Phosphoinositide 3-kinase inhibitors (PI3K inhibitors) are a class of medical drugs that are mainly used to treat advanced cancers. They function by inhibiting...
44 KB (5,305 words) - 21:36, 24 March 2024
Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth...
32 KB (3,463 words) - 17:34, 20 November 2023
Wortmannin (category Phosphoinositide 3-kinase inhibitors)
inhibitor of phosphoinositide 3-kinases (PI3Ks). It has an in vitro inhibitory concentration (IC50) of around 5 nM, making it a more potent inhibitor...
12 KB (1,138 words) - 05:28, 7 May 2024
Phosphoinositide 3-kinase#Class I Phosphoinositide 3-kinase inhibitor Stein RC (September 2001). "Prospects for phosphoinositide 3-kinase inhibition as a cancer...
3 KB (281 words) - 17:41, 25 April 2024
Idelalisib (category Phosphoinositide 3-kinase inhibitors)
acts as a phosphoinositide 3-kinase inhibitor; more specifically, it blocks P110δ, the delta isoform of the enzyme phosphoinositide 3-kinase. It was developed...
16 KB (1,254 words) - 06:35, 1 July 2024
the field of biochemistry, PDPK1 refers to the protein 3-phosphoinositide-dependent protein kinase-1, an enzyme which is encoded by the PDPK1 gene in humans...
18 KB (2,127 words) - 19:11, 8 April 2024
for the activity of the enzyme, and 3-phosphoinositide-dependent protein kinase-1 (PDPK1) is the upstream kinase responsible for initiating the process...
27 KB (2,650 words) - 21:16, 19 March 2024
Eganelisib (category Phosphoinositide 3-kinase inhibitors)
treatment for cancer. It is a highly selective phosphoinositide 3-kinase inhibitor, and thus works by inhibiting the enzyme PIK3CG, disrupting the PI3K/AKT/mTOR...
9 KB (775 words) - 22:48, 8 July 2024
Leniolisib (category Phosphoinositide 3-kinase inhibitors)
selective phosphoinositide 3-kinase inhibitor (PI3Kδ inhibitor), which means it blocks a form of the protein called phosphoinositide 3-kinase delta (PI3Kδ)...
9 KB (583 words) - 17:26, 7 February 2024
for the treatment of B-cell malignancies. It is a PI3Kδ (phosphoinositide 3-kinase) inhibitor. Gerds AT, Bartalucci N, Assad A, Yacoub A (August 2022)...
3 KB (69 words) - 05:46, 5 July 2024
colon carcinoma cell growth by Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002. OncoTargets and therapy. 2015;8:877...
27 KB (3,864 words) - 01:11, 4 December 2023
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform also known as phosphoinositide 3-kinase (PI3K) delta isoform or p110δ is an...
23 KB (2,500 words) - 17:09, 28 June 2024
LY294002 (category Phosphoinositide 3-kinase inhibitors)
chemical compound that is a potent inhibitor of numerous proteins, and a strong inhibitor of phosphoinositide 3-kinases (PI3Ks). It is generally considered...
6 KB (442 words) - 06:19, 2 April 2024
Taselisib (category Phosphoinositide 3-kinase inhibitors)
that was in development by Roche. It is a small molecule phosphoinositide 3-kinase inhibitor targeting the PI3K isoform p110α (PIK3CA). Roche announced...
4 KB (178 words) - 12:04, 29 May 2023
Inavolisib (category Phosphoinositide 3-kinase inhibitors)
GDC-0077, is an investigational, highly selective inhibitor and degrader of mutant phosphatidylinositol 3-kinase (PI3K) alpha. The PI3K-mediated signalling pathway...
21 KB (2,184 words) - 23:36, 14 May 2024
the di-phosphorylated phosphoinositide PIP2 is only phosphorylated by the family of enzymes, PI 3-kinases (phosphoinositide 3-kinase or PI3-K), and only...
35 KB (3,831 words) - 03:01, 8 July 2024
P110α (category Genes on human chromosome 3)
received at least two prior systemic therapies. Phosphoinositide 3-kinase Phosphoinositide 3-kinase inhibitor PIK3CA-related overgrowth spectrum P110α has...
17 KB (1,929 words) - 02:08, 3 December 2023
Duvelisib (category Phosphoinositide 3-kinase inhibitors)
duvelisib may have a higher risk of death. Duvelisib is a Phosphoinositide 3-kinase inhibitor, specifically of the delta and gamma isoforms of PI3K. This...
19 KB (1,347 words) - 13:47, 26 June 2024
Buparlisib (category Phosphoinositide 3-kinase inhibitors)
It is a small molecule orally-available pan-class I phosphoinositide 3-kinase (PI3K) inhibitor. Buparlisib was under investigation as a treatment for...
8 KB (690 words) - 07:37, 12 November 2023
phosphatidylinositol 3-phosphate (PI3P). The kinases include phosphoinositide 3-kinase (PI3K), phosphatidylinositol-4-phosphate 3-kinase, and phosphatidylinositol-4...
33 KB (3,805 words) - 11:22, 1 April 2024
Alpelisib (category Phosphoinositide 3-kinase inhibitors)
information". Union Register of medicinal products. Retrieved 3 March 2023. "FDA approves first PI3K inhibitor for breast cancer". U.S. Food and Drug Administration...
15 KB (967 words) - 10:52, 14 May 2024
gene. It is a serine/threonine kinase that acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway. As the name suggests...
17 KB (2,127 words) - 02:01, 8 April 2024
phosphoinositide 3-kinase inhibitors produced overall response rates of ~40% and complete response rates of 1–20%; Bruton's tyrosine kinase inhibitor...
67 KB (7,967 words) - 19:22, 29 April 2024
PI3K/AKT/mTOR pathway (section PI3K inhibitor)
loss-of-function mutations or epigenetic silencing of PTEN. The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway...
36 KB (4,322 words) - 16:42, 6 October 2023
disease-causing mutations. Approved drugs that inhibit BTK: Ibrutinib (Imbruvica), a selective Bruton's tyrosine kinase inhibitor. Acalabrutinib (Calquence), approved...
22 KB (2,389 words) - 06:43, 22 April 2024
dehydrogenase phosphatase. (Pyruvate dehydrogenase kinase should not be confused with Phosphoinositide-dependent kinase-1, which is also sometimes known as "PDK1"...
14 KB (1,711 words) - 16:27, 25 October 2023
PIKFYVE (redirect from FYVE finger-containing phosphoinositide kinase)
PIKfyve, a FYVE finger-containing phosphoinositide kinase, is an enzyme that in humans is encoded by the PIKFYVE gene. The principal enzymatic activity...
27 KB (2,930 words) - 20:14, 13 January 2024
different second messenger, presumably generated through a phosphoinositide 3-kinase (PI3-kinase) pathway. It is now known that PKMζ is not the result of...
21 KB (2,598 words) - 01:04, 22 December 2023
PTK2 (redirect from PTK2 protein tyrosine kinase 2)
migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C". Blood. 95 (8): 2505–13. doi:10.1182/blood.V95.8.2505...
41 KB (4,724 words) - 09:43, 11 December 2023
Class III PI 3-kinase is a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity...
4 KB (511 words) - 18:08, 19 June 2024