ALOX15 (also termed arachidonate 15-lipoxygenase, 15-lipoxygenase-1, 15-LO-1, 15-LOX-1) is, like other lipoxygenases, a seminal enzyme in the metabolism...
44 KB (5,728 words) - 20:51, 25 April 2024
unusual in that lymphocytes typically express little or no ALOX15. It is suggested that ALOX15 and/or ALOX15B, perhaps operating through one of its arachidonic...
6 KB (696 words) - 16:23, 14 October 2023
of 662–711 amino acids. Mammalian LOX genes contain 14 (ALOX5, ALOX12, ALOX15, ALOX15B) or 15 (ALOX12B, ALOXE3) exons with exon/intron boundaries at highly...
32 KB (3,886 words) - 03:28, 23 April 2024
similar fashions, 15-lipoxygenase (15-lipoxygenase 1, 15-LOX, 15-LOX1, or ALOX15) initiates the metabolism of arachidonic acid to 15-HpETE, 15-HETE, eoxins...
84 KB (9,646 words) - 03:37, 12 August 2024
(also see 5-Hydroxyeicosatetraenoic acid). The enzymes 15-lipoxygenase-1 (ALOX15) and 15-lipoxygenase-2 (ALOX15B). ALOX15B catalyzes the oxidation of arachidonic...
21 KB (1,900 words) - 21:15, 28 July 2024
deemed an ortholog of ALOX15 and is designated as Alox15. Human ALOX12 and ALOX15 along with rodent leukocyte-type Alox12 and Alox15 are commonly termed...
32 KB (3,928 words) - 09:06, 1 September 2023
11Z,14Z-eicosatetraenoic acid) with a) ALOX15 (or possibly ALOX15B) followed by ALOX5; b) ALOX5 followed by ALOX15 (or possibly ALOX15B); or c) ALOX5 followed...
66 KB (7,270 words) - 21:47, 16 May 2024
15-lipoxygenase-2 (15-LO-2 or 15-LOX-2), is distinguished from its related oxygenase, ALOX15 or 15-lipoxygenase-1. This gene encodes a member of the lipoxygenase family...
8 KB (1,036 words) - 02:50, 11 September 2022
HGNC:436 P20292 592 ALOX12 HGNC:429 P18054 593 ALOX12B HGNC:430 O75342 594 ALOX15 HGNC:433 P16050 595 ALOX15B HGNC:434 O15296 596 ALOXE3 HGNC:13743 Q9BYJ1...
277 KB (17 words) - 23:17, 27 April 2024
responsible for metabolizing PUFA to resolvins: 15-lipoxygenase-1 (i.e. ALOX15), possibly 15-lipoxygenase-2 (i.e. ALOX15B), 5-lipoxygenase (i.e. ALOX5)...
11 KB (1,310 words) - 21:54, 11 May 2024
leukotriene and 5-hydroxyicosatetraenoic acid metabolites and 15-lipoxygenase (ALOX15) to overproduce pro-inflammatory 15-hydroxyicosatetraenoic acid metabolites...
10 KB (1,152 words) - 00:20, 5 September 2023
15-oxo-eicosatetraenoic acid is an eicosanoid metabolite of arachidonic acid made my ALOX15; it has weak chemotactic activity for human monocytes (sees 15-Hydroxyeicosatetraenoic...
65 KB (7,370 words) - 06:10, 19 July 2024
the maresins, this class of mediators includes: the 15-lipoxygenase (i.e. ALOX15 and/or possibly ALOX15B)-derived lipoxin A4 and B4 metabolites of the omega...
15 KB (1,623 words) - 20:55, 4 April 2024
catalyzed by enzymes with 15-lipoxygenase activity which in humans includes ALOX15, ALOX12, aspirin-treated cyclooxygenase 2, and cytochrome P450s of the microsomal...
