The T-cell receptor (TCR) is a protein complex found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen...
43 KB (5,372 words) - 15:31, 6 August 2024
chimeric antigen receptors (CARs)—also known as chimeric immunoreceptors, chimeric T cell receptors or artificial T cell receptors—are receptor proteins that...
83 KB (8,682 words) - 13:12, 22 October 2024
of a T-cell receptor (TCR) on their cell surface. T cells are born from hematopoietic stem cells, found in the bone marrow. Developing T cells then migrate...
71 KB (9,026 words) - 03:44, 25 October 2024
T cell receptor T cell therapy (TCR-T) is a type of adoptive T-cell therapy that targets some cancers. TCR-T therapies use heterodimers made of alpha and...
5 KB (632 words) - 04:12, 5 August 2024
Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the plasma membrane of cells. They act in cell...
21 KB (2,456 words) - 22:14, 21 November 2023
The B-cell receptor (BCR) is a transmembrane protein on the surface of a B cell. A B-cell receptor is composed of a membrane-bound immunoglobulin molecule...
18 KB (2,173 words) - 16:05, 30 November 2023
Gamma delta T cells (γδ T cells) are T cells that have a γδ T-cell receptor (TCR) on their surface. Most T cells are αβ (alpha beta) T cells with TCR composed...
35 KB (4,472 words) - 00:20, 13 June 2024
T-cell receptor excision circles (TRECs) are small circles of DNA created in T-cells during their passage through the thymus as they rearrange their TCR...
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Thymocyte (redirect from T cell selection)
cell which expresses them, the T cell receptor is made up of a series of alternative gene fragments. In order to create a functional T cell receptor,...
21 KB (2,589 words) - 10:38, 12 August 2024
bacteria), or cells that are damaged in other ways. Most cytotoxic T cells express T-cell receptors (TCRs) that can recognize a specific antigen. An antigen is...
31 KB (3,843 words) - 10:18, 12 August 2024
memory T cells expressing a specific T cell receptor can persist for decades in our body. Since memory T cells have shorter half-lives than naïve T cells do...
32 KB (3,781 words) - 12:49, 26 April 2024
Complement Receptor 1 and 2 (CR1, CR2) and the production of interleukin 8 (IL-8). Like all T cells, they express the T cell receptor-CD3 complex. The T cell receptor...
54 KB (6,597 words) - 14:51, 21 July 2024
express functional IL-7 receptors, consisting of subunits IL-7 receptor-α, CD127, and common-γ chain, CD132. In the naive state, T cells are thought to require...
9 KB (1,142 words) - 13:25, 25 October 2024
CD1d-restricted T cells, present in mice and humans, some of which coexpress a heavily biased, semi-invariant T-cell receptor and NK cell markers. NKT cells are a...
14 KB (1,648 words) - 09:58, 18 July 2023
T-cell receptor revision (alternative term: antigen receptor editing) is a process in the peripheral immune system which is used by mature T cells to alter...
11 KB (1,333 words) - 15:19, 23 February 2024
transcript. J.RT3-T3.5 cells have a mutation in the T cell receptor beta chain locus precluding expression of this chain. This affects the cells in several ways;...
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Tcr-seq (section T-cell Receptor (TCR))
(T-cell Receptor Sequencing) is a method used to identify and track specific T cells and their clones. TCR-Seq utilizes the unique nature of a T-cell receptor...
22 KB (2,554 words) - 14:34, 22 July 2024
thymus. All T cells begin as CD4-CD8-TCR- cells at the DN (double-negative) stage, where an individual cell will rearrange its T cell receptor genes to form...
79 KB (9,481 words) - 19:49, 18 October 2024
messengers which bind to a receptor and produce physiological responses such as change in the electrical activity of a cell. For example, GABA, an inhibitory...
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CD3 (immunology) (redirect from CD3 receptor)
complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is...
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Antigen (redirect from Receptors, antigen)
allergen, such as pollen, that can bind to a specific antibody or T-cell receptor. The presence of antigens in the body may trigger an immune response...
20 KB (2,435 words) - 20:51, 22 October 2024
inhibitory receptors. Most immune cells detect the antigen presented on major histocompatibility complex I (MHC-I) on infected cell surfaces, but NK cells can...
75 KB (9,227 words) - 23:32, 16 October 2024
Stevens–Johnson syndrome (section T-cell receptors)
antigen (i.e. HLA) serotypes (i.e. genetic alleles), genetical-based T cell receptors, or variations in their efficiency to absorb, distribute to tissues...
56 KB (5,844 words) - 03:24, 2 September 2024
presentation. T cells may recognize these complexes using their T cell receptors (TCRs). APCs process antigens and present them to T cells. Almost all cell types...
16 KB (2,128 words) - 09:55, 4 March 2024
syndrome by interacting with a T-cell receptor is limited to those individuals whose T cells express a T-cell receptor(s) that can interact with drug...
38 KB (4,291 words) - 18:22, 3 September 2024
Superantigen (section T-cell receptor)
(Vβ region) of the T-cell Receptor. A given SAg can activate a large proportion of the T-cell population because the human T-cell repertoire comprises...
28 KB (3,559 words) - 21:41, 13 July 2024
Cancer immunotherapy (redirect from Adoptive T-cell therapy)
fact that cancer cells often have tumor antigens, molecules on their surface that can bind to antibody proteins or T-cell receptors, triggering an immune...
92 KB (12,517 words) - 05:38, 1 October 2024
PD-1 is a cell surface receptor on T cells and B cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating...
39 KB (5,010 words) - 05:27, 17 August 2024
for activation of T cells, also known as linker of activated T cells or LAT, is a protein involved in the T-cell antigen receptor signal transduction...
19 KB (2,288 words) - 20:03, 3 April 2024
T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 (Cluster of Differentiation 247) is a protein that in humans...
5 KB (615 words) - 20:53, 3 March 2023