Selegiline, also known as L-deprenyl and sold under the brand names Eldepryl, Zelapar, and Emsam among others, is a medication which is used in the treatment...
208 KB (20,188 words) - 18:33, 13 December 2024
pharmacology of selegiline pertains to the pharmacodynamic and pharmacokinetic properties of the antiparkinsonian and antidepressant selegiline (L-deprenyl)...
139 KB (14,124 words) - 01:27, 16 December 2024
Levoamphetamine (category Selegiline)
levoamphetamine is a known active metabolite of certain other drugs, such as selegiline (L-deprenyl). Levoamphetamine has been used in the treatment of attention...
68 KB (6,381 words) - 18:41, 13 December 2024
pseudoephedrine), antidepressants (e.g. bupropion), antiparkinson agents (e.g., selegiline), and vasopressors (e.g., ephedrine), among others. Many of these psychoactive...
54 KB (5,178 words) - 18:43, 13 December 2024
Levmetamfetamine (category Selegiline)
catecholamine releasing activity. It is 1- to 10-fold less potent than selegiline but is 3- to 5-fold more potent than dextromethamphetamine in this action...
51 KB (5,047 words) - 17:31, 11 December 2024
complicated by panic disorder or hysteroid dysphoria. Newer MAOIs such as selegiline (typically used in the treatment of Parkinson's disease) and the reversible...
37 KB (4,011 words) - 23:48, 17 December 2024
Desmethylselegiline (category Selegiline)
an active metabolite of selegiline, a medication used in the treatment of Parkinson's disease and depression. Like selegiline, DMS is a monoamine oxidase...
19 KB (1,485 words) - 00:57, 20 August 2024
(PPAP; developmental code name MK-306) is an experimental drug related to selegiline which acts as a catecholaminergic activity enhancer (CAE). PPAP is a CAE...
29 KB (2,978 words) - 04:45, 18 November 2024
Deprenyl (category Selegiline)
N-propargylmethamphetamine, is the racemic mixture of D-deprenyl and L-deprenyl (selegiline). It was discovered in 1961 in Hungary at Chinoin Pharmaceutical Company...
7 KB (517 words) - 21:14, 17 October 2024
brain. Rasagiline shows pharmacological differences from the related drug selegiline, including having no amphetamine-like metabolites, monoamine-releasing...
91 KB (8,979 words) - 08:35, 22 December 2024
Monoaminergic activity enhancer (category Selegiline)
serotonergic activity. Selegiline's metabolite desmethylselegiline has also been found to be active as a CAE. Aside from selegiline and its metabolites,...
57 KB (5,873 words) - 22:03, 24 November 2024
substituted amphetamine designer drug. It is the 4-fluorinated derivate of selegiline. 4-Fluoroselegiline is a selective and irreversible inhibitor of monoamine...
6 KB (331 words) - 00:14, 17 November 2024
phenethylamine-derived selegiline (L-deprenyl) and phenylpropylaminopentane (PPAP). This suggests that different MAEs like BPAP and selegiline may not be identical...
11 KB (1,210 words) - 22:54, 18 November 2024
and the MAO-B inhibitor and catecholaminergic activity enhancer selegiline. Selegiline shows a complicated U-shaped dose–response curve in its efficacy...
20 KB (1,888 words) - 20:12, 14 November 2024
developmental code name FPFS-1169) is an experimental drug related to selegiline which acts as a monoaminergic activity enhancer (MAE). It is orally active...
30 KB (2,838 words) - 23:43, 29 November 2024
non-selective MAOI linezolid and the potent selective MAO-B inhibitor selegiline (as a transdermal patch) on the pharmacokinetics of pseudoephedrine. This...
148 KB (13,455 words) - 07:32, 19 December 2024
enantiomers of deprenyl and is the opposite enantiomer of l-deprenyl (selegiline). l-Deprenyl, also an MAO-B inhibitor, metabolizes to l-amphetamine and...
7 KB (501 words) - 21:14, 17 October 2024
it lacks significant monoamine oxidase inhibition. In addition, unlike selegiline and its amphetamine metabolites, it lacks monoamine reuptake-inhibiting...
9 KB (692 words) - 12:22, 15 December 2024
Carbidopa/levodopa/entacapone may be combined with the drugs rasagiline or selegiline. These drugs are a different type of MAO inhibitor known as selective...
10 KB (734 words) - 03:29, 28 September 2024
behavioral disinhibition and reduced anxiety-like behaviors. Treatment with selegiline, an MAO-B inhibitor, in rats has been shown to prevent many age-related...
37 KB (4,431 words) - 19:04, 30 September 2024
phentermine, mephentermine, tranylcypromine, bupropion, methoxyphenamine, selegiline, amfepramone (diethylpropion), pyrovalerone, MDMA (ecstasy), and DOM (STP)...
36 KB (1,770 words) - 19:39, 11 December 2024
Management of Parkinson's disease (section Selegiline)
oscillations in some patients. Dietary protein restriction and the use of selegiline and bromocriptine may also temporarily improve motor fluctuations. New...
73 KB (8,626 words) - 01:57, 1 December 2024
serotonin and the catecholamines. It is also in contrast to PPAP and selegiline, which act exclusively as catecholaminergic activity enhancers (CAEs)...
13 KB (1,306 words) - 02:15, 12 November 2024
Ibopamine Indanylamphetamine Iofetamine Isoetarine Isoprenaline L-Deprenyl (Selegiline) Lefetamine Lisdexamfetamine Lophophine MBDB MDA (tenamfetamine) MDBU...
163 KB (15,931 words) - 07:08, 22 December 2024
are important drug targets, targeted by MAO inhibitors (MAOIs) such as selegiline. Glutamate dehydrogenase play an important role in oxidative deamination...
4 KB (395 words) - 21:39, 29 June 2024
atomoxetine and reboxetine Norepinephrine releasing agents like ephedrine and selegiline (via its metabolites) Dopamine D1 receptor positive allosteric modulators...
15 KB (1,330 words) - 01:33, 18 December 2024
József Knoll (category Selegiline)
developing the antiparkinsonian and antidepressant drug selegiline (L-deprenyl). He developed selegiline in the 1960s and subsequently studied the drug and...
7 KB (574 words) - 11:26, 13 November 2024
Ibopamine Indanylamphetamine Iofetamine Isoetarine Isoprenaline L-Deprenyl (Selegiline) Lefetamine Lisdexamfetamine Lophophine MBDB MDA (tenamfetamine) MDBU...
181 KB (16,723 words) - 18:35, 17 December 2024
Reversible: Eprobemide Metralindole Minaprine‡ Moclobemide Pirlindole Tetrindole Toloxatone MAOBTooltip Monoamine oxidase B-selective Irreversible: Selegiline...
139 KB (12,748 words) - 16:13, 22 December 2024
antidepressants (e.g. bupropion and phenelzine), antiparkinson agents (e.g., selegiline), and vasopressors (e.g., ephedrine), among others. Many of these psychoactive...
28 KB (701 words) - 15:15, 16 December 2024