DNA methylation is a biological process by which methyl groups are added to the DNA molecule. Methylation can change the activity of a DNA segment without...
114 KB (13,179 words) - 02:59, 22 July 2024
guanine in the DNA sequence). In mammals, DNA methylation is common in body cells, and methylation of CpG sites seems to be the default. Human DNA has about...
28 KB (3,051 words) - 10:03, 4 June 2024
DNA methylation in cancer plays a variety of roles, helping to change the healthy cells by regulation of gene expression to a cancer cells or a diseased...
30 KB (3,792 words) - 07:03, 18 October 2023
CpG site (category DNA)
vertebrate DNA because the cytosines in such an arrangement tend to be methylated. This methylation helps distinguish the newly synthesized DNA strand from...
51 KB (5,481 words) - 20:28, 15 August 2024
Epigenetics (section DNA methylation)
such changes are DNA methylation and histone modification, each of which alters how genes are expressed without altering the underlying DNA sequence. Further...
161 KB (18,346 words) - 02:11, 20 August 2024
Bisulfite sequencing (redirect from Methylation specific PCR)
the use of bisulfite treatment of DNA before routine sequencing to determine the pattern of methylation. DNA methylation was the first discovered epigenetic...
34 KB (4,084 words) - 21:59, 8 January 2024
of DNA adducts- ethanoates, oxidized bases, alkylated phosphodiesters and crosslinking of DNA, just to name a few. UV damage, alkylation/methylation, X-ray...
129 KB (15,900 words) - 06:12, 13 August 2024
Epigenomics (section DNA methylation)
the primary DNA sequence and that are heritable mitotically and meiotically are classified as epigenetic modifications. DNA methylation and histone modification...
43 KB (5,120 words) - 18:37, 28 July 2024
RNA-directed DNA methylation (RdDM) is a biological process in which non-coding RNA molecules direct the addition of DNA methylation to specific DNA sequences...
139 KB (14,822 words) - 02:25, 16 July 2024
Epigenome (section DNA methylation)
changes to the function of the genome. The human epigenome, including DNA methylation and histone modification, is maintained through cell division (both...
34 KB (3,801 words) - 02:03, 8 August 2024
biochemistry, the DNA methyltransferase (DNA MTase, DNMT) family of enzymes catalyze the transfer of a methyl group to DNA. DNA methylation serves a wide...
33 KB (3,598 words) - 17:16, 28 March 2024
Cellular differentiation (section DNA methylation)
expression is further achieved through DNA methylation, in which the DNA methyltransferase-mediated methylation of cytosine residues in CpG dinucleotides...
50 KB (6,033 words) - 03:30, 25 July 2024
Endurance (section Endurance exercise-induced alteration to gene expression by DNA methylation or demethylation)
untrained leg, had significant DNA methylation changes at 4,919 sites across the genome. The sites of altered DNA methylation were predominantly in enhancers...
16 KB (1,520 words) - 20:27, 9 August 2024
Germline (section DNA damage, mutation and repair)
alteration is the methylation of DNA cytosine to form 5-methylcytosine. This usually occurs in the DNA sequence CpG, changing the DNA at the CpG site from...
17 KB (2,080 words) - 17:17, 26 April 2024
sites have a methylated cytosine. Methylation of cytosine in DNA has a major role in regulating gene expression. Methylation of CpGs in a promoter region of...
102 KB (11,438 words) - 16:50, 17 July 2024
Transcription (biology) (redirect from DNA transcription)
enhancers. The binding of EGR1 to its target DNA binding site is insensitive to cytosine methylation in the DNA. While only small amounts of EGR1 transcription...
58 KB (6,787 words) - 20:17, 9 August 2024
One current hypothesis for how DNA methylation contributes to the storage of memories is that dynamic DNA methylation changes occur temporally to activate...
52 KB (6,235 words) - 15:49, 26 April 2024
process called DNA methylation. The enzyme is encoded in humans by the DNMT3A gene. This enzyme is responsible for de novo DNA methylation. Such function...
34 KB (3,924 words) - 10:55, 28 March 2024
based on DNA methylation levels, measuring the accumulation of methyl groups to one's DNA molecules. The strong effects of age on DNA methylation levels...
59 KB (6,367 words) - 16:26, 26 June 2024
has only a small amount of DNA methylation (black line in Figure). DNMT3b begins to be expressed in the blastocyst. Methylation begins to increase at 3.5...
42 KB (5,154 words) - 13:37, 14 February 2024
Epigenetics in stem-cell differentiation (section DNA methylation in differentiated versus undifferentiated cells)
commitment of stem cells is controlled by epigenetic mechanisms such as DNA methylation, histone modifications and regulation of ATP-dependent remolding of...
28 KB (3,692 words) - 22:45, 3 December 2023
Regulation of gene expression (category DNA)
of DNA can depend on its chromatin structure, which can be altered as a result of histone modifications directed by DNA methylation, ncRNA, or DNA-binding...
45 KB (5,235 words) - 16:05, 28 June 2024
tissue types. Studies have shown differences in epigenetic markers like DNA methylation, histone modifications and miRNA expression between smokers and non-smokers...
14 KB (1,902 words) - 19:47, 29 June 2024
Epigenetics of schizophrenia (section DNA methylation)
that risk loci are commonly found near DNA methylation quantitative trait loci (which affect CpG methylation), which have post-transcriptional modifications...
44 KB (5,482 words) - 19:47, 29 June 2024
Whole genome bisulfite sequencing (category DNA sequencing)
the DNA methylation status of single cytosines by treating the DNA with sodium bisulfite before high-throughput DNA sequencing. The DNA methylation status...
22 KB (2,517 words) - 05:07, 4 July 2024
methylation patterns in the DNA. Physical exercise is one such factor that also has been shown to affect methylation and chromatin modifications. DNA...
73 KB (8,901 words) - 12:36, 16 August 2024
Environmental epigenetics (section DNA methylation)
DNA methylation and histone modification are responsible for how the genome is altered. For example, the suppression of oncogenes is regulated by DNA...
14 KB (1,730 words) - 22:12, 19 May 2024
include histone modification, DNA methylation and demethylation, and microRNA (miRNA) expression. Histones keep the DNA of the eukaryotic cell tightly...
44 KB (5,725 words) - 00:49, 4 April 2024
Memory (section DNA methylation and demethylation)
memory include the methylation and demethylation of neuronal DNA, as well as modifications of histone proteins including methylations, acetylations and...
128 KB (16,049 words) - 03:33, 29 July 2024
examination of a genome-wide set of quantifiable epigenetic marks, such as DNA methylation, in different individuals to derive associations between epigenetic...
32 KB (3,597 words) - 15:04, 21 April 2024