The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues. Initially, SH3 was described as a conserved sequence...

contain six conserved domains: a N-terminal myristoylated segment, a SH2 domain, a SH3 domain, a linker region, a tyrosine kinase domain, and C-terminal tail...

one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine...

SH3 or SH-3 may refer to: SH3 domain, a protein structural domain thought to be involved in the formation of productive protein-protein binding interactions...

SH2 and SH3, as well as a protein kinase domain with tyrosine phosphorylation activity. Part of the TH domain is folded against the PH domain while the...

Activity of ABL1 protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation...

Src) gene of Rous sarcoma virus. It includes an SH2 domain, an SH3 domain and a tyrosine kinase domain. Two transcript variants encoding the same protein...

of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 2001 [PubMed 11536050]). SASH1 GRCh38:...

enzymatic activities (e.g. kinase) or they serve as binding modules (e.g. the SH3 domain binds to proline-rich sequences in other proteins). Short amino acid sequences...

family) or two domains: an integrin-binding domain and a focal adhesion-binding domain (Fak family). The nRTK Abl possess the SH2 and SH3 domains, but also...

domain of the src viral oncogene, which is itself a tyrosine kinase. See also: SH3 domain. Zinc finger DNA-binding domain (ZnF_GATA): ZnF_GATA domain-containing...

YAP1 was first identified by virtue of its ability to associate with the SH3 domain of Yes and Src protein tyrosine kinases. YAP1 is a potent oncogene, which...

(recombination mediator) OB-folds are structurally similar to Src homology 3 (SH3) domains, with their β-strands superimposing with less than 2 Å difference. This...

SLP-76. PLCg1 binds to LAT through its n-terminal SH2 domain and to SLP-76 via its SH3 domain. Has been shown to interact with CISH which negatively...

not adult tissues. RasGAP contains one SH3 domain and two SH2 domains, a PH domain, a C2 domain, and a GAP domain. RAS p21 protein activator 1 has been...

SH3 and multiple ankyrin repeat domains protein 2 is a protein that in humans is encoded by the SHANK2 gene. Two alternative splice variants, encoding...

In mice, CD146 directly interacts with the SH3 domain of coreceptor-free LCK via its cytoplasmic domain, promoting the LCK autophosphorylation. There...

cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem...

highly conserved SH domains: SH1, SH2, and SH3. The catalytic SH1 domain houses the kinase's active site. The regulatory SH3 and SH2 domains are tightly bound...

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ASAP2 gene. This gene encodes a multidomain...

(November 1996). "Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases: binding partners of SH3 domains?". Protein Sci. 5 (11):...

MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate...

The structure of the SH3 domain of nebulin was determined by protein nuclear magnetic resonance spectroscopy. The SH3 domain from nebulin is composed...

sequence variation being located to the linker regions between the SH3 and SH2 domains, and are 96% identical to their human counterparts. While human nck-1...

SH3 domain-binding protein 5 is a protein that in humans is encoded by the SH3BP5 gene. SH3BP5 has been shown to interact with Bruton's tyrosine kinase...

Adolphs J, Hanusch H, Brandis M (Nov 1997). "A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1". Nat Genet. 17 (2): 149–53...

specifically to the Ras-GTPase-activating protein by associating with its SH3 domain, but this interaction has recently been challenged. Several alternatively...

subfamily members contain an SH3 domain, and the MIM/ABBA subfamily proteins contain a WH2 (WASP-homology 2) domain. The vertebrate SH3-containing subfamily is...

SH3 and SYLF domain containing 1 is a protein that in humans is encoded by the SH3YL1 gene. GRCh38: Ensembl release 89: ENSG00000035115 – Ensembl, May...

times in tandem (“cortactin repeats”); a proline-rich region; and an SH3 domain. This basic structure is highly conserved among all species that express...