repair protein XRCC1, also known as X-ray repair cross-complementing protein 1, is a protein that in humans is encoded by the XRCC1 gene. XRCC1 is involved...

nearby base excision repair intermediates close. These intermediates include XRCC1 and APLF and they can be recruited directly or through the PBZ domain of...

stable complex with the DNA repair protein XRCC1. These proteins interact via their C-terminal BRCT domains. XRCC1 has no enzymatic activity but instead appears...

(FEN1) to remove overhanging flaps. This is followed by recruitment of XRCC1–LIG3 to the site for ligating the DNA ends, leading to an intact DNA. MMEJ...

several mammalian short-patch proteins, including pol β, DNA ligase III, XRCC1, and the kinase domain of PNKP. The recent discovery that the poly-A polymerase...

determined. DNA polymerase beta has been shown to interact with PNKP and XRCC1. POLA1 POLA2 GRCm38: Ensembl release 89: ENSMUSG00000031536 – Ensembl, May...

(polβ), and scaffolding proteins such as X-ray cross-complementing gene 1 (XRCC1). After repairing, the PAR chains are degraded via Poly(ADP-ribose) glycohydrolase...

repair likely employs the process of non-homologous end joining involving XRCC1 and PARP1 proteins that are expressed in Sertoli cells. Sertoli cells have...

Albanes, Demetrius (2003). "Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer amongmale smokers in...

(inherited) polymorphisms of the DNA repair genes ERCC1, ERCC2 (XPD) and XRCC1 increase the risk of glioma. This indicates that altered or deficient repair...

repair genes have frequently hypermethylated promoters; these genes are XRCC1, MLH3, PMS1, RAD51B, XRCC3, RAD54B, BRCA1, SHFM1, GEN1, FANCE, FAAP20, SPRTN...

theory of aging). Aprataxin has been shown to interact with: PARP1, P53, XRCC1, and XRCC4. GRCh38: Ensembl release 89: ENSG00000137074 – Ensembl, May 2017...

PES1 REV1; RFC1; TOPBP1; TP53BP1; XRCC1 Zhang X, Moréra S, Bates PA, et al. (November 1998). "Structure of an XRCC1 BRCT domain: a new protein-protein...

RFC2 RFC3 RFC4 RFC5 Ubiquitin C Werner syndrome ATP-dependent helicase XRCC1 Y box binding protein 1 Proteins interacting with PCNA via APIM include...

via translocation. DNA ligase I and Flap endonuclease 1 or the Ligase-III-XRCC1 complex seal the nicks to complete NER. The process of nucleotide excision...

the Okazaki fragments. DNA ligase 3: complexes with DNA repair protein XRCC1 to aid in sealing DNA during the process of nucleotide excision repair and...

PARP1 has been shown to interact with: APTX MYBL2 RELA P53 POLA1 POLA2 XRCC1 ZNF423 DNA damage theory of aging Maximum lifespan Olaparib – a PARP inhibitor...

MP, Bohr VA (2015). "Partial loss of the DNA repair scaffolding protein, Xrcc1, results in increased brain damage and reduced recovery from ischemic stroke...

interfere with DNA repair. APTX is recruited to DNA single-strand breaks by XRCC1 protein, where it functions as a nick sensor to scan the single-strand breaks...

The short patch repair pathway employs POLB (DNA polymerase beta), APE1, XRCC1, PARP1 with the addition of either the LIG1 or LIG3 genes. When an insertion...

sequences. PNKP has been shown to interact with DNA polymerase beta and XRCC1. The human gene encoding PNKP was observed to be mutated in patients with...

deficiencies. These include deficiencies in PALB2, FANCD2, RAD51, ATM, MRE11, p53, XRCC1 and LSD1. ARID1A, a chromatin modifier, is required for non-homologous end...

enzymological problems ranging from DNA repair proteins like AP endonuclease to XRCC1 BRCT in collaboration with Tomas Lindahl's group, PML (promyelocytic leukemia...

Q9UIA9 18399 XPOT HGNC:12826 O43592 18400 XPR1 HGNC:12827 Q9UBH6 18401 XRCC1 HGNC:12828 P18887 18402 XRCC2 HGNC:12829 O43543 18403 XRCC3 HGNC:12830 O43542...

microhomology-mediated end joining: FEN1, Ligase III, MRE11, NBS1, PARP1 and XRCC1. All six of these genes are up-regulated in one or more cancers. In humans...

shown to interact with MUTYH, Flap structure-specific endonuclease 1 and XRCC1. Deficiency of APEX1 causes accummulation of DNA damage leading to both...

development of schizophrenia. In particular, the base excision repair protein XRCC1 has been implicated. The most consistent finding in post-mortem examinations...

found that cadmium caused repression of three of the DNA repair genes: XRCC1 needed for base excision repair, OGG1 needed for base excision repair, and...

also inhibit PARP2, e.g. niraparib. PARP2 has been shown to interact with XRCC1. PARP2 also interacts with HPF1. PARP2 binds to and bridges blunt DNA ends...

OGG1 regulates. Oxoguanine glycosylase has been shown to interact with XRCC1 and PKC alpha. OGG1 may be associated with cancer risk in BRCA1 and BRCA2...