classification, a Z-type ligand refers to a ligand that accepts two electrons from the metal center. This is in contrast to X-type ligands, which form a bond...
9 KB (1,102 words) - 15:15, 23 February 2023
In coordination chemistry, a ligand is an ion or molecule with a functional group that binds to a central metal atom to form a coordination complex. The...
35 KB (3,307 words) - 12:53, 22 September 2024
classes of ligands are respectively given the symbols L, X, and Z. The method was published by Malcolm L. H. Green in 1995. X-type ligands are those that...
6 KB (734 words) - 09:09, 9 January 2024
Ligand field theory (LFT) describes the bonding, orbital arrangement, and other characteristics of coordination complexes. It represents an application...
13 KB (1,581 words) - 05:06, 18 June 2024
equations that reflect the binding of ligands to macromolecules, as a function of the ligand concentration. A ligand is "a substance that forms a complex...
30 KB (3,330 words) - 13:07, 4 October 2024
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. The etymology stems from...
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Ligand-gated ion channels (LICs, LGIC), also commonly referred to as ionotropic receptors, are a group of transmembrane ion-channel proteins which open...
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transformation. Redox non-innocent behavior of ligands is illustrated by nickel bis(stilbenedithiolate) ([Ni(S2C2Ph2)2]z). As all bis(1,2-dithiolene) complexes...
15 KB (1,728 words) - 12:20, 31 January 2024
Metal aquo complex (redirect from Water ligand)
complexes are coordination compounds containing metal ions with only water as a ligand. These complexes are the predominant species in aqueous solutions of many...
15 KB (1,551 words) - 19:45, 27 October 2024
Docking (molecular) (redirect from Ligand docking)
which predicts the preferred orientation of one molecule to a second when a ligand and a target are bound to each other to form a stable complex. Knowledge...
33 KB (3,935 words) - 01:22, 28 October 2024
polydentate (multiple bonded) ligand is a molecule or ion that bonds to the central atom through several of the ligand's atoms; ligands with 2, 3, 4 or even 6...
57 KB (5,553 words) - 04:29, 2 October 2024
A ligand binding assay (LBA) is an assay, or an analytic procedure, which relies on the binding of ligand molecules to receptors, antibodies or other...
33 KB (4,118 words) - 10:39, 17 October 2024
Drug design (redirect from Ligand design)
of protein-ligand complexes". Journal of Chemical Information and Modeling. 46 (1): 380–391. doi:10.1021/ci050283k. PMID 16426072. Deng Z, Chuaqui C,...
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PD-L1 (redirect from Programmed cell death 1 ligand 1)
Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by...
25 KB (3,052 words) - 15:34, 14 September 2024
equation for determining ligand bond number is as follows: LBN = L + X + Z Where L represents the number of neutral ligands adding two electrons to the...
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Nuclear receptor (redirect from Ligand-binding domain)
receptors often occurs in the presence of a ligand—a molecule that affects the receptor's behavior. Ligand binding to a nuclear receptor results in a conformational...
74 KB (6,683 words) - 09:55, 12 September 2024
are organophosphorus compounds most commonly used as bidentate phosphine ligands in inorganic and organometallic chemistry. They are identified by the presence...
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Cis–trans isomerism (redirect from Z-isomer)
metal atom, and X and Y are two different types of ligands.) In the cis isomer, the two Y ligands are adjacent to each other at 90°, as is true for the...
16 KB (1,739 words) - 01:08, 5 August 2024
RANKL (redirect from RANK Ligand)
Receptor activator of nuclear factor kappa-Β ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced...
28 KB (3,309 words) - 05:21, 5 August 2024
Trans-spanning ligands are bidentate ligands that can span opposite sites of a complex with square-planar geometry. A wide variety of ligands that chelate...
3 KB (393 words) - 22:51, 27 March 2024
Metal acetylacetonates (redirect from Acetylacetonate ligand)
3COCHCOCH− 3) and metal ions, usually transition metals. The bidentate ligand acetylacetonate is often abbreviated acac. Typically both oxygen atoms bind...
25 KB (2,762 words) - 21:04, 12 August 2024
Inverted ligand field theory (ILFT) describes a phenomenon in the bonding of coordination complexes where the lowest unoccupied molecular orbital is primarily...
26 KB (2,935 words) - 12:44, 22 September 2024
{\displaystyle {\ce {L + R <=> LR}}} where L, R, and LR represent ligand (drug), receptor, and ligand-receptor complex concentrations, respectively. This equation...
19 KB (2,225 words) - 21:08, 29 May 2024
directly to an enzyme's active site or the binding site of the endogenous ligand of a receptor are called orthosteric regulators or modulators. The site...
37 KB (4,422 words) - 05:12, 29 September 2024
therapeutics for the treatment of COVID-19. Guggulsterone is a broad-spectrum ligand of steroid hormone receptors, and is known to possess the following activities:...
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Asymmetric hydrogenation (section Ligand classes)
R.; Zhou, Z.; Chan, A. S. C. (2006). "A New Class of Versatile Chiral-Bridged Atropisomeric Diphosphine Ligands: Remarkably Efficient Ligand Syntheses...
64 KB (6,355 words) - 10:03, 21 August 2024
Sodium channel (redirect from Ligand gated sodium channels)
at Nodes of Ranvier in developing neurons. Ligand-gated sodium channels are activated by binding of a ligand instead of a change in membrane potential...
51 KB (5,600 words) - 16:44, 18 September 2024
mixed-ligand complexes of the type [MLx(OH)y]z+, where L is a ligand. The hydroxide ion often serves as a bridging ligand, donating one pair of electrons to each...
41 KB (4,891 words) - 13:03, 26 August 2024
1,5-Cyclooctadiene (redirect from Cod ligand)
diene is a useful precursor to other organic compounds and serves as a ligand in organometallic chemistry. It is a colorless liquid with a strong odor...
13 KB (1,002 words) - 14:43, 28 August 2024
Metal carbonyl (redirect from Carbonyl ligand)
carbonyls are coordination complexes of transition metals with carbon monoxide ligands. Metal carbonyls are useful in organic synthesis and as catalysts or catalyst...
70 KB (7,931 words) - 06:04, 29 May 2024