can either be suppressed or highly activated in endometrial cancer. When a mutant version of p53 is overexpressed, the...

redirecting the complex to bind p53, a well-known tumor suppressor gene whose inactivation is found in many types of cancer. Thus, p53 undergoes ubiquitylation...

while in grades 2 and 3, damage to three further genes – CDKN2A (p16), p53, and SMAD4 – are increasingly often found. A second type is the intraductal...

Danny Superman on the Couch (2004). Continuum International Publishing Group p53. ISBN 0-8264-1539-3 Engle, Gary "What Makes Superman So Darned American?"...

viral spread by increasing p53 activity, which kills virus-infected cells by promoting apoptosis. The effect of IFN on p53 is also linked to its protective...

therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists". Annals of the New...

2014. Salve V. Asis (December 27, 2014). "Tinalo si Kris, Praybeyt… naka-P53 M sa unang araw ng MMFF!". Pilipino Star Ngayon. Retrieved August 12, 2015...

formation is solar radiation, through a variety of mechanisms. Mutation of the p53 tumor suppressor gene, induced by UV radiation, has been identified as a...

in. Retrieved 20 October 2020. "Contract Signing with M/s SECON, Visakhapatnam for Acquisition of Eight Missile cum Ammunition Barge for Indian Navy"....

anticancer properties through its interaction with tumor-suppressor protein p53. In its oxidized form, azurin (Cu2+Az) receives an electron from its redox...

suppressor genes can also increase one's risk of developing breast cancer, namely p53 (causes Li–Fraumeni syndrome), PTEN (causes Cowden syndrome), and PALB1....

an up-regulation of mdm2 protein, which decreases p53 protein levels. Thus, taking into account p53's function, a lack of it could cause a faster accumulation...

suppressors is known as p53. It plays such a critical role in regulation of cell division and cell death that in 70% of cancer cells p53 is found either mutated...

is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair". Proceedings of the National...

root causes of p53-related cancers. In 2004, Folding@home was used to perform the first molecular dynamics study of the refolding of p53's protein dimer...

promote normal PCD. P53 functions as a tumor suppressor that is involved in preventing cancer and occurs naturally in apoptotic pathways. P53 causes cells to...

p53 target genes. The importance of CHD8 can be observed in studies where CHD8-knockout mice died after 5.5 embryonic days because of widespread p53-induced...

and the skin cancers. Examination of mutations in the p53 gene in tumors from XP patients reveal p53 mutations characteristic of UV exposure in the majority...

Percy pass through a station ("Percy runs away" in Troublesome Engines (p53)). This was Christopher Awdry's only appearance in an illustration, but he...

Maj. Rafiqul, A Tale of Millions, p147 Hasan, Moyeedul, Muldhara 1971, p53, note 67, ISBN 984-05-0121-6 Hasan, Moyeedul, Muldhara 1971, p11-14 Jacob...

Brookes, Chris Davey p21 Avro Vulcan, Part 1 RAF Illustrated By Kev Darling p53–54 "World News." Flight, 17 January 1963, p. 88. Wynn 1997, p. 313. Quoting...

alternative reading frame mutation in this gene leads to the destabilization of p53, a transcription factor involved in apoptosis and in 50% of human cancers...

pathway, other mutations must occur for the cell to become cancerous. The p53 protein, produced by the TP53 gene, normally monitors cell division and induces...

instead often have mutations that have inactivated the tumor suppressors p53 and RB. A cluster of tumor suppressor genes on the short arm of chromosome...

for generations of economics students. Called his magnum opus, it ran to eight editions by 1920. A ninth (variorum) edition was published in 1961, edited...

(Murray 1998, p53) "The death of Floyd is a minor milestone on the road from puzzle gaming to an expressive narrative art." (Murray 1998, p53) Koster, Raph...

6/5-shot revolver rifle;.44/.56) Greene rifle (Bolt-action breech-loader) P53 Enfield (.577) P51 Enfield Musketoon ("Artillery Carbine"; 24" barrel, .69)...