Tissue-type plasminogen activator, short name tPA, is a protein that facilitates the breakdown of blood clots. It acts as an enzyme to convert plasminogen...
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as the principal inhibitor of tissue-type plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and hence fibrinolysis (the physiological...
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name Activase among others, is a biosynthetic form of human tissue-type plasminogen activator (t-PA). It is a thrombolytic medication used to treat acute...
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Urokinase (redirect from Urokinase-type plasminogen activator)
Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals. The human urokinase protein...
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There are two main plasminogen activators: urokinase (uPA) and tissue plasminogen activator (tPA). Tissue plasminogen activators are used to treat medical...
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serpin superfamily, is a coagulation factor that inactivates tissue plasminogen activator and urokinase. It is present in most cells, especially monocytes/macrophages...
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Plasmin (redirect from Plasminogen)
for plasminogen activation by tissue plasminogen activator. Urokinase plasminogen activator receptor (uPAR) is a cofactor for plasminogen activation by...
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Urokinase receptor (redirect from Urokinase plasminogen activator receptor)
The Urokinase receptor, also known as urokinase plasminogen activator surface receptor (uPAR) or CD87 (Cluster of Differentiation 87), is a protein encoded...
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reaction. Tissue-type plasminogen activator (tPA) is a serine proteinase that transforms plasminogen into its activated form, plasmin. Tissue-type plasminogen's...
14 KB (1,851 words) - 23:51, 23 August 2023
Plasminogen activator Pla (EC 3.4.23.48) is an enzyme. This enzyme catalyses the following chemical reaction Converts human Glu-plasminogen to plasmin...
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Institute of Neurological Disorders and Stroke (NINDS) Recombinant Tissue Plasminogen Activator (rt-PA) for Acute Stroke Trial and was first published by neurologist...
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Peterson ED, Schwamm LH (February 2011). "Timeliness of tissue-type plasminogen activator therapy in acute ischemic stroke: patient characteristics...
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Adiponectin Resistin Plasminogen activator inhibitor-1 (PAI-1) TNFα IL-6 Leptin Estradiol (E2) Adipose tissues also secrete a type of cytokines (cell-to-cell...
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links the C-terminal adjacent strands of the domain. In human tissue plasminogen activator chain A the FN1 domain together with the following epidermal...
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breakdown. Substances such as antithrombin III, thrombomodulin, tissue-type plasminogen activator and urokinase dissolve formed blood clots and prostacyclin...
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Lawrence DA (2004). "Neuroserpin: a selective inhibitor of tissue-type plasminogen activator in the central nervous system". Thromb. Haemost. 91 (3): 457–64...
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integrins, annexin II, C-met receptor, NG2 proteoglycan, tissue-type plasminogen activator, chondroitin sulfate proteoglycans, and CD26. Additionally...
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Hereditary angioedema (redirect from C1 esterase deficiency, (type 2 with ascites))
angioedema type 3 (hereditary angioedema with normal C1 inhibitor levels) is associated with mutations in genes for Factor XII, angiopoietin 1, plasminogen or...
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he was involved with the first patient who was administered tissue plasminogen activator (t-PA) in 1984, a genetically engineered protein. In 1996, he...
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formation but normal fibrin-facilitated plasminogen activation catalyzed by tissue-type plasminogen activator". The Journal of Clinical Investigation...
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Coagulation (redirect from Tissue factor pathway)
shrinkage of the clot volume. Plasminogen activators, such as tissue plasminogen activator (t-PA), activate plasminogen into plasmin, which promotes lysis of...
65 KB (6,544 words) - 02:04, 7 July 2024
(Jan 2008). "Change in hemostatic markers after recombinant tissue-type plasminogen activator is not associated with the chance of recanalization". Stroke:...
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main achievement has been his role in the development of tissue-type plasminogen activator (t-PA) from a laboratory concept to a life-saving drug for...
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heart attack. Further thrombotic events could be treated with tissue plasminogen activator (tPA). Overdose of streptokinase or tPA can be treated with aminocaproic...
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Frostbite (redirect from Frostbite with tissue necrosis)
metaanalysis revealed that iloprost alone or iloprost plus recombinant tissue plasminogen activator (rtPA) may decrease amputation rate in case of severe frostbite...
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systemic fibrinolytic state and can lead to bleeding problems. Tissue plasminogen activator (tPA) is a different enzyme that promotes the degradation of...
21 KB (2,276 words) - 05:36, 25 June 2024
chemerin interleukin-6 (IL-6) monocyte chemotactic protein-1 (MCP-1) plasminogen activator inhibitor-1 (PAI-1) retinol binding protein 4 (RBP4) tumor necrosis...
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cancer. Gebbink MF (July 2011). "Tissue-type plasminogen activator-mediated plasminogen activation and contact activation, implications in and beyond haemostasis"...
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that promotes clot formation, while it increases levels of tissue type plasminogen activator, an enzyme that helps dissolve clots. These changes were estimated...
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(October 2002). "Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes: dependence on beta1...
17 KB (2,086 words) - 09:37, 10 March 2024