Tamoxifen, sold under the brand name Nolvadex among others, is a selective estrogen receptor modulator used to prevent breast cancer in women and men...

situ. Tamoxifen treatment is also used for the treatment of osteoporosis and blood lipids in postmenopausal women. Adverse effects of tamoxifen include...

N-Desmethyltamoxifen (developmental code name ICI-55,548) is a major metabolite of tamoxifen, a selective estrogen receptor modulator (SERM). N-Desmethyltamoxifen...

the treatment and prevention of breast cancer in women. The Arimidex, Tamoxifen, Alone or in Combination (ATAC) trial was of localized breast cancer and...

Nellie Richardson (1919-1998) was an organic chemist who first synthesised Tamoxifen in England in 1962. She was born on 1 June 1919 and died in September...

women with early breast cancer who have received prior standard adjuvant tamoxifen therapy; first and second-line treatment of postmenopausal women with...

treatment of some cases of gynecomastia but it is not as effective as tamoxifen or raloxifene for this indication. It has shown variable results for gynecomastia...

effective than tamoxifen or raloxifene. Tamoxifen may be used to treat gynecomastia in adults and of the medical treatments used, tamoxifen is the most effective...

women with breast cancer. Tamoxifen (a SERM) traditionally was the drug treatment of choice, but the ATAC trial (Arimidex, Tamoxifen, Alone or in Combination)...

Tamoxifen and Raloxifene (STAR) is a clinical trial from the early 2000s designed determine how the drug raloxifene compares with the drug tamoxifen in...

positive early breast cancer who have received two to three years of tamoxifen and are switched to it for completion of a total of five consecutive years...

documented rarely with the selective estrogen receptor modulators (SERMs) tamoxifen and raloxifene. The phenomenon indicates that these agents can somehow...

Further, these knockouts can be made inducible. In several mouse studies, tamoxifen is used to induce the expression of Cre recombinase. In this case, Cre...

idiopathic sclerosing mesenteritis, medications such as corticosteroids, tamoxifen and thalidomide have been used. The epidemiology of Idiopathic sclerosing...

120 mg/m2/day. In the Study of Tamoxifen and Raloxifene (STAR) trial, 60 mg/day raloxifene was 78% as effective as 20 mg/day tamoxifen in preventing non-invasive...

active metabolite of tamoxifen and has been found to be effective in patients that have failed previous hormonal therapies (tamoxifen, aromatase inhibitors...

Metastatic breast cancer, tamoxifen can be prescribed to selectively block estrogen's effect on certain cells. SERMs like tamoxifen attach to receptors on...

gefitinib-resistant NSCLC cell lines. In breast cancer, the acquisition of tamoxifen resistance is another major therapeutic problem. It has been shown that...

Antiestrogens include selective estrogen receptor modulators (SERMs) like tamoxifen, clomifene, and raloxifene, the ER silent antagonist and selective estrogen...

Introduction of laser therapy in treatment of cancer 1960  – Invention of tamoxifen breast cancer anti-estrogen (SERM) hormonal therapy drug 1961  – Vincristine...

toxicities of tamoxifen. Tamoxifen has been a very effective drug for the treatment of estrogen receptor-positive breast cancer. But tamoxifen has certain...

taking pills that contain estrogen without progesterone, a history of tamoxifen use, late menopause, and a family history of the condition. Risk factors...

N,N-Desmethyltamoxifen is a metabolite of tamoxifen, a selective estrogen receptor modulator (SERM). It is formed from N-desmethyltamoxifen and is an...

surgery. Tamoxifen has been proposed as part of a treatment plan. Treatment is directed to surgical relief of compressive symptoms. Tamoxifen may also...

treating these men with a selective estrogen receptor modulator, tamoxifen. Tamoxifen acts indirectly to inhibit ER signaling in breast cancer cells. Klinefelter...

effective than tamoxifen in the treatment of breast cancer in two phase III clinical trials. Droloxifene is an analogue of tamoxifen, specifically 3-hydroxytamoxifen...

reaction due to CYP3A4 includes tamoxifen, which is hydroxylated to 4-hydroxy-tamoxifen and then dehydrated to 4-hydroxy-tamoxifen quinone methide. Two mechanisms...

recombinase, resulting in Cre becoming specifically activated by tamoxifen. In the absence of tamoxifen, CreER will result in the shuttling of the mutated recombinase...

100 film edge marking Tandem Mirror Experiment TMX Finance, US company Tamoxifen, breast cancer medication Trans Mountain Expansion Project in Trans Mountain...

Medications in use for this effect are mainly clomifene citrate and tamoxifen (both being selective estrogen-receptor modulators), as well as letrozole...