Parkin is a 465-amino acid residue E3 ubiquitin ligase, a protein that in humans and mice is encoded by the PARK2 gene. Parkin plays a critical role in...

Parkin may refer to: Parkin (cake), a type of cake Parkin (protein), a ligase Parkin (surname), people with the surname Parkin Parkin, a brand name of...

stress-induced mitochondrial dysfunction. PINK1 activity causes the parkin protein to bind to depolarized mitochondria to induce autophagy of those mitochondria...

its regulator BNIP3 in mammals. Mitophagy is regulated by PINK1 and parkin proteins. In addition to the selective removal of damaged mitochondria, mitophagy...

populations. Encoded by the PARK2 gene, the PARKIN protein is a ubiquitin ligase that is indicated in protein processing as well as degradation and is essential...

is Parkinson's disease. It is caused by a mutation in the parkin gene. Parkin is a protein that functions in complex with CHIP as a ubiquitin ligase and...

Zinc finger protein 746 also known as Parkin-interacting substrate (PARIS) is a zinc finger protein that, in humans, is encoded by the ZNF746 gene and...

its regulator BNIP3 in mammals. Mitophagy is regulated by PINK1 and parkin proteins. The occurrence of mitophagy is not limited to the damaged mitochondria...

ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin, recognizes a protein substrate, and assists...

used as feedstock for bioproducts like plastic and protein-rich food for fish and livestock. Parkin continues research in the area of camelina and collaborated...

been shown to interact with Dopamine transporter, Parkin (ligase), Phospholipase D1, SNCAIP, Tau protein. Beta amyloid Synuclein Contursi Terme - the village...

Parkin coregulated gene protein is a protein that in humans is encoded by the PACRG gene. This gene encodes a protein that is conserved across metazoans...

the PINK1 and Parkin complex, having this been shown to drive autophagy of mitochondria (also known as mitophagy). PINK1 is a protein normally transported...

and function of many biological molecules, including vitamins, drugs, proteins and nucleic acids such as DNA. X-ray crystallography is still the primary...

p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration". Human Molecular Genetics...

phosphorylated tyrosine residues on proteins: [a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate Protein tyrosine (pTyr) phosphorylation...

organising protein (Hop) is encoded in the human by the STIP1 gene. It functions as a co-chaperone which reversibly links together the protein chaperones...

AMBRA1 (activating molecule in Beclin1-regulated autophagy) is a protein that is able to regulate cancer cells through autophagy. AMBRA1 is described...

Interferons (IFNs, /ˌɪntərˈfɪərɒn/ IN-tər-FEER-on) are a group of signaling proteins made and released by host cells in response to the presence of several...

capacity of PINK1 and parkin to trigger post-translational modifications in their substrates, have yet to be evaluated. The MFN2 protein may play a role in...

respectively Genes such as PARK2, PARK6, PARK7 and PARK9 which code for parkin (PRKN), PTEN-induced putative kinase 1 (PINK1), DJ-1 and ATP13A2 respectively...

ubiquitination, and mitochondrial clearance by affecting Parkin/PRKN recruitment. ATXN3 MDM2 OPTN Parkin RAB10 RNF34 STUB1 VCP FYVE domain RING finger domain...

indicating an affective mechanism between these factors. Parkin, an E3 ubiquitin ligase involved in protein degradation, is commonly seen in autosomal recessive...

membrane. LRRK2 interacts with the C-terminal R2 RING finger domain of parkin, and parkin interacted with the COR domain of LRRK2. Expression of mutant LRRK2...

recently, UCH-L1 has been demonstrated to interact with the E3 ligase, parkin. Parkin has been demonstrated to bind and ubiquitinylate UCH-L1 to promote lysosomal...

sites. Mutations in the genes that encode the proteins Parkin, PINK1, alpha-Synuclein (α-Syn) or the protein deglycase DJ-1 have been linked to this disease...

stabilizing protein-protein interactions in biological systems. These molecules act as "glue" by enhancing the affinity between proteins, ultimately influencing...

involved in PD. In neurons, Miro interacts with two key proteins involved in PD, PINK1 and Parkin. Following depolarization of the mitochondria, PINK1 phosphorylates...

Optineurin is a protein that in humans is encoded by the OPTN gene. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play...

investigations of cell cycle control mechanisms such as the retinoblastoma protein. The World Health Organization's International Agency for Research on Cancer...