mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function...

is encoded by the MTOR gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases. mTOR links with other proteins...

The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence...

rapamycin. These drugs are considered the first generation inhibitors of mTOR. These other inhibitors include everolimus and temsirolimus. Compared with the...

3-kinase inhibitors (PI3K inhibitors) are a class of medical drugs that are mainly used to treat advanced cancers. They function by inhibiting one or more...

Sirolimus was shown to inhibit the progression of dermal Kaposi's sarcoma in patients with renal transplants. Other mTOR inhibitors, such as temsirolimus...

Lattanzi, Giovanna (November 2016). "Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders". British Journal...

Immunosuppression BK virus Behcet's Disease Discovery and development of mTOR inhibitors Treatment methods for preventing organ rejection Jennings DL (2020)...

molecules are called FTIs (or farnesyl-transferase inhibitors). As with mTOR inhibitors, many companies developed them to treat cancers, where they were unsuccessful...

and has also been used to demonstrate a potential application for mTOR inhibitors in the treatment of neuropathic pain. Takeuchi CS, Kim BG, Blazey CM...

Akt/PKB signaling pathway Discovery and development of mTOR inhibitors PI3K/AKT/mTOR pathway Akt inhibitor PTEN PDB: 3MV5​; Freeman-Cook KD, Autry C, Borzillo...

which was one of the first non-rapalog derived inhibitors of the mechanistic target of rapamycin (mTOR) subtypes mTORC1 and mTORC2. In animal studies...

PMID 29078414. Tian T, Li X, Zhang J (February 2019). "mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy". International Journal...

Akt/PKB signaling pathway Discovery and development of mTOR inhibitors PI3K/AKT/mTOR pathway Akt inhibitor This disambiguation page lists articles associated...

growth, proliferation, and survival. mTOR inhibitors lead to cell cycle arrest in the G1 phase and also inhibits tumor angiogenesis by reducing synthesis...

a calcineurin inhibitor and an anti-proliferative agent. Where calcineurin inhibitors or steroids are contraindicated, mTOR inhibitors are used. Immunosuppressive...

Lattanzi, Giovanna (November 2016). "Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders". British Journal...

(Isoquinolin-4-yl)-1H-Pyrazolo[3,4-d]Pyrimidine Derivatives as Dual PI3-K/mTOR Inhibitors". Current Drug Discovery Technologies. 16 (3): 297–306. doi:10...

malignant tumors. Thus angiogenesis inhibitors have been closely studied for possible cancer treatment. Angiogenesis inhibitors were once thought to have potential...

which acts as a dual inhibitor of the kinase enzymes phosphatidylinositol 3-kinase (PI3K) and mechanistic target of rapamycin (mTOR). It is in clinical...

mTOR inhibitors are effective at shrinking the size of lymphangioleiomyomatosis, and can lead to total resolution. Sirolimus is an mTOR inhibitor that...

immunodeficiency of T-cells. Immunosuppressive drug Discovery and development of mTOR inhibitors BK virus Interleukin-2 immunotherapy B cell deficiency T cell deficiency...

medications, tyrosine kinase inhibitors (TKIs) and mammalian target of rapamycin (mTOR) inhibitors are effective in inhibiting angiogenesis, blocking growth...

MEK inhibitors in cancer therapy". Biochim Biophys Acta. 1773 (8): 1248–55. doi:10.1016/j.bbamcr.2006.11.009. PMID 17194493. "ASCO: MEK Inhibitors—Alone...

shown that introducing competitive inhibitors of GSK-3 can increase glucose tolerance in diabetic mice. GSK-3 inhibitors may also have therapeutic effects...

mTOR Complex 2 (mTORC2) is an acutely rapamycin-insensitive protein complex formed by serine/threonine kinase mTOR that regulates cell proliferation and...

isoform-specific inhibitors. As of January 2019, three PI3K inhibitors are approved by the FDA for routine clinical use in humans: the PIK3CD inhibitor idelalisib...

Hedgehog pathway inhibitors, also sometimes called hedgehog inhibitors, are small molecules that inhibit the activity of a component of the Hedgehog signaling...

commonly seen side-effects with oral multikinase inhibitors. Temsirolimus' high level of specificity for mTOR likely contributes to the tolerability of temsirolimus...

Targeted therapy may include monoclonal antibodies, mTOR inhibitors, and signal transduction inhibitors which all act to target cancer cells specifically...