mTORC1, also known as mammalian target of rapamycin complex 1 or mechanistic target of rapamycin complex 1, is a protein complex that functions as a...

complex 1 (mTORC1) signaling pathway by binding to and modulating sestrin2, a leucine amino acid sensor and upstream regulatory pathway. The mTORC1 pathway...

his lab discovered the mTORC1 and mTORC2 multi-protein complexes, the nutrient sensing Rag GTPase pathway upstream of mTORC1, as well as the direct amino...

and proliferation by forming and signaling through two protein complexes, mTORC1 and mTORC2. The most established mTOR inhibitors are so-called rapalogs...

proliferation. RHEB localizes at the lysosome to activate mTORC1 and Rag7 proteins localize mTORC1 to the lysosome and the Ragulator-Rag complex, allowing...

mTOR is the catalytic subunit of two structurally distinct complexes: mTORC1 and mTORC2. The two complexes localize to different subcellular compartments...

and Rag C/Rag D. These interact to form heterodimers with one another. mTORC1 is a complex within the lysosome membrane that initiates growth when promoted...

up-regulation of the mammalian/mechanistic target of rapamycin complex 1 (mTORC1), a signaling cascade involved in coordination of translation initiation...

mTORC1 protein complex, with little impact on the mTORC2 complex. This can lead to a hyper-activation of the kinase AKT via inhibition on the mTORC1 negative...

triphosphatase (v-ATPase) interact with mTORC1 in response to amino acids from the lysosomal lumen to promote translocation of mTORC1 to the lysosomal surface for...

Vps34 is necessary for mTORC1 activity in response to amino acids in cultured cells, as siRNA knockdown completely inhibits mTORC1 signaling as determined...

a leucine sensor which stimulates mTORC1 in the presence of leucine. BC-LI-0186 blocks the docking site for mTORC1 and thereby prevents the mTOR activation...

growth. A key promoter of cell growth, mTORC1, is inhibited by the tuberous sclerosis complex. Insulin activates mTORC1 and causes dissociation of TSC from...

endogenous activator of the mechanistic target of rapamycin (mTOR) subtype mTORC1. Since many of the side effects of rapamycin and its analogues are thought...

metabolism, which is responsible for cell proliferation, can be regulated by mTORC1 signaling. In addition, intake of nutrients in animals can induce circulating...

also demonstrated that cellular bicarbonate metabolism can be regulated by mTORC1 signaling. Additionally, bicarbonate plays a key role in the digestive system...

inhibitor of both subtypes of the mechanistic target of rapamycin (mTOR), mTORC1 and mTORC2. It is being researched for the treatment of various forms of...

molecule inhibitor of mTOR which is administered orally. It targets both mTORC1 and mTORC2. Developed by Millennium Pharmaceuticals, and is in phase II...

also demonstrated that cellular bicarbonate metabolism can be regulated by mTORC1 signaling. The liver is the major organ of de novo synthesis of all four...

inhibitor of both subtypes of the mechanistic target of rapamycin (mTOR), mTORC1 and mTORC2. It is being researched for potential applications in the treatment...

which is found in 2 complexes in cells: mTOR complex 1 and 2 (mTORC1 and mTORC2). mTORC1 is activated through the T cell receptor (TCR) and the costimulatory...

active, mTORC1 inhibits autophagy by phosphorylating both ULK1 and ATG13, which reduces the kinase activity of ULK1. Under starvation conditions, mTORC1 is...

and subsequent activation of mTORC1, which leads to protein biosynthesis in cellular ribosomes via phosphorylation of mTORC1's immediate targets (the p70S6...

rapamycin, the dissection of its target in the mTORC1 signaling cascade, and the characterization of mTORC1 roles in cell fitness and growth control. Simultaneously...

treatment of interleukin-18 activated cells triggers the mTORC1 metabolic sensor, which indicates that mTORC1 causes amino acid-driven activation due to a high...

complex which negatively regulates mechanistic target of rapamycin complex 1 (mTORC1) signaling. C12orf66 is located on the minus strand in the locus 12q14.2...

including the activation of mechanistic target of rapamycin complex 1 (mTORC1) and inhibition of proteasome-mediated proteolysis in skeletal muscles....

inhibitor of the glucose transporters and also a selective inhibitor of mTORC1, with no significant action at the related mTORC2 subtype. Compounds of...

prophylaxis following a kidney transplant: While sirolimus inhibition of mTORC1 appears to mediate the drug's benefits, it also inhibits mTORC2, which results...

and regulates a different signaling pathway from mTORC1. Hall also identified many roles of mTORC1 and mTORC2, including ribosomes physically interact...