Uncompetitive inhibition (which Laidler and Bunting preferred to call anti-competitive inhibition, but this term has not been widely adopted) is a type...

non-competitive, or uncompetitive inhibitors. Many sources continue to conflate these two terms, or state the definition of allosteric inhibition as the definition...

competitive inhibition, in which the inhibitor can only bind the enzyme if the substrate has not already bound, and uncompetitive inhibition, in which the...

This can be competitive inhibition, uncompetitive inhibition, non-competitive inhibition or partially competitive inhibition. If the molecule induces...

increases with uncompetitive inhibition, or lowers the apparent value of K m {\displaystyle K_{\mathrm {m} }} . Graphically uncompetitive inhibition can be identified...

inhibitors may display competitive, non-competitive, or uncompetitive inhibition. In competitive inhibition, an inhibitor that resembles the normal substrate...

unchanged, and for uncompetitive (also called anticompetitive) inhibition the degree of inhibition increases with [S]. Reversible inhibition can be described...

to competitive inhibition, non-competitive inhibition cannot be overcome with high substrate concentration.: 76–78  An uncompetitive inhibitor cannot...

{ic} }} is the competitive inhibition constant and K i u {\displaystyle K_{\mathrm {iu} }} is the uncompetitive inhibition constant. This equation includes...

an antibiotic. Product inhibition can be competitive, non-competitive or uncompetitive. One method to reduce product inhibition is the use of a membrane...

inhibition, but it is not non-competitive inhibition as understood by Michaelis. The remaining important kind of inhibition, uncompetitive inhibition...

inhibitors. They work by modifying the immune system via cytokine activity inhibition. Cytokines play key roles in controlling cell growth and the immune response...

and reduces the maximal effect that can be produced by the agonist. Uncompetitive antagonists differ from non-competitive antagonists in that they require...

Ivosidenib showed uncompetitive inhibition to the NADP cofactor, showing a hyperbolic curve for the rate constant of inhibition relative to concentration...

an enzyme inhibitor. At low concentrations, bicarbonate shows uncompetitive inhibition, where it binds to the one of enzyme's anionic binding sites, and...

enhances the executive functions of self-motivation, sustained attention, inhibition, working memory, reaction time and emotional self-regulation. Use of atomoxetine...

mechanism for THC. Since 1989, memantine has been recognized to be an uncompetitive antagonist of the NMDA receptor, entering the channel of the receptor...

antagonists, if they compete with the main drug to bind with the receptor. or uncompetitive antagonists, when the antagonist binds to the receptor irreversibly...

noncompetitive antagonists inhibit binding to NMDARs allosteric sites; and uncompetitive antagonists block binding to a site within the ion channel. AP5 (APV...

PMID 22182754. Goldstein M, Anagnoste B, Lauber E, Mckeregham MR (July 1964). "Inhibition of dopamine- β -hydroxylase by disulfiram". Life Sciences. 3 (7): 763–7...

GAMEN loop without interacting with the zing atom, leading to uncompetitive inhibition, confirmed later on by kinetic studies. GRCh38: Ensembl release...

microbial flavohemoglobin, impair ferric heme reduction, produce uncompetitive inhibition with respect to O2 and NO, and inhibit NO metabolism by yeasts...

safer clinical option. However, dizocilpine is the most frequently used uncompetitive NMDA receptor antagonist in animal models to mimic psychosis for experimental...

uncompetitive antagonists. An uncompetitive antagonist is slightly different from the other two types of antagonists. The action of an uncompetitive antagonist...

(March 1990). "Distinctive structural requirement for the binding of uncompetitive blockers (phencyclidine-like drugs) to the NMDA receptor". European...

been found to possess the following actions (<1 μM) using rat tissues: Uncompetitive antagonist of the NMDA receptor via the MK-801/PCPTooltip phencyclidine...

monoamine transporters to produce monoamine reuptake inhibition. However, no functional inhibition (IC50) of the human monoamine transporters has been...

addition to fast-acting phasic inhibition, small amounts of extracellular GABA can induce slow timescale tonic inhibition on neurons. GABAA receptors are...

Traditionally reversible enzyme inhibitors have been classified as competitive, uncompetitive, or non-competitive, according to their effects on KM and Vmax. These...

μg/mL) and type 2 isoenzyme uncompetitively (Ki = 4.9 μg/mL) inhibited. In vitro studies revealed a 5a-reductase inhibition activity of 1:5600 compared...