Pembrolizumab, sold under the brand name Keytruda, is a humanized antibody, more specifically a PD-1 Inhibitor, used in cancer immunotherapy that treats...
80 KB (7,412 words) - 02:30, 16 October 2024
As adjuvant therapy, mRNA-4157 monotherapy and in combination with pembrolizumab have been investigated in patients with resected solid tumors (melanoma...
9 KB (899 words) - 20:37, 28 April 2024
system. Atezolizumab is an anti PD-L1 monoclonal antibody. Nivolumab and Pembrolizumab are anti PD-1 monoclonal antibodies. Ipilimumab is a monoclonal antibody...
51 KB (5,333 words) - 22:13, 7 September 2024
Favezelimab/pembrolizumab is a fixed-dose combination of two monoclonal antibodies developed by Merck to treat various cancers. Timmerman, John; Lavie...
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treatment options. Pembrolizumab monotherapy is an appealing approach for these patients, with median OS of 30 months with pembrolizumab single agent compared...
60 KB (6,590 words) - 06:01, 15 September 2024
immunotherapy drugs blocking LAG3, B7-H3, KIR, OX40, PARP, CD27, and ICOS. Pembrolizumab (Keytruda, formerly MK-3475 and lambrolizumab) was developed by Merck...
35 KB (3,450 words) - 03:38, 30 September 2024
Cancer immunotherapy (section Pembrolizumab)
checkpoint inhibitors include antibodies such as ipilimumab, nivolumab, and pembrolizumab. Dendritic cell therapy provokes anti-tumor responses by causing dendritic...
92 KB (12,517 words) - 05:38, 1 October 2024
undergoing treatment every three weeks with pembrolizumab. In 2023, he announced that the pembrolizumab was waning in effectiveness and chemotherapy...
20 KB (2,079 words) - 19:00, 15 October 2024
It is being tested by itself and in a fixed-dose combination with pembrolizumab. Garralda, E.; Sukari, A.; Lakhani, N. J.; Patnaik, A.; Lou, Y.; Im...
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advanced NSCLC but with high PD-L1 levels, who will be treated with pembrolizumab in combination with CIMAvax instead of nivolumab. As of 2023, accural...
16 KB (1,556 words) - 23:09, 17 July 2024
drugs or products, each with over $1 billion in revenue: Keytruda (pembrolizumab), a humanized antibody used in cancer immunotherapy that had $14.3 billion...
98 KB (9,657 words) - 08:07, 15 October 2024
liver, and that he had begun treatment with the immunotherapy drug pembrolizumab and was about to start radiation therapy. His healthcare was managed...
337 KB (30,109 words) - 21:18, 20 October 2024
chemoresistant MSI-high tumors can be treated with dostarlimab and pembrolizumab. In the European Union, dostarlimab is indicated as monotherapy for...
37 KB (3,213 words) - 00:29, 30 September 2024
Immunotherapy: mechanism of action for Durvalumab, Pembrolizumab, Ipilimumab, Atezolizumab....
28 KB (2,721 words) - 04:14, 1 October 2024
quality-assured biosimilars Afatinib and gefitinib are alternatives Pembrolizumab is an alternative, including quality-assured biosimilars Enzalutamide...
67 KB (4,835 words) - 05:59, 17 August 2024
for those whose tumors express PD-L1. And the similar immunotherapy pembrolizumab for those whose tumors have mutations in various DNA repair pathways...
135 KB (15,182 words) - 15:11, 20 October 2024
PD-L1, but are sometimes effective in those that do not. Treatment with pembrolizumab, atezolizumab, or combination nivolumab plus ipilimumab are all superior...
90 KB (9,784 words) - 07:53, 10 October 2024
inhibitors have been approved for NSCLC, including anti-PD-1 nivolumab and pembrolizumab. Anti-PD-1 agents are used for patients with advanced NSCLC whose tumors...
42 KB (4,603 words) - 02:26, 2 September 2024
response rate with median progression free survival of 10.5 months Pembrolizumab: 12% objective response rate with median progression free survival of...
21 KB (2,187 words) - 14:39, 28 May 2024
clinical and observational studies, immune checkpoint inhibitors (e.g., pembrolizumab) have been tested in mucosal melanomas and have shown promising response...
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repair benefit from treatment with the immune checkpoint inhibitor drug pembrolizumab and PARP inhibitors, namely olaparib, rucaparib, or niraparib. Bone...
77 KB (8,910 words) - 03:34, 16 October 2024
2014 and by the US FDA in December 2014 to treat metastatic melanoma. Pembrolizumab (Keytruda, MK-3475, Merck), which also targets PD-1 receptors, was approved...
39 KB (5,010 words) - 05:27, 17 August 2024
system. Atezolizumab is an anti PD-L1 monoclonal antibody. Nivolumab and pembrolizumab are anti PD-1 monoclonal antibodies. Ipilimumab is a monoclonal antibody...
43 KB (4,183 words) - 04:17, 1 October 2024
(e.g. sunitinib), checkpoint inhibitors (e.g. ipilimumab, nivolumab, pembrolizumab, atezolizumab) Contrast agent Gadolininum based contrast agent Other...
20 KB (2,303 words) - 18:34, 27 July 2024
licensed monoclonal antibodies include: Pembrolizumab (Keytruda) binds to PD-1 proteins found on T cells. Pembrolizumab blocks PD-1 and help the immune system...
20 KB (2,234 words) - 01:21, 22 July 2024
Retrieved 21 August 2020. "Keytruda- pembrolizumab injection, powder, lyophilized, for solution Keytruda- pembrolizumab injection, solution". DailyMed. 17...
137 KB (4,083 words) - 21:25, 19 October 2024
cytotoxic component MMAE, and the checkpoint inhibitors, Nivolumab and Pembrolizumab. This has been an important step in the treatment for the few, but still...
87 KB (8,525 words) - 06:47, 19 October 2024
inhibitors PD-1 inhibitorsTooltip Programmed cell death protein 1 Nivolumab Pembrolizumab Cemiplimab Dostarlimab Retifanlimab Toripalimab PD-L1 inhibitorsTooltip...
46 KB (4,813 words) - 05:06, 15 October 2024
Pemetrexed is also recommended in combination with carboplatin and pembrolizumab for the first-line treatment of advanced non-small cell lung cancer...
16 KB (1,212 words) - 15:30, 26 September 2024
inhibitors PD-1 inhibitorsTooltip Programmed cell death protein 1 Nivolumab Pembrolizumab Cemiplimab Dostarlimab Retifanlimab Toripalimab PD-L1 inhibitorsTooltip...
9 KB (603 words) - 00:28, 30 September 2024