Ubiquitin is a small (8.6 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e., it is found ubiquitously. It was discovered in...
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A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin...
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Proteasome (redirect from Ubiquitin proteosome system)
Proteasomes are protein complexes which degrade ubiquitin-tagged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that...
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encoded by the UBC gene in humans. Polyubiquitin-C is one of the sources of ubiquitin, along with UBB, UBA52, and RPS27A. UBC gene is one of the two stress-regulated...
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Ubiquitin is a protein that in humans is encoded by the UBB gene. Ubiquitin is one of the most conserved proteins known in eukaryotic organisms. Ubiquitin...
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Ubiquitin D is a protein that in humans is encoded by the UBD gene, also known as FAT10. UBD acts like ubiquitin, by covalently modifying proteins and...
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Ubiquitin-activating enzymes, also known as E1 enzymes, catalyze the first step in the ubiquitination reaction, which (among other things) can target...
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Ubiquitin-binding domains (UBDs) are protein domains that recognise and bind non-covalently to ubiquitin through protein-protein interactions. As of 2019...
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LUBAC (redirect from Linear ubiquitin chain assembly complex)
Linear ubiquitin chain assembly complex (LUBAC) is a multi-protein complex and the only known E3 ubiquitin ligase able to conjugate ubiquitin in a head-to-tail...
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UBA protein domain (redirect from Ubiquitin-associated domain)
Ubiquitin-associated (UBA) domains are protein domains that non-covalently interact with ubiquitin through protein-protein interactions. Ubiquitin is a...
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In molecular biology, the Ubiquitin-Interacting Motif (UIM), or 'LALAL-motif', is a sequence motif of about 20 amino acid residues, which was first described...
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SCF complex (redirect from SCF ubiquitin ligase complex)
Cullin, F-box containing complex (or SCF complex) is a multi-protein E3 ubiquitin ligase complex that catalyzes the ubiquitination of proteins destined...
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HERC2 (redirect from E3 ubiquitin ligase HERC2)
HERC2 is a giant E3 ubiquitin protein ligase, implicated in DNA repair regulation, pigmentation and neurological disorders. It is encoded by a gene of...
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enzymology, an ubiquitin-calmodulin ligase (EC 6.3.2.21) is an enzyme that catalyzes the chemical reaction n ATP + calmodulin + n ubiquitin ⇌ {\displaystyle...
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Ubiquitin-conjugating enzymes, also known as E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step in the ubiquitination reaction...
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SUMO protein (redirect from Small ubiquitin-like modifier)
In molecular biology, SUMO (Small Ubiquitin-like Modifier) proteins are a family of small proteins that are covalently attached to and detached from other...
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Ubiquitin carboxy-terminal hydrolase L1 (EC 3.1.2.15, ubiquitin C-terminal hydrolase, UCH-L1) is a deubiquitinating enzyme. UCH-L1 is a member of a gene...
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Endoplasmic-reticulum-associated protein degradation (section Ubiquitin-dependent degradation by the proteasome)
degradation by facilitating binding of ERAD lectins OS9 and XTP3-B. Because the ubiquitin–proteasome system (UPS) is located in the cytosol, terminally misfolded...
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DTX3L (redirect from Deltex e3 ubiquitin ligase 3l)
Deltex E3 ubiquitin ligase 3L is a protein that in humans is encoded by the DTX3L gene. It functions as an ubiquitin ligase (E3), and is over-expressed...
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Ubiquitinyl hydrolase 1 (redirect from Yeast ubiquitin hydrolase)
Ubiquitinyl hydrolase 1 (EC 3.4.19.12, ubiquitin C-terminal hydrolase, yeast ubiquitin hydrolase) is an enzyme. This enzyme catalyses the following chemical...
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Ubiquitin-like proteins (UBLs) are a family of small proteins involved in post-translational modification of other proteins in a cell, usually with a...
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UBE3A (redirect from Ubiquitin protein ligase E3A)
Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the UBE3A gene. This...
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Ubiquitin-specific-processing protease 7 (USP7), also known as ubiquitin carboxyl-terminal hydrolase 7 or herpesvirus-associated ubiquitin-specific protease...
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Ub-AMC (redirect from Ubiquitin-AMC)
Ubiquitin-AMC is a fluorogenic substrate for a wide range of deubiquitinating enzymes (DUBs), including ubiquitin C-terminal hydrolases (UCHs) and ubiquitin...
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Prokaryotic ubiquitin-like protein (Pup) is a functional analog of ubiquitin found in the prokaryote Mycobacterium tuberculosis. Like ubiquitin, Pup serves...
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CBL (gene) (redirect from Cbl ubiquitin ligase)
gene, a part of the Cbl family, encodes the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination...
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terminus include ubiquitin-protein ligase, which regulates ubiquitination of CDC25. Ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating...
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Ubiquitin specific peptidase 54 is a protein that in humans is encoded by the USP54 gene. GRCh38: Ensembl release 89: ENSG00000166348 – Ensembl, May 2017...
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Parkin is a 465-amino acid residue E3 ubiquitin ligase, a protein that in humans and mice is encoded by the PARK2 gene. Parkin plays a critical role in...
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Ubiquitin C-terminal hydrolase may refer to: Ubiquitin carboxy-terminal hydrolase L1, an enzyme Ubiquitinyl hydrolase 1, an enzyme This set index page...
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