Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13.11.34) that in humans...

Arachidonate 5-lipoxygenase inhibitors are compounds that slow or stop the action of the arachidonate 5-lipoxygenase (5-lipoxygenase or 5-LOX) enzyme...

Arachidonate 5-lipoxygenase-activating protein also known as 5-lipoxygenase activating protein, or FLAP, is a protein that in humans is encoded by the...

are as follows: Arachidonate 5-lipoxygenase (ALOX5) (EC 1.13.11.34; InterPro: IPR001885), also termed 5-lipoxygenase, 5-LOX, and 5-LO. Major products:...

essential fatty acid eicosapentaenoic acid (EPA) by the enzyme arachidonate 5-lipoxygenase. Leukotrienes use lipid signaling to convey information to either...

medication which functions as a leukotriene-related enzyme inhibitor (arachidonate 5-lipoxygenase) or leukotriene receptor antagonist (cysteinyl leukotriene receptors)...

'peanut', although peanut oil does not contain any arachidonic acid. Arachidonate is the name of the derived carboxylate anion (conjugate base of the acid)...

13.11.31), also known as arachidonate 12-lipoxygenase, 12-lipoxygenase, 12S-Lipoxygenase, 12-LOX, and 12S-LOX is a lipoxygenase-type enzyme that in humans...

ALOX15 (also termed arachidonate 15-lipoxygenase, 15-lipoxygenase-1, 15-LO-1, 15-LOX-1) is, like other lipoxygenases, a seminal enzyme in the metabolism...

(AEA: C 22H 37NO 2; 20:4,n−6), or its linoleoyl analogues, are by a lipoxygenase action found to be competitive inhibitors of brain and immune cell FAAH...

agents which function as leukotriene-related enzyme inhibitors (arachidonate 5-lipoxygenase) or leukotriene receptor antagonists (cysteinyl leukotriene receptors)...

fatty acid found primarily in seed oils. When acting on GLA, arachidonate 5-lipoxygenase produces no leukotrienes and the conversion by the enzyme of...

in urine. Mean elimination half-life (half-life) of montelukast is 2.7 to 5.5 hours in healthy young adults. "Montelukast Sodium Monograph for Professionals"...

co-localization of cytosolic phospholipase A2 (cPLA2), arachidonate 5-lipoxygenase (5-LO), 5-lipoxygenase-activating protein (FLAP) and LTC4 synthase (LTC4S)...

Zileuton (trade name Zyflo) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, used...

first mechanism involves a chain extension reaction by cinnamic acid and 5 malonyl-CoA molecules that eventually arylize into a curcuminoid. The second...

most commonly prescribed medication in the United States, with more than 5 million prescriptions. Azelastine nasal spray is indicated for the local treatment...

Analogue-based Drug Discovery. John Wiley & Sons. p. 467. ISBN 978-3-527-60749-5. "Captopril: Uses, Dosage, Side Effects". Drugs.com. Retrieved 2021-10-31...

ISBN 92-4-157119-5. ISSN 0250-863X. 1991 Piscitelli SC, Rodvold K (2005). Drug Interactions in Infectious Diseases. Humana Press. ISBN 978-1-58829-455-5. Drugs...

medication in the same class (e.g. montelukast) or in the related class of 5-lipoxygenase inhibitors can be attempted, but caution should be employed. According...

arachidonate-5-lipoxygenase, 5-lipoxygenase, 5-LO, and 5-LOX). ALOX5 metabolizes arachidonic acid to its hydroperoxide derivative, arachidonic acid 5-hydroperoxide...

metabolites of arachidonate 5-lipoxygenase (5-LOX): 5-hydroxyeicosatetraenoic acid (5-(S)-HETE), and its 5-keto analog 5-oxo-eicosatetraenoic acid (5-oxo-ETE)...

metabolized to the 3 double bond-containing analog of 5-HETE viz., 5-HETrE (see Arachidonate 5-lipoxygenase § Mead acid). Hydroxyeicosatetraenoic acids, leukotrienes...

inflammation, lipoxin A4 and lipoxin B4. Haeggström JZ, Funk CD (2011). "Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease"...

bitter and acrid. The flowers are conspicuous and showy, measuring about 1.5–2.5 cm across, and are bright yellow with black dots along the edges of the...

receptors. The flavonoid has been shown to inhibit certain types of lipoxygenases. Baicalein is an inhibitor of CYP2C9, an enzyme of the cytochrome P450...

(2006). Biochemistry (6th ed.). San Francisco: W. H. Freeman. ISBN 0-7167-8724-5.[page needed] Erion DM, Shulman GI (2010). "Diacylglycerol-mediated insulin...

extracts. Their reactions with amino acids and peptides". Biochem. J. 112 (5): 609–616. doi:10.1042/bj1120609. PMC 1187763. PMID 4980678. Cilliers, Johannes...

It may perform this by blocking the 5-lipoxygenase activating protein (FLAP), thus inhibiting 5-lipoxygenase (5-LOX), and may help in treating atherosclerosis...

Leukotriene A4 synthase may refer to: Arachidonate 5-lipoxygenase, an enzyme Arachidonate 12-lipoxygenase, an enzyme This set index page lists enzyme...