• Thumbnail for Autophagy
    Autophagy (or autophagocytosis; from the Greek αὐτόφαγος, autóphagos, meaning "self-devouring" and κύτος, kýtos, meaning "hollow") is the natural, conserved...
    78 KB (9,300 words) - 22:17, 25 November 2024
  • Look up autophagy in Wiktionary, the free dictionary. Autophagy is a process in cellular biology. Autophagy may also refer to: Autophagia, a mental disorder...
    341 bytes (74 words) - 00:04, 8 April 2022
  • Autophagy database(s) aim to provide a comprehensive list of autophagy-related genes and proteins, whether they are identified as orthologs or homologs...
    16 KB (2,109 words) - 15:04, 5 July 2024
  • Autophagy is a monthly peer-reviewed scientific journal covering all aspects of cell autophagy. It is published by Taylor & Francis and the editor-in-chief...
    2 KB (119 words) - 23:00, 25 April 2023
  • Thumbnail for Yoshinori Ohsumi
    born February 9, 1945) is a Japanese cell biologist specializing in autophagy, the process that cells use to destroy and recycle cellular components...
    11 KB (1,469 words) - 07:40, 4 October 2024
  • prevent autophagy, while others utilize autophagy elements for intracellular development or cellular splitting. Macro autophagy, micro autophagy, and chaperon-mediated...
    41 KB (5,252 words) - 05:01, 2 November 2024
  • autophagy, which specifically denotes the normal process of self-degradation by cells. While typically used only for this specific process, autophagy...
    14 KB (1,397 words) - 20:04, 22 November 2024
  • Thumbnail for Autophagy protein 5
    Autophagy protein 5 (ATG5) is a protein that, in humans, is encoded by the ATG5 gene located on chromosome 6. It is an E3 ubi autophagic cell death. ATG5...
    22 KB (2,808 words) - 09:48, 15 April 2024
  • Thumbnail for Chaperone-mediated autophagy
    Chaperone-mediated autophagy (CMA) refers to the chaperone-dependent selection of soluble cytosolic proteins that are then targeted to lysosomes and directly...
    31 KB (3,623 words) - 00:33, 22 June 2024
  • selective autophagy is a cellular process for the selective, ubiquitin-dependent degradation of chaperone-bound proteins in lysosomes. Autophagy (Greek:...
    11 KB (1,144 words) - 19:52, 3 May 2024
  • Thumbnail for Intracellular digestion
    molecules. Generally, autophagy includes three small branches, which are macroautophagy, microautophagy, and chaperone-mediated autophagy. Most organisms that...
    5 KB (540 words) - 14:49, 29 June 2018
  • Thumbnail for Lysosome
    endocytosis, while material from the inside of the cell is digested through autophagy. The sizes of the organelles vary greatly—the larger ones can be more...
    43 KB (4,709 words) - 13:50, 12 October 2024
  • Thumbnail for MAP1LC3B
    the MAP1LC3B gene. LC3 is a central protein in the autophagy pathway where it functions in autophagy substrate selection and autophagosome biogenesis....
    40 KB (1,799 words) - 22:23, 2 December 2023
  • Thumbnail for Reactive oxygen species
    newer line of study has connected ROS levels and autophagy. ROS can also induce cell death through autophagy, which is a self-catabolic process involving...
    70 KB (8,490 words) - 21:24, 24 November 2024
  • Thumbnail for Pathophysiology of Parkinson's disease
    Parkinson's Disease include protein aggregation in Lewy bodies, disruption of autophagy, changes in cell metabolism or mitochondrial function, neuroinflammation...
    19 KB (2,216 words) - 15:41, 28 March 2024
  • Thumbnail for MTOR
    cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. As a core component of mTORC2, mTOR also functions...
    119 KB (12,661 words) - 15:12, 8 November 2024
  • Thumbnail for Cell death
    organism of which the cells are part. Apoptosis or Type I cell-death, and autophagy or Type II cell-death are both forms of programmed cell death, while necrosis...
    16 KB (1,909 words) - 19:13, 26 September 2024
  • Thumbnail for AIM center
    The Autophagy, Inflammation and Metabolism Center or AIM Center is an NIH-funded Center of Biomedical Research Excellence focused on the study of autophagy...
    6 KB (535 words) - 23:19, 26 September 2023
  • Thumbnail for Autophagy-related protein 13
    Autophagy-related protein 13 also known as ATG13 is a protein that in humans is encoded by the KIAA0652 gene. ATG13 is an autophagy factor required for...
    7 KB (840 words) - 13:37, 18 January 2024
  • Thumbnail for AMBRA1
    (activating molecule in Beclin1-regulated autophagy) is a protein that is able to regulate cancer cells through autophagy. AMBRA1 is described as a mechanism...
    14 KB (1,490 words) - 22:00, 15 June 2024
  • Thumbnail for ULK1
    is an enzyme that in humans is encoded by the ULK1 gene. Unc-51-like autophagy-activating kinases 1 and 2 (ULK1/2) are two similar isoforms of an enzyme...
    17 KB (1,930 words) - 14:55, 11 August 2024
  • Thumbnail for Goldilocks and the Three Bears
    229–32 Martin, S J (August 2011). "Oncogene-induced autophagy and the Goldilocks principle". Autophagy. 7 (8): 922–3. doi:10.4161/auto.7.8.15821. hdl:2262/73233...
    16 KB (1,778 words) - 03:43, 14 November 2024
  • Thumbnail for ATG16L1
    Autophagy related 16 like 1 is a protein that in humans is encoded by the ATG16L1 gene. This protein is characterized as a subunit of the autophagy-related...
    16 KB (1,731 words) - 06:41, 27 September 2024
  • Thumbnail for BNIP3
    BNIP3 (section Autophagy)
    mitochondrial swelling and fission, and an increase in mitochondrial turnover via autophagy. Sequence similarity with Bcl-2 family members was not detected. Humans...
    21 KB (2,672 words) - 04:34, 2 November 2024
  • Thumbnail for Spermidine
    theorized to promote autophagy via the MAPK pathway by inhibiting phosphorylation of raf, or possibly by inhibiting cytosolic autophagy-related protein acetylation...
    17 KB (1,407 words) - 05:58, 29 October 2024
  • Thumbnail for BECN1
    encoded by the BECN1 gene. Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6)  and BEC-1 in the C. elegans nematode. This protein...
    13 KB (1,482 words) - 16:14, 15 March 2024
  • York. He is known for his discovery of genes controlling autophagy (cell self-eating), autophagy functions in central nervous system, molecular mechanism...
    22 KB (2,346 words) - 18:49, 2 August 2024
  • Thumbnail for Crohn's disease
    the disease. Proposed mechanisms for smoking's effects include impaired autophagy, direct toxicity to immune cells, and changes in the microbiome. Diet...
    70 KB (7,936 words) - 21:35, 20 November 2024
  • used in treatment for loss of function Chaperone-mediated autophagy, a selective type of autophagy MEAI or "Chaperon", a pharmaceutical drug used as a safer...
    1 KB (185 words) - 23:31, 22 August 2021
  • Thumbnail for ATG8
    ATG8 (section In autophagy)
    Autophagy-related protein 8 (Atg8) is a ubiquitin-like protein required for the formation of autophagosomal membranes. The transient conjugation of Atg8...
    18 KB (2,085 words) - 18:55, 25 April 2024