37 KB (4,357 words) - 04:19, 25 March 2024
distinction to the other three human lipoxygenases (ALOX5, ALOX12, and ALOX15), because they were initially defined as being highly or even exclusively...
20 KB (2,593 words) - 04:15, 27 February 2024
composed of two β-sheets of four β-strands each. ALOX12; ALOX12B; ALOX12P2; ALOX15; ALOX15B; ALOX5; ALOXE3; LIPC; LIPG; LOXHD1; LPL; PKD1; PKD1L1; PKD1L2;...
3 KB (295 words) - 21:27, 18 September 2021
globin (HBA1 or HBA2, NM_000517.1) cccca-----cccu—cuuccccaa lipoxygenase (ALOX15, NM_001140) -ccca----gcccacuuuuccccaa alpha(I)-collagen (COL1A1, NM_000088)...
3 KB (441 words) - 04:45, 2 June 2024
another pathway, ALOX5 may act in series with a second lipoxygenase enzyme, ALOX15, to metabolize AA to lipoxin A4 (LxA4) and LxB4 (see Specialized pro-resolving...
61 KB (7,553 words) - 16:29, 17 August 2024
987, 7 March 2018 RP Kristjansson et al., "A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis," Nature Genetics...
103 KB (12,457 words) - 23:46, 12 June 2024
metabolism is proposed to represent a pathway for 5(S)-HETE inactivation. ALOX15 to metabolize 5(S)-HETE to 5(S),15(S)-dihydroxy-eicosatetraenoate (5,15-diHETE)...
48 KB (6,107 words) - 06:42, 13 August 2024
(12(S)-HpETE or 12S-HpETE). Arachidonate 15-lipoxygenase-1 (15-LO-1, 15-LOX-1, ALOX15), which is expressed in far more tissues that ALOX12, metabolizes arachidonic...
63 KB (6,987 words) - 10:03, 27 March 2024
15S-diHETE probably by double oxygenation of AA by a 15-lipoxygenase (probably ALOX15) or serial metabolism by two enzymes. Linotrin-1 and linotrin-2 are among...
9 KB (1,095 words) - 20:02, 4 March 2024
activity may be responsible for blocking the formation of the hepoxilins. ALOX15 is responsible for metabolizing arachidonic acid to 14,15-HxA3 and 14,15-HxB3...
32 KB (3,972 words) - 20:16, 12 July 2024
regulation of the animals’ ability to survive in low-oxygen environments (ALOX15). In the Yosemite transect, no significant change in avian species abundance...
55 KB (6,520 words) - 13:25, 22 June 2024
15(S)-HpETE): Eoxin A4 Eoxin C4 Eoxin D4 Eoxin E4 A 15-lipoxygenase (i.e. ALOX15 or ALOX15B) metabolizes arachidonic acid to 15(S)-HpETE (see 15-Hydroxyicosatetraenoic...
16 KB (1,853 words) - 07:49, 28 May 2024
in treating these skin, lung, and, possibly, nasal reactions in humans. ALOX15 5-Hydroxyeicosanoid dehydrogenase 5-HETE OXER1 Powell WS, Rokach J (April...
34 KB (4,353 words) - 15:28, 26 February 2024
implicated in working together to signal for pain perception. 15-lipoxygenase 1 (ALOX15), while best known for converting the 20 carbon polyunsaturated fatty acid...
67 KB (7,848 words) - 01:42, 11 December 2023
Cells metabolize arachidonic acid with 15-lipoxygenase-1 (i.e., 15-LO-1, ALOX15) to form 15(S)-HpETE as a major product and 12(S)-hydroperoxy-5Z,8Z,10E...
67 KB (7,345 words) - 06:16, 13 August 2024
reduced to 9(S)-HODE. However, ALOX15B, similar to human 15-lipoxygenase-1 (ALOX15), metabolizes linoleic acid to 13(S)-HODE but not to 9(S)-HODEs. Like most...
29 KB (3,702 words) - 01:43, 11 December 2023