interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA at first non-coding RNA molecules...
56 KB (6,826 words) - 21:39, 26 August 2024
ribonucleic acid (RNA) molecules, microRNA (miRNA) and small interfering RNA (siRNA), are central to components to the RNAi pathway. Once mRNA is degraded,...
141 KB (15,474 words) - 08:09, 11 August 2024
interfering RNA (siRNA) and micro RNA (miRNA) to prevent mRNA translation and/or degrade mRNA. However, RNA aptamers are short, single stranded RNA molecules...
77 KB (8,886 words) - 09:03, 10 June 2024
transfer RNA (tRNA), microRNA (miRNA), small interfering RNA (siRNA), small nucleolar RNA (snoRNAs), Piwi-interacting RNA (piRNA), tRNA-derived small RNA (tsRNA)...
65 KB (7,606 words) - 20:16, 12 August 2024
levels. Using single-stranded RNA (ssRNA) fragments, such as microRNA (miRNA), or double-stranded small interfering RNA (siRNA), the complex functions as...
36 KB (3,836 words) - 14:30, 19 April 2024
the RNA-induced silencing complex or RISC. This complex contains an endonuclease that cleaves perfectly complementary messages to which the siRNA binds...
49 KB (5,922 words) - 14:24, 18 August 2024
Transfection (redirect from RNA transfection)
trans- and infection. Genetic material (such as supercoiled plasmid DNA or siRNA constructs), may be transfected. Transfection of animal cells typically...
34 KB (4,151 words) - 15:41, 22 June 2024
"Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing". RNA. 10 (3): 544–50. doi:10.1261/rna.5235104. PMC 1370948. PMID 14970398....
147 KB (16,689 words) - 03:41, 2 September 2024
Trans-acting siRNA (abbreviated "ta-siRNA" or "tasiRNA") are a class of small interfering RNA (siRNA) that repress gene expression through post-transcriptional...
9 KB (1,153 words) - 05:22, 31 January 2024
Cell-penetrating peptide (section siRNA delivery)
of siRNA to target luciferase or eGFP mRNA reporters. In another study, TAT-siRNA conjugate through a stable thiomaleimide linkage at 3'-end of siRNA was...
58 KB (7,214 words) - 11:04, 14 May 2024
ncRNAs from small non-coding RNAs, such as microRNAs (miRNAs), small interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs)...
115 KB (12,353 words) - 08:50, 7 August 2024
of small RNA have currently been identified, namely: small interfering RNA (siRNA), microRNA (miRNA), and piwi-interacting RNA (piRNA). siRNAs act in the...
47 KB (5,449 words) - 00:50, 6 August 2024
Telomerase (section Small interfering RNA (siRNA))
slower telomere shortening. siRNAs are small RNA molecules that induce the sequence-specific degradation of other RNAs. siRNA treatment can function similar...
49 KB (5,644 words) - 06:05, 27 April 2024
Gene silencing (category RNA)
RNAs (siRNA) and microRNA (miRNA), are approximately 21–23 nucleotides in length. The fragments integrate into a multi-subunit protein called the RNA-induced...
48 KB (5,609 words) - 16:25, 22 May 2024
RNAs such as microRNAs, siRNAs, piRNAs, snoRNAs, snRNAs, exRNAs, scaRNAs and the long ncRNAs such as Xist and HOTAIR. The number of non-coding RNAs within...
68 KB (7,253 words) - 04:01, 23 June 2024
about dsRNA. They form the genetic material of some viruses (double-stranded RNA viruses). dsRNA, such as viral RNA or siRNA, can trigger RNA interference...
8 KB (961 words) - 09:49, 18 June 2024
Piwi (section Role in RNA interference)
small interfering RNA (siRNA) generated from exogenous double-stranded RNA and microRNA (miRNA) generated from endogenous non-coding RNA, both produced by...
17 KB (1,948 words) - 22:39, 1 July 2024
Iran Small interfering RNA (siRNA) Syrna, also spelled Sirna, Greek village Syrna (island), also spelled Sirna, Greek island Sirna Therapeutics This disambiguation...
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esiRNA or Endoribonuclease-prepared siRNAs are a mixture of siRNA oligos resulting from cleavage of long double-stranded RNA (dsRNA) with an endoribonuclease...
6 KB (663 words) - 13:49, 4 June 2023
"New insights into siRNA amplification and RNAi". RNA Biology. 9 (8): 1045–1049. doi:10.4161/rna.21246. PMC 3551858. PMID 22858672. RNA+Replicase at the...
27 KB (3,099 words) - 15:01, 25 June 2024
for the different types of RNA are listed and explained. List of cis-regulatory RNA elements RNA: Types of RNA Non-coding RNA Gribaldo S, Brochier-Armanet...
20 KB (1,022 words) - 13:20, 22 February 2024
interference in human disease therapy. Sirna's development pipeline included several small interfering RNA (siRNA) drugs, thought to stably silence the...
4 KB (426 words) - 04:09, 16 December 2020
Dicer (category RNA interference)
miRNA. Small interfering RNA (siRNA) are produced and function in a similar manner to miRNA by cleaving double-stranded RNA with Dicer into smaller fragments...
25 KB (3,219 words) - 05:09, 24 July 2024
promoters. RNA polymerase III synthesizes tRNAs, rRNA 5S and other small RNAs found in the nucleus and cytosol. RNA polymerase IV synthesizes siRNA in plants...
41 KB (4,799 words) - 19:34, 17 April 2024
Gene knockdown (section RNA interference)
mRNA transcript (e.g. by small interfering RNA (siRNA)) or RNase-H dependent antisense, or through the blocking of either mRNA translation, pre-mRNA splicing...
13 KB (1,611 words) - 09:30, 4 May 2023
Inclisiran (category Small interfering RNA)
heterozygous familial hypercholesterolemia (HeFH). It is a small interfering RNA (siRNA) that acts as an inhibitor of a proprotein convertase, specifically, inhibiting...
21 KB (1,744 words) - 14:15, 24 April 2024
the siRNA drug Onpattro. LNPs became more widely known in late 2020, as some COVID-19 vaccines that use RNA vaccine technology coat the fragile mRNA strands...
23 KB (2,629 words) - 15:37, 19 March 2024
RDE-1 (category RNA interference)
exogenous trigger dsRNA is bound by RDE-4 and cleaved into 21-25nt primary siRNA by a Dicer complex that includes RDE-1. Primary siRNA binding to RDE-1 then...
8 KB (941 words) - 11:41, 13 August 2023
how piRNAs are generated, but potential methods had been suggested, and it was certain their biogenesis pathway is distinct from miRNA and siRNA, while...
44 KB (5,235 words) - 10:51, 22 February 2024
MRNA vaccine (redirect from Rna vaccine)
the first siRNA drug, Onpattro. Encapsulating the mRNA molecule in lipid nanoparticles was a critical breakthrough for producing viable mRNA vaccines,...
77 KB (7,879 words) - 16:49, 14 July 2024