The thromboxane receptor (TP) also known as the prostanoid TP receptor is a protein that in humans is encoded by the TBXA2R gene, The thromboxane receptor...

asthma. Thromboxane acts by binding to any of the thromboxane receptors, G-protein-coupled receptors coupled to the G protein Gq. Thromboxane is a vasoconstrictor...

increases platelet aggregation. This is achieved by activating the thromboxane receptor, which results in platelet-shape change, inside-out activation of...

well as regulating the contraction of smooth muscle tissue. Conversely, thromboxanes (produced by platelet cells) are vasoconstrictors and facilitate platelet...

a thromboxane synthase inhibitor and as a thromboxane receptor antagonist. The human thromboxane A (TXA) synthase is a 60 kDa cytochrome P450 protein with...

is a precursor in the formation of leukotrienes, prostaglandins, and thromboxanes. Together with omega−3 fatty acids and other omega−6 fatty acids, arachidonic...

from thromboxane A2 (TXA2) binding (leading to platelet activation and subsequent coagulation). PGI2 also binds to endothelial prostacyclin receptors, and...

Walsh; et al. (2005-08-01) [Published on Journal website 2005-07-26]. "Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves...

dilation of blood vessels stimulating platelet aggregation binds to thromboxane receptor on platelets' cell membranes to trigger platelet migration and adhesion...

Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE...

Ifetroban is a potent and selective thromboxane receptor antagonist. It has been studied in animal models for the treatment of cancer metastasis, myocardial...

third CysLTR. Eicosanoid receptor Oxoeicosanoid receptor Prostaglandin receptor Thromboxane receptor Kanaoka Y, Maekawa A, Austen KF (2013). "Identification...

PMID 8542839. Lees P, Ewins CP, Taylor JB, Sedgwick AD (1987). "Serum thromboxane in the horse and its inhibition by aspirin, phenylbutazone and flunixin"...

PGH1, which in turn forms PGE1 and the thromboxane TXA1. Both PGE11 and TXA1 are anti-inflammatory; thromboxane TXA1, unlike its series-2 variant, induces...

that high-dose naproxen induced near-complete suppression of platelet thromboxane throughout the dosing interval and appeared not to increase cardiovascular...

Bronica) is a thromboxane A2 (TXA2) receptor (TP receptor) antagonist used primarily in the treatment of asthma. It was the first TP receptor antagonist...

Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE...

prostaglandins (which are mediators of pain, inflammation, and fever) and to thromboxane A2 (which stimulates platelet aggregation, leading to the formation of...

Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE...

inhibited by nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin. Thromboxane A2, the major product of COX-1 in platelets, induces platelet aggregation...

are divided into four generations based on their molecular structure and receptor selectivity. The basic structure of the hydrophobic retinoid molecule consists...

prostaglandin-endoperoxide synthase, PTGS) enzyme required for prostaglandin and thromboxane synthesis. Aspirin acts as an acetylating agent where an acetyl group...

the precursor to some prostaglandins, leukotrienes (LTA, LTB, LTC), thromboxane (TXA) and the N-acylethanolamine (NAE) arachidonoylethanolamine (AEA:...

in its actions is the ecto-5'-nucleotidase (e-5′NT/CD73)/adenosine A2A receptor pathway. Nimesulide is absorbed rapidly following oral administration....

Fazekas AG, Tremblay S, Mersereau WA (December 1988). "Progesterone receptors regulate gallbladder motility". The Journal of Surgical Research. 45 (6):...

Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE...

Protease-activated receptor-1 antagonists (which inhibit the protease-activated receptor 1 a.k.a. PAR-1) Vorapaxar (Zontivity) Thromboxane inhibitors Thromboxane receptor...

prostaglandins (mediators of inflammatory and anaphylactic reactions), the thromboxanes (mediators of vasoconstriction), and the prostacyclins (active in the...

Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE...

Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE...