The Grignard reaction (French: [ɡʁiɲaʁ]) is an organometallic chemical reaction in which, according to the classical definition, carbon alkyl, allyl,...
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discovery of the Grignard reaction in 1900 was recognized with the Nobel Prize awarded to Victor Grignard in 1912. Traditionally Grignard reagents are prepared...
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Prize for his discovery of the eponymously named Grignard reagent and Grignard reaction, both of which are important in the formation of carbon–carbon bonds...
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formation of a Grignard reagent. The RM intermediates have been isolated in several cases. The radical is susceptible to diverse reactions. The organometallic...
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Barbier reaction is generated in situ, whereas a Grignard reagent is prepared separately before addition of the carbonyl compound. Unlike many Grignard reagents...
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situ from Grignard reagents containing a hydrogen in beta-position and titanium(IV) alkoxides such as titanium isopropoxide. This reaction was first reported...
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Gomberg–Bachmann reaction Gomberg–Bachmann–Hey reaction Gomberg radical reaction Gould–Jacobs reaction Graebe–Ullmann synthesis Grignard degradation Griesbaum...
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Organometallic chemistry (redirect from Organometallic reaction)
compounds include Gilman reagents, which contain lithium and copper, and Grignard reagents, which contain magnesium. Boron-containing organometallic compounds...
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which was added benzaldehyde and allyl chloride: Compared to Grignard reactions, this reaction is very selective towards aldehydes with large tolerance towards...
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creation of organomagnesium reagents with his student, Victor Grignard. Although Grignard was awarded the Nobel prize in 1912 (along with Sabatier) for...
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Benzoic acid (section From Grignard reagent)
exercise for students to carry out a Grignard reaction, an important class of carbon–carbon bond forming reaction in organic chemistry. Benzyl alcohol...
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Methyl group (section Free radical reactions)
to be stronger. In discussing mechanisms of organic reactions, methyl lithium and related Grignard reagents are often considered to be salts of CH−3; and...
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Ketone (redirect from Haller-Bauer reaction)
methyl ketones from carboxylic acids. Ketones can be prepared by the reaction of Grignard reagents with nitriles, followed by hydrolysis. By decarboxylation...
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Synthesis of New, Chiral β-sec-Amino Alcohols – Diastereodivergent Addition of Grignard Reagents to α-Amino Aldehydes Based on the (all-R)-2-Azabicyclo[3.3.0]octane...
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Chiral auxiliary (section Alkylation reactions)
function with (R)-BINOL, arylglyoxals reacted diastereoselectively with Grignard reagents to afford protected atrolactaldehyde with moderate to excellent...
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This reaction happens via a SET mechanism ( single-electron-transfer mechanism ). If magnesium reacts with an alkyl halide, it forms a Grignard reagent...
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Bouveault aldehyde synthesis (category Carbon-carbon bond forming reactions)
formylation reaction, and is named for French scientist Louis Bouveault. The first step of the Bouveault aldehyde synthesis is the formation of the Grignard reagent...
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Dimethylformamide (category CS1 German-language sources (de))
arenes. Organolithium compounds and Grignard reagents react with DMF to give aldehydes after hydrolysis in a reaction called Bouveault aldehyde synthesis...
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chemistry. They are commonly found as Grignard reagents, formed by reaction of magnesium with haloalkanes. Examples of Grignard reagents are phenylmagnesium bromide...
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by the reaction of a Grignard or organolithium reagent with trialkyltin chlorides. For example, vinyltributyltin is prepared by the reaction of vinylmagnesium...
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Aldehyde (section Bisulfite reaction)
reagents, Grignard reagents, or acetylides, undergo nucleophilic addition reactions, yielding a substituted alcohol group. Related reactions include organostannane...
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while diethyl ether remains the solvent of choice for some reactions (e.g., Grignard reactions), THF fills that role in many others, where strong coordination...
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Organozinc chemistry (redirect from Frankland-Duppa reaction)
less reactive than many other analogous organometallic reagents, such as Grignard and organolithium reagents. In 1848 Edward Frankland prepared the first...
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Carbonyldiimidazole (category CS1 German-language sources (de))
alcohols). The reagent can also be reacted with Grignard reagents to form ketones. A C-C acylation reaction can occur with a malonic ester-type compound...
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Mesitylene (section Reactions)
derivatives, e.g. tetramesityldiiron, are typically prepared from the Grignard reagent (CH3)3C6H2MgBr. Due to its large steric demand, the mesityl group...
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Imine (category CS1 German-language sources (de))
intermediate can be isolated. Primary ketimines can be synthesized via a Grignard reaction with a nitrile. This method is known as Moureu-Mignonac ketimine synthesis...
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Aryl halide (section Reactions)
iodides are "easy" substrates for many reactions such as cross-coupling reactions and conversion to Grignard reagents, but they are much more expensive...
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Nucleophilic addition (category Reaction mechanisms)
the Mannich reaction an enolate ion in an aldol reaction or Baylis–Hillman reaction an organometallic nucleophile in the Grignard reaction or the related...
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Cyclopropanation (category Cheletropic reactions)
Kulinkovich reaction form cyclopropanols via a reaction between esters and Grignard reagents in presence of a titanium alkoxide. The Bingel reaction is a specialised...
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