the 4-sulfamoylphenyl on the 1-pyrazol substituent is required for COX-2 inhibition and the 4-methyl on the 5-pyrazol system has low steric hindrance...
61 KB (6,086 words) - 21:24, 28 September 2024
Pyrazolylalanine synthase (redirect from L-serine hydro-lyase (adding pyrazole; 3-(pyrazol-1-yl)-L-alanine-forming))
reaction L-serine + pyrazole ⇌ {\displaystyle \rightleftharpoons } 3-(pyrazol-1-yl)-L-alanine + H2O This enzyme belongs to the family of lyases, specifically...
1 KB (119 words) - 15:37, 26 August 2023
International. ISBN 8122415652.: 226 "5-Methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one". Chemspider. Retrieved February 24, 2019. "Antipyrine drugs and...
6 KB (453 words) - 12:44, 14 July 2024
Mascitti, K.F. McClure, M.J. Munchhof, R.P. Robinson, Jr., "4-(5-Cyano-pyrazol-1-yl)-piperidine derivatives as GPR 119 modulators", issued 2012-5-31,...
15 KB (1,405 words) - 09:56, 22 June 2024
℞-only EU: Rx-only Identifiers IUPAC name 2-Hydroxy-6-{[2-(1-isopropyl-1H-pyrazol-5-yl)-3-pyridinyl]methoxy}benzaldehyde CAS Number 1446321-46-5 PubChem...
14 KB (1,046 words) - 03:42, 28 September 2024
1,9-Pyrazoloanthrone (redirect from Anthra(1,9-cd)pyrazol-6(2H)-one)
Elslager EF (1984). "5-[(Aminoalkyl)amino]-substituted anthra[1,9-cd]pyrazol-6(2H)-ones as novel anticancer agents. Synthesis and biological evaluation"...
4 KB (261 words) - 22:43, 25 April 2023
experimental mGluR5 positive modulators like 4-nitro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (VU-29). reducing anxiety by positively modulating GABA...
19 KB (2,293 words) - 20:29, 8 July 2024
Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone...
3 KB (238 words) - 20:24, 22 June 2024
(17α-Me-THG) ∆9,11-17α,18-DiMe-19-NT 230 143 <0.1 155 36 ? ? Stanozolol 2,3-Pyrazol-17α-Me-DHT ? ? ? ? ? 1–36 ? Testosterone T 1.0–1.2 100 <0.1 0.17 0.9 19–82...
209 KB (21,568 words) - 16:45, 2 October 2024
injection. Stanozolol, also known as 17α-methyl-2'H-androst-2-eno[3,2-c]pyrazol-17β-ol, is a synthetic 17α-alkylated androstane steroid and a derivative...
36 KB (3,328 words) - 23:42, 31 August 2024
In general: ℞ (Prescription only) Identifiers IUPAC name 5-methyl-2-phenyl-4H-pyrazol-3-one CAS Number 89-25-8 Y PubChem CID 4021 DrugBank DB12243 Y ChemSpider...
19 KB (1,620 words) - 03:50, 14 August 2024
(November 2014). "Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent...
10 KB (1,035 words) - 22:06, 27 March 2024
IV). Identifiers IUPAC name [(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino] methanesulfonic acid CAS Number 50567-35-6 Y 68-89-3...
53 KB (4,611 words) - 08:38, 14 September 2024
6S)-2-(2,5-Difluorophenyl)-5-(2-methylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-6-(trifluoromethyl)oxan-3-amine CAS Number 1844874-26-5 PubChem CID...
5 KB (273 words) - 04:09, 22 January 2024
Christian M.; Panak, Petra J.; Denecke, Melissa A. (2010). "6-(3,5-Dimethyl-1H-pyrazol-1-yl)-2,2′-bipyridine as Ligand for Actinide(III)/Lanthanide(III) Separation"...
67 KB (7,814 words) - 10:57, 6 October 2024
(2017). "Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation...
16 KB (1,167 words) - 20:00, 8 August 2024
use, including Gleevec (imatinib) and Iressa (gefitinib). Anthra(1,9-cd)pyrazol-6(2H)-one Staurosporine Drug developments for kinase inhibitors are started...
15 KB (1,635 words) - 23:25, 13 August 2024
Pigment Yellow 10, 4-[2',5'-(dichlorophenyl)hydrazono]-5-methyl-2-phenyl-3H-pyrazol-3-one". Acta Crystallographica C. C44 (10): 1767–70. Bibcode:1988AcCrC...
2 KB (132 words) - 16:18, 20 March 2024
5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro- 1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl]acetamide CAS Number 2189684-44-2 DrugBank DB15673 ChemSpider 81367881...
23 KB (1,596 words) - 06:51, 9 September 2024
Identifiers IUPAC name 4-[3-(cyanomethyl)-3-[4-(3,5-dimethyl-1H-pyrazol-4-yl)pyrazol-1-yl]azetidin-1-yl]-2,5-difluoro-N-[(2S)-1,1,1-trifluoropropan-2-yl]benzamide...
4 KB (235 words) - 03:07, 16 September 2024
Bunaftine FT-104 Hydroxystenozole, also known as 17α-methylandrost-4-eno[3,2-c]pyrazol-17β-ol This set index page lists chemical structure articles associated...
385 bytes (69 words) - 01:15, 1 October 2024
2597–2599. doi:10.1002/cber.188301602194. von Pechmann, Hans (1898). "Pyrazol aus Acetylen und Diazomethan". Berichte der deutschen chemischen Gesellschaft...
13 KB (1,070 words) - 18:13, 3 October 2024
identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia"...
6 KB (395 words) - 01:45, 22 August 2024
Identifiers IUPAC name (3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile CAS Number 941678-49-5 Y PubChem CID 25126798 IUPHAR/BPS...
26 KB (2,102 words) - 02:19, 16 July 2024
name [(3R)-4-[2-[2-[[3-(2-amino-6-chloropyrimidin-4-yl)-1-(difluoromethyl)pyrazol-4-yl]methyl]phenoxy]ethyl]morpholin-3-yl]methanol CAS Number 2857049-72-8...
3 KB (259 words) - 21:21, 25 May 2024
Clinical data ATC code None Identifiers IUPAC name 3-[3-(3,5-Dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluorobenzoic acid CAS Number 1446711-81-4 PubChem CID...
4 KB (160 words) - 08:23, 31 December 2023
N02BB04 (WHO) Identifiers IUPAC name 1,5-Dimethyl-2-phenyl-4-propan-2-yl-pyrazol-3-one CAS Number 479-92-5 Y PubChem CID 3778 ChemSpider 3646 Y UNII OED8FV75PY...
6 KB (374 words) - 14:01, 17 July 2024
[(2S)-1-{[4-(3-{5-chloro-2-fluoro-3-[(methylsulfonyl)amino]phenyl}-1-isopropyl-1H-pyrazol-4-yl)-2-pyrimidinyl]amino}-2-propanyl]carbamate CAS Number 1269440-17-6...
11 KB (735 words) - 03:41, 6 August 2024
℞ (Prescription only) Identifiers IUPAC name 2-{4-[(methylamino)carbonyl]- 1H-pyrazol-1-yl}adenosine CAS Number 313348-27-5 Y 875148-45-1 PubChem CID 219024...
6 KB (388 words) - 00:01, 15 March 2024
Voxtalisib Identifiers IUPAC name 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7-one CAS Number 934493-76-2 PubChem CID 16123056...
4 KB (280 words) - 02:28, 8 May 2023