Werner syndrome ATP-dependent helicase, also known as DNA helicase, RecQ-like type 3, is an enzyme that in humans is encoded by the WRN gene. WRN is a...

Werner syndrome (WS) or Werner's syndrome, also known as "adult progeria", is a rare, autosomal recessive disorder which is characterized by the appearance...

Sopher BL, Martin GM, et al. (September 1997). "The Werner syndrome protein is a DNA helicase". Nature Genetics. 17 (1): 100–103. doi:10.1038/ng0997-100...

DNA helicase family. Mutations in genes encoding other members of this family, namely WRN and RECQL4, are associated with the clinical entities Werner syndrome...

connected to Werner syndrome. WRN encodes the WRNp protein, a 1432 amino acid protein with a central domain resembling members of the RecQ helicases. WRNp is...

if not repaired. This is exemplified by the dependency of the Werner syndrome helicase in MSI-H cancers. Microsatellite instability is associated with...

disorder, Werner syndrome". Mutat. Res. 577 (1–2): 252–9. doi:10.1016/j.mrfmmm.2005.03.021. PMID 15916783. Monnat RJ (2010). "Human RECQ helicases: roles...

DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs...

helicases; thus it is crucial that RecQ is present and functional to ensure proper human growth and development.[citation needed] The Werner syndrome...

(mean lifespan 13 years).[citation needed] Werner syndrome is due to an inherited defect in an enzyme (a helicase and exonuclease) that acts in base excision...

other members of the RecQ helicase family. Two other genetic diseases are due to mutations in other RECQ helicases. Bloom syndrome is associated with mutations...

(February 2012). "Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease". Biogerontology. 13...

Bloom syndrome Cockayne syndrome Fanconi anemia Progeria (Hutchinson–Gilford progeria syndrome) Rothmund–Thomson syndrome Trichothiodystrophy Werner syndrome...

mutations in the DNA helicase RECQL4 gene, causing problems during initiation of DNA replication has been implicated in the syndrome. Sun-sensitive rash...

"Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): xeroderma pigmentosum without and with Cockayne syndrome". Human Mutation. 27 (11): 1092–103...

Andel RNJ, Oshima J, Madan K, Nieuwint AWM, Aalfs CM (2003) Atypical progeroid syndrome: an unknown helicase gene defect? Am J Med Genet 116A: 295-299...

Rothmund–Thomson syndrome Schizophrenia, associated with 8p21-22 locus Waardenburg syndrome Werner syndrome Pingelapese blindness Langer–Giedion syndrome Roberts...

similar to that of helicase with the Werner syndrome PRKAB2 is involved in maintaining the energy level of cells. With 1q21.1-deletion syndrome this function...

(melanoma differentiation-associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded by the IFIH1 gene in humans. MDA5 is part of the...

Probable ATP-dependent RNA helicase DDX11 is an enzyme that in humans is encoded by the DDX11 gene. DEAD box proteins, characterized by the conserved motif...

RNF4 has been shown to be responsible for the degradation of the Werner syndrome helicase in MSI-H cells after WRN inhibition. RING finger domain GRCh38:...

been shown to be responsible for the SUMOylation of inhibited Werner syndrome helicase (WRN) trapped on DNA in microsatellite unstable cancer cells. GRCh38:...

breast, and colon cancers. Werner's syndrome is a genetic disorder that causes premature aging. Patients with Werner's syndrome lack a functional WRN protein...

Telomerase reverse transcriptase, Tyrosine kinase 2, and Werner syndrome ATP-dependent helicase. GRCh38: Ensembl release 89: ENSG00000079246 – Ensembl,...

increased DNA breaks. The role of CHD1L is similar to that of helicase with the Werner syndrome GRCh38: Ensembl release 89: ENSG00000131778 – Ensembl, May...

isolated for this gene. WRNIP1 has been shown to interact with Werner syndrome ATP-dependent helicase. GRCh38: Ensembl release 89: ENSG00000124535 – Ensembl,...

role in Werner Syndrome, a premature aging disease that is associated with early onset of cancer. WRN helicase, which is mutated in Werner Syndrome patients...

cancer-related diseases Bloom syndrome, Werner syndrome and Rothmund–Thomson syndrome are caused by malfunctioning copies of RecQ helicase genes involved in the...

presenilin 2 genes linked to early-onset AD, the RecQ helicase gene (WRN) which causes Werner's Syndrome, the MAPT mutations which cause FTLD-tau type, and...

PMID 12403614. Selak N, Bachrati CZ, Shevelev I, et al. (2008). "The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest...