Serine/threonine kinase 11 (STK11) also known as liver kinase B1 (LKB1) or renal carcinoma antigen NY-REN-19 is a protein kinase that in humans is encoded...

That residue is phosphorylated by at least three kinases (liver kinase B1 (LKB1), which works in a complex with STRAD and MO25, Calcium/calmodulin-dependent...

Biology. She is best known for her research on the tumor suppressor kinase LKB1, and its role in regulating the chromatin remodeling protein SMARCA4 and...

kinase and tumor suppressing Lkb1. In 2005, his lab showed that the type 2 diabetes drug Metformin operates by targeting both Lkb1 and AMP-activated protein...

associated with the mutation. On chromosome 19, the gene known as STK11 (LKB1) is a possible tumor suppressor gene. It is inherited in an autosomal dominant...

kinase LKB1 coactivates ERα in the cell nucleus through direct binding, in which it is recruited to the promoter of ERα-responsive genes. LKB1 catalytic...

experimental observations suggest that microRNA-451 is a key regulator of LKB1/AMPK signaling in cultured glioma cells and that miRNA clustering controls...

also denotes the gene encoding it. Endogenous LKB1 and STRADα form a complex in which STRADα activates LKB1, resulting in phosphorylation of both partners...

interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm". EMBO J. 22 (19): 5102–14. doi:10.1093/emboj/cdg490. PMC 204473...

changes. Both LKB1 and AMPK are serine/threonine kinases acting predominantly opposingly to the aforementioned molecules. From the two, LKB1's activation...

Lo AK, Lo KW, Ko CW, Young LS, Dawson CW (July 2013). "Inhibition of the LKB1-AMPK pathway by the Epstein-Barr virus-encoded LMP1 promotes proliferation...

activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways". Cancer Research. 66 (1): 315–23...

respond to the presence of reactive oxygen species (ROS) while HIF1A and LKB1 respond to hypoxic conditions. In hematopoietic stem cells, autophagy is...

FGF21 on mitochondrial function require serine/threonine kinase 11 (STK11/LKB1), which activates AMPK. Inhibition of AMPK, SIRT1, and PGC-1α activities...

Is an Agonistic Ligand for PPARα and Improves NASH by Activation of SIRT1/LKB1/pAMPK". Hepatology Communications. 4 (3): 434–449. doi:10.1002/hep4.1474...

recruit its substrates without Raptor, no protein synthesis via mTORC1 occurs. LKB1, also known as STK11, is a known tumor suppressor that can activate AMPK...

phosphorylate and activate the AMP-activated protein kinase. Fairly recently, LKB1 has been identified as a likely AMP kinase kinase, which appears to involve...

LKB1/NUAK1 signalling pathway regulates terminal axon branching at cortical neurons, via local immobilized mitochondria capture. Besides NUAK1, LKB1 kinase...

Nagaraju, Ganji Purnachandra; Vadde, Ramakrishna (eds.), "Chapter 22 - LKB1/STK11-mediated signal transduction in hepatocellular carcinoma", Theranostics...

T, Moeslein G, Launonen V, Tomlinson IP, Silver AR, Aaltonen LA (2006). "LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome"...

serves as an endosomal docking site for LKB1-mediated AMPK activation by forming the v-ATPase-Ragulator-AXIN/LKB1-AMPK complex. This allows a switch between...

involved in tumor progression. Sox2 overexpression cooperates with loss of Lkb1 expression to promote squamous cell lung cancer in mice. Its overexpression...

reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss". Oncotarget. 5 (24): 12738–12752. doi:10.18632/oncotarget.2818. ISSN 1949-2553...

activating the serine/threonine kinase LKB1 located in the basal body of resting cells in response to flow stimuli. LKB1 in turn phosphorylates and activates...

Al-Hakim AK, Göransson O, Deak M, et al. (2006). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK". J. Cell Sci. 118...

Sanchez-Verde L, Sanchez-Cespedes M (September 2007). "Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal...

Udd L, Mäkelä TP, Alessi DR, Hardie DG (Jul 2004). "Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases...

Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR (Feb 2004). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including...

A; Pearson, HB; Winton, DJ; Sansom, OJ; Ashworth, A; Clarke, AR (2009). "Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine"...

protein kinase STRADα regulates activity of the conventional protein kinase, LKB1 JAK1-3 and TYK2 C-terminal tyrosine kinase domains are regulated by their...