Thrombospondins (TSPs) are a family of secreted glycoproteins with antiangiogenic functions. Due to their dynamic role within the extracellular matrix...
6 KB (643 words) - 17:31, 26 December 2022
Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene. Thrombospondin 1 is a subunit of a disulfide-linked homotrimeric...
19 KB (2,345 words) - 04:52, 3 June 2024
ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13)—also known as von Willebrand factor-cleaving protease (VWFCP)—is...
12 KB (1,420 words) - 09:40, 14 January 2024
Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene. The protein encoded by this gene belongs to the thrombospondin family. It is...
9 KB (1,050 words) - 04:06, 17 June 2024
Thrombospondin-4 is a protein that in humans is encoded by the THBS4 gene. The protein encoded by this gene belongs to the thrombospondin protein family...
6 KB (709 words) - 23:19, 27 March 2024
Thrombospondin-3 (TSP3) is a protein that in humans is encoded by the THBS3 gene. The protein encoded by this gene belongs to the thrombospondin family...
8 KB (847 words) - 02:36, 29 November 2023
CD47 (section Thrombospondin (TSP))
superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD-47 acts as...
36 KB (4,214 words) - 05:29, 27 May 2024
Cagla Eroglu (category Thrombospondins)
specifically through the release of thrombospondin. A further in depth analysis into the role of thrombospondin and their receptors α2δ-1, which Eroglu...
20 KB (2,179 words) - 22:45, 7 November 2023
macrophages where the latent TGF-β complex is bound to CD36 via its ligand, thrombospondin-1 (TSP-1). Inflammatory stimuli that activate macrophages enhance the...
70 KB (8,485 words) - 08:12, 19 May 2024
disease. MiR-27b also targets Thrombospondin-1, an antiangiogenic protein. Reduction in miR-27b increases Thrombospondin-1 levels, which decreases angiogenesis...
4 KB (415 words) - 04:07, 22 January 2021
common. Examples of TAF-derived ECM components include Tenascin and Thrombospondin-1 (TSP-1), which can be found in sites of chronic inflammation and carcinomas...
14 KB (1,677 words) - 11:44, 29 April 2024
integrally involved in inflammation. It cleaves fibrin, fibronectin, thrombospondin, laminin, and von Willebrand factor. Plasmin, like trypsin, belongs...
15 KB (1,821 words) - 02:15, 10 March 2024
type V, alpha 2 (COL5A2) Mucin 2 (MUC2) Mucin 5B (MUC5B) Thrombospondin 1 (THBS1) Thrombospondin 2 (THBS2) SCO-spondin (SSPO) CCN1: Cysteine-rich angiogenic...
5 KB (570 words) - 01:53, 31 December 2020
ADAM metallopeptidase with thrombospondin type 1 motif 6 is a protein that in humans is encoded by the ADAMTS6 gene. This gene encodes a member of the...
3 KB (392 words) - 02:38, 26 January 2023
region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number...
1 KB (148 words) - 13:59, 24 January 2024
cell surface proteins. CD36 binds many ligands including collagen, thrombospondin, erythrocytes parasitized with Plasmodium falciparum, oxidized low density...
44 KB (5,085 words) - 19:02, 7 June 2024
ADAMTS (short for a disintegrin and metalloproteinase with thrombospondin motifs) is a family of multidomain extracellular protease enzymes. 19 members...
5 KB (409 words) - 23:57, 18 February 2024
ADAM metallopeptidase with thrombospondin type 1 motif, 17 is a protein that in humans is encoded by the ADAMTS17 gene. This gene encodes a member of the...
6 KB (727 words) - 02:54, 28 November 2023
metalloproteinase with thrombospondin motifs 1 ADAMTS5: encoding enzyme a disintegrin and metalloproteinase with thrombospondin motifs 5 ADARB1: encoding...
34 KB (3,086 words) - 10:35, 27 June 2024
chain fatty acids, anionic phospholipids, collagen types I, IV and V, thrombospondin and Plasmodium falciparum infected erythrocytes. CD molecules are leucocyte...
2 KB (149 words) - 01:00, 16 March 2022
MED. Lack of COMP was not compensated for by any other protein in the thrombospondin family. This study confirmed that the disease is not caused by reduced...
23 KB (2,399 words) - 04:17, 17 December 2023
PLA2R autoantibodies. In 2014, a second autoantigen was discovered, the thrombospondin type 1 domain-containing 7A (THSD7A) system that might account for an...
22 KB (2,291 words) - 16:52, 1 November 2023
A disintegrin and metalloproteinase with thrombospondin motifs 1 is an enzyme that in humans is encoded by the ADAMTS1 gene. This gene encodes a member...
8 KB (1,009 words) - 17:46, 26 December 2022
fibulins, osteopontin, periostin, SPARC family members, tenascin(s), and thrombospondins. Many of these proteins have important functions in wound healing and...
3 KB (264 words) - 04:58, 15 December 2020
in selenium and selenium uptake mechanisms result in brain damage. Thrombospondin is a protein found in the extracellular matrix that competes with reelin...
27 KB (3,439 words) - 10:00, 27 March 2024
Thrombospondin type-1 domain-containing protein 1 is a protein that in humans is encoded by the THSD1 gene. The protein encoded by this gene contains a...
4 KB (423 words) - 01:33, 4 March 2023
neurexins (NRXN1, NRXN2, NRXN3), slit homologs (SLIT1, SLIT2, SLIT3), thrombospondins (THBS1, THBS2, THBS3, THBS4, TSPEAR), agrin (AGRIN), chondroitin sulfate...
31 KB (3,430 words) - 03:11, 4 July 2024
enzyme ADAMTS13 (acronym of "a disintegrin-like and metalloprotease with thrombospondin type 1 motif no. 13"). It is a metalloproteinase that cleaves VWF between...
17 KB (2,121 words) - 20:13, 5 June 2024
A disintegrin and metalloproteinase with thrombospondin motifs 5 also known as ADAMTS5 is an enzyme that in humans is encoded by the ADAMTS5 gene. ADAMTS5...
12 KB (1,458 words) - 16:40, 5 June 2024
that are members of the ADAMTS (A Disintegrin And Metalloprotease with Thrombospondin Motifs) family. Aggrecanases act on large proteoglycans known as aggrecans...
3 KB (296 words) - 16:35, 12 May 2024