Subtilisin is a protease (a protein-digesting enzyme) initially obtained from Bacillus subtilis. Subtilisins belong to subtilases, a group of serine proteases...
12 KB (1,203 words) - 19:42, 29 August 2024
PCSK9 (redirect from Proprotein convertase subtilisin/kexin type 9)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1. It is the 9th member of the proprotein...
69 KB (7,354 words) - 16:56, 11 June 2024
Serine protease (section Subtilisin-like)
categories based on their structure: chymotrypsin-like (trypsin-like) or subtilisin-like. The MEROPS protease classification system counts 16 superfamilies...
22 KB (2,343 words) - 20:13, 29 August 2024
(and should not be pronounced as such), but a serine protease of the subtilisin family (99.5% identical with aprE). Rather, it is named for the fact that...
6 KB (633 words) - 21:46, 14 September 2024
DNA polymerase I from E. coli is enzymatically cleaved by the protease subtilisin. First reported in 1970, it retains the 5' → 3' polymerase activity and...
4 KB (473 words) - 16:30, 29 May 2024
family S8, furin is a subtilisin-like peptidase. The protein encoded by this gene is an enzyme that belongs to the subtilisin-like proprotein convertase...
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Proprotein convertase 1 (redirect from Proprotein subtilisin/kexin type 1)
substrate). It is related to the bacterial enzyme known as subtilisin. There are nine subtilisin homologs in mammals; in addition to proprotein convertase...
5 KB (600 words) - 15:33, 26 August 2023
SSI protease inhibitor (redirect from Streptomyces subtilisin inhibitor)
In molecular biology the protein SSI is a Subtilisin inhibitor-like which stands for Streptomyces subtilisin inhibitor. This is a protease inhibitor. These...
4 KB (448 words) - 01:44, 10 June 2024
a fully human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9). PCSK9 is a protein that targets LDL receptors for...
17 KB (1,472 words) - 10:46, 21 September 2024
bacterial dysentery; its efficacy (probably attributable to the antibiotic subtilisin from Bacillus subtilis) was anecdotally confirmed by German soldiers in...
22 KB (2,184 words) - 00:40, 9 October 2024
Subtilases are a family of subtilisin-like serine proteases. They appear to have independently and convergently evolved an Asp/Ser/His catalytic triad...
5 KB (645 words) - 22:56, 25 April 2024
licheniformis one of the most important bacteria in industrial enzyme production. Subtilisin Carlsberg (P00780) secreted by B. licheniformis is used as a detergent...
17 KB (1,776 words) - 03:04, 15 September 2024
Searching for "Subtilisin" returns the protein, "Subtilisin from Bacillus subtilis, carlsberg", with the following lineage. Subtilisin from Bacillus subtilis...
22 KB (2,564 words) - 19:34, 16 August 2024
Ottesen M, Richards FM (February 1955). "Degradation of ribonuclease by subtilisin". Biochimica et Biophysica Acta. 16 (2): 297–299. doi:10.1016/0006-3002(55)90224-9...
102 KB (11,386 words) - 22:54, 1 October 2024
site serines and are part of inhibitors for porcine pancreatic lipase, subtilisin and the protease Kex2. Furthermore, boronic acid derivatives constitute...
26 KB (2,605 words) - 12:51, 11 October 2024
preventing the enzyme from sucking in the chain past the first residue. 1969 – Subtilisin (PDB file 1sbt ) was a second type of serine protease with a near-identical...
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organisation of acid-base-nucleophile in different protease superfamilies. Shown are the triads of subtilisin, prolyl oligopeptidase, TEV protease, and papain....
57 KB (5,772 words) - 05:00, 12 September 2024
Digestive aid Urokinase Pharmaceutical Anticoagulant β-Lactamase Pharmaceutical Penicillin allergy treatment Subtilisin Consumer Goods Laundry detergent...
15 KB (1,580 words) - 20:41, 27 August 2024
production of alpha amylase used in starch hydrolysis and the protease subtilisin used in detergents. B. subtilis is a valuable model for bacterial research...
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antibody Type Whole antibody Source Human Target Proprotein convertase subtilisin/kexin type 9 (PCSK9) Clinical data Trade names Praluent AHFS/Drugs.com...
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for its broad specificity. This enzyme belongs to Peptidase family S8 (subtilisin). The molecular weight of Proteinase K is 28,900 daltons (28.9 kDa). Activated...
10 KB (1,063 words) - 20:45, 11 September 2024
sp, subtilisin-like pernisine from Aeropyrum pernix, alkaline protease from Nocardiopsis sp, nattokinase from B. subtilis, engineered subtilisins from...
99 KB (10,733 words) - 11:44, 7 October 2024
specifically, inhibiting translation of the protein termed proprotein convertase subtilisin/kexin type 9 (PCSK9). Small interfering RNA molecules (siRNAs) are designed...
21 KB (1,744 words) - 14:15, 24 April 2024
2019. Bogacheva AM, Rudenskaya GN, Preusser A, et al. (1999). "A new subtilisin-like proteinase from roots of the dandelion Taraxacum officinale Webb...
49 KB (4,645 words) - 04:02, 21 September 2024
killer toxin precursors. The human homolog is PCSK4. It is a family of subtilisin-like peptidases. Even though there are a few prokaryote kexin-like peptidases...
5 KB (504 words) - 22:17, 1 September 2023
application. For example, commonly used laundry detergents may contain subtilisin, whose wild-type form has a methionine that can be oxidized by bleach...
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similar strategy of employing an inactive zymogen or prezymogen is used. Subtilisin, which is produced by Bacillus subtilis, is produced as preprosubtilisin...
34 KB (4,246 words) - 02:50, 14 August 2024
Simultaneously, the structures of the evolutionarily unrelated papain and subtilisin proteases were found to contain analogous triads. The 'charge-relay' mechanism...
57 KB (5,790 words) - 20:33, 13 May 2024
Proprotein convertase subtilisin/kexin type 1 inhibitor is a protein by the name of proSAAS that in humans is encoded by the PCSK1N gene. This protein...
4 KB (582 words) - 05:15, 22 July 2023
work, published in 1993, she used the method to engineer a version of subtilisin E that was active in the organic solvent DMF, a highly unnatural environment...
46 KB (4,360 words) - 00:39, 10 October 2024