Self-amplifying RNA (saRNA), also termed self-replicating RNA (srRNA), is a type of mRNA molecule engineered to replicate itself within host cells, enhancing...
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MRNA vaccine (redirect from Rna vaccine)
exogenous mRNA (such as a vaccine) even if it could enter the nucleus. mRNA vaccines use either non-amplifying (conventional) mRNA or self-amplifying mRNA. Pfizer–BioNTech...
77 KB (7,878 words) - 16:22, 10 October 2024
COVID-19 vaccine (redirect from COVID-19 mRNA vaccine (nucleoside-modified))
use RNA to stimulate an immune response. When introduced into human tissue, the vaccine contains either self-replicating RNA or messenger RNA (mRNA), which...
202 KB (23,012 words) - 23:44, 14 October 2024
County, Sweden Small activating RNA (saRNA) Sarna (drug), see List of drugs: S-Sd Self-amplifying RNA (also termed saRNA or SAM) Sarna (religion) All pages...
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immune responses. In these contexts, replicons have been termed self-amplifying RNA. The replicons lack the ability to transmit to new cells as they...
32 KB (3,384 words) - 07:24, 20 August 2024
Rolling circle replication (redirect from Rolling circle amplification)
RNA, such as plasmids, the genomes of bacteriophages, and the circular RNA genome of viroids. Some eukaryotic viruses also replicate their DNA or RNA...
24 KB (2,920 words) - 14:34, 16 July 2024
loop-mediated isothermal amplification (RT-LAMP) is a one step nucleic acid amplification method to multiply specific sequences of RNA. It is used to diagnose...
15 KB (1,765 words) - 01:04, 18 June 2024
ARCT-154 (category RNA vaccines)
second one being administered 28 days after the first shot. It is a self-amplifying mRNA vaccine. The vaccine candidate can be made in a lyophilized powder...
14 KB (1,319 words) - 10:36, 24 September 2024
The RNA world is a hypothetical stage in the evolutionary history of life on Earth in which self-replicating RNA molecules proliferated before the evolution...
92 KB (10,725 words) - 01:04, 18 October 2024
Single-cell sequencing (redirect from Single-cell RNA-sequencing)
has been published. Multiple displacement amplification (MDA) is a widely used technique, enabling amplifying femtograms of DNA from bacterium to micrograms...
74 KB (8,559 words) - 04:14, 13 October 2024
Ribozyme (redirect from Catalytic RNA)
the RNA world hypothesis, which suggests that RNA may have been important in the evolution of prebiotic self-replicating systems. The most common activities...
43 KB (5,174 words) - 14:33, 4 October 2024
Polymerase chain reaction (redirect from PCR amplification)
Transcription PCR (RT-PCR): for amplifying DNA from RNA. Reverse transcriptase reverse transcribes RNA into cDNA, which is then amplified by PCR. RT-PCR is widely...
89 KB (11,135 words) - 11:52, 26 August 2024
the sale of 5,000,000 shares. It started a Phase 1 trial of its self-amplifying mRNA second generation SARS-CoV-2 vaccine, GRT-R910, in the NIHCR Manchester...
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A small conditional RNA (scRNA) is a small RNA molecule or complex (typically less than approximately 100 nt) engineered to interact and change conformation...
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Complementary DNA (section RNA purification)
reverse transcribed (via reverse transcriptase) from an RNA (e.g., messenger RNA or microRNA). cDNA exists in both single-stranded and double-stranded...
19 KB (2,275 words) - 03:38, 13 October 2024
RNA-Seq is a technique that allows transcriptome studies (see also Transcriptomics technologies) based on next-generation sequencing technologies. This...
164 KB (20,376 words) - 21:20, 25 September 2024
different types of IVT mRNA-based vaccine development for infectious diseases. One of the successful types is using self-amplifying IVT mRNA that has sequences...
77 KB (8,886 words) - 09:03, 10 June 2024
MicroRNA (miRNA) biosensors are analytical devices that involve interactions between the target miRNA strands and recognition element on a detection platform...
64 KB (7,163 words) - 19:55, 26 June 2024
Abiogenesis (section The RNA world)
descends from an RNA world, although other self-replicating and self-catalyzing molecules may have preceded RNA. Other approaches ("metabolism-first" hypotheses)...
204 KB (21,049 words) - 12:57, 8 October 2024
underlying order-generating processes of self-organization in the non-biological systems and in replicating RNA are basically similar. In his 1995 conference...
61 KB (6,808 words) - 16:35, 22 July 2024
Transcription (biology) (redirect from RNA transcription)
segment of DNA into RNA. The segments of DNA transcribed into RNA molecules that can encode proteins produce messenger RNA (mRNA). Other segments of DNA...
58 KB (6,787 words) - 18:50, 13 October 2024
ribonucleic acid (RNA) molecules, microRNA (miRNA) and small interfering RNA (siRNA), are central to components to the RNAi pathway. Once mRNA is degraded,...
141 KB (15,474 words) - 15:59, 8 October 2024
transfer RNA (tRNA) and messenger RNA (mRNA) to process and translate the latter into proteins. Ribosomal RNA is the predominant form of RNA found in...
60 KB (7,195 words) - 13:36, 12 September 2024
million to Imperial College in London, to fund the development of a "self-amplifying RNA vaccine platform" that CEPI said: "would enable a tailored vaccine...
57 KB (5,312 words) - 07:40, 20 September 2024
poly-adenylated mRNAs. Besides oligo(dT) tail and spatial barcode, which indicates the x and y position on the arrayed slide, the probe contains an amplification and...
56 KB (6,518 words) - 02:53, 21 October 2024
Virusoid (redirect from Circular satellite RNAs)
Virusoids are circular single-stranded RNA(s) dependent on viruses for replication and encapsidation. The genome of virusoids consists of several hundred...
23 KB (2,615 words) - 17:40, 14 May 2024
transcribed into RNA and amplified. Several TAS commercial variations are available including; transcription-mediated amplification (TMA), and self-sustaining...
9 KB (1,138 words) - 01:04, 4 March 2024
1/2/3 trial for next-generation mRNA COVID-19 vaccine". Biopharma Reporter. 2 August 2021. "The ARCT-154 Self-Amplifying RNA Vaccine Efficacy Study (ARCT-154-01)...
95 KB (18,965 words) - 23:35, 15 September 2024
CRISPR (category Non-coding RNA)
Marraffini LA, Sontheimer EJ (January 2010). "Self versus non-self discrimination during CRISPR RNA-directed immunity". Nature. 463 (7280): 568–571...
128 KB (13,446 words) - 14:21, 19 October 2024
Variants of PCR (redirect from Isothermal amplification)
used to measure the specific amount of target DNA (or RNA) in a sample. By measuring amplification only within the phase of true exponential increase, the...
32 KB (4,102 words) - 05:25, 7 February 2024