VEGF receptors (VEGFRs) are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. Depending...

act as VEGF receptors. In mammals, the VEGF family comprises five members: VEGF-A, placenta growth factor (PGF), VEGF-B, VEGF-C and VEGF-D. The latter...

class II (Insulin receptor family) RTK class III (PDGF receptor family) RTK class IV (VEGF receptors family) RTK class V (FGF receptor family) RTK class...

domain receptor (KDR, a type IV receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor. KDR...

stimulated by VEGF: sunitinib, sorafenib, axitinib, and pazopanib (some of these therapies target VEGF receptors rather than the VEGFs). Both antibody-based...

characterized. VEGF-A shows prominent activity with vascular endothelial cells, primarily through its interactions with the VEGFR1 and -R2 receptors found prominently...

of VEGF-C is to promote the growth of lymphatic vessels (lymphangiogenesis). It acts on lymphatic endothelial cells (LECs) primarily via its receptor VEGFR-3...

factor receptor 1 is a protein that in humans is encoded by the FLT1 gene. FLT1 is a member of VEGF receptor gene family. It encodes a receptor tyrosine...

sclerosis. VEGF-B exerts its effects via the FLT1 receptor. But the role of co-receptor NRP in VEGF-B-mediated effects is still unclear. VEGF-B has also...

non-membrane associated splice variant of VEGF receptor 1 (Flt-1), sFlt-1 binds the angiogenic factors VEGF (vascular endothelial growth factor) and PlGF...

vascular endothelial growth factor (VEGF-A) which is a proangiogenic growth factor. These biological signals activate receptors on endothelial cells present...

kinase receptors include the insulin receptor, the IGF1 receptor, the MuSK protein receptor, the Vascular Endothelial Growth Factor (or VEGF) receptor, etc...

properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors". Oncogene. 9 (12): 3545–55. PMID 7970715. Fournier...

are VEGF-dependent, challenging the belief that VEGF's role in cancer is limited to angiogenesis. Instead, this research suggests that VEGF receptor-targeted...

proliferation, metastasis and angiogenesis. The VEGF receptor family contains three members, which are all receptor tyrosine kinases (VEGFR-1, VEGFR-2 and VEGFR-3)...

Blocks Vascular Endothelial Growth Factor (VEGF)-Mediated Vascular Hyperpermeability without Altering VEGF Receptor 2-Dependent Luteal Angiogenesis in a Rat...

"Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)". Proceedings of the National...

downregulated in cells with activated Notch signaling by lowering the levels of Vegf receptor transcript. Zebrafish embryos lacking Notch signaling exhibit ectopic...

kinase receptors include the insulin receptor, the IGF-1 receptor, the MuSK protein receptor, the vascular endothelial growth factor (VEGF) receptor, etc...

Jayakrishna (October 1, 2006). "Corneal avascularity is due to soluble VEGF receptor-1". Nature. 443 (7114): 993–997. Bibcode:2006Natur.443..993A. doi:10...

Recentin) is a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases. The drug is being developed by AstraZeneca as a possible...

including Src Homology 3 (SH3 domain), Vascular Endothelial Growth Factor (VEGF) receptor 2, and antibody Immunoglobulin G biomarkers for the identification of...

have not received prior therapy with bevacizumab or other VEGF inhibitors or VEGF receptor-targeted agents. In May 2020, the FDA expanded the indication...

The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase...

widely used VEGF pathway inhibitor on the market today is Bevacizumab. Bevacizumab binds to VEGF and inhibits it from binding to VEGF receptors. Angiogenesis...

Typically, the signaling process involves three components: the signal, the receptor, and the effector.[citation needed] In biology, signals are mostly chemical...

"Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)". Proc Natl Acad Sci U...

inhibitors (e.g. perifosine in a phase III trial) Apatinib is a selective VEGF Receptor 2 inhibitor which has shown encouraging anti-tumor activity in a broad...

M.; Baldwin, M. E. (2006). "Corneal avascularity is due to soluble VEGF receptor-1". Nature. 443 (7114): 993–997. Bibcode:2006Natur.443..993A. doi:10...

Schering and Novartis. It inhibits all known VEGF receptors, as well as platelet-derived growth factor receptor-beta and c-kit, but is most selective for...