ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13)—also known as von Willebrand factor-cleaving protease (VWFCP)—is...
12 KB (1,420 words) - 09:40, 14 January 2024
underlying mechanism typically involves antibodies inhibiting the enzyme ADAMTS13. This results in decreased break down of large multimers of von Willebrand...
43 KB (4,127 words) - 00:31, 8 July 2024
Apadamtase alfa (redirect from ADAMTS13, recombinant-krhn)
Manufacturing Austria AG. The active substance of Adzynma is recombinant ADAMTS13 (rADAMTS13). "Adzynma- apadamtase alfa kit". DailyMed. 9 November 2023. Retrieved...
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complex blood coagulation disease. USS is caused by the absence of the ADAMTS13 protease resulting in the persistence of ultra large von Willebrand factor...
35 KB (3,483 words) - 18:10, 9 June 2024
must partially unfold to expose the buried cleavage site for the specific ADAMTS13 protease that inactivates VWF by making much smaller multimers. The partial...
17 KB (2,121 words) - 20:13, 5 June 2024
ADAMTS13 endopeptidase (EC 3.4.24.87, ADAMTS VWF cleaving metalloprotease, ADAMTS-13, ADAMTS13, vWF-cleaving protease, VWF-CP, vWF-degrading protease,...
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factor levels increase the risk of first ischemic stroke: influence of ADAMTS13, inflammation, and genetic variability". Stroke. 37 (11): 2672–7. doi:10...
184 KB (20,394 words) - 15:54, 8 July 2024
Shiga-toxin/EHEC test confirms a cause for STEC-HUS, and severe ADAMTS13 deficiency (i.e., ≤5% of normal ADAMTS13 levels) confirms a diagnosis of TTP. The effect of...
55 KB (5,697 words) - 15:34, 15 January 2024
into its active state, it is degraded by its natural catabolic enzyme ADAMTS13, rendering it incapable of binding the collagen at an injury site. As the...
24 KB (2,582 words) - 20:25, 3 December 2023
Cys1584 variant of vWF (an amino acid polymorphism in VWF): the gene for ADAMTS13 (vWF-cleaving protease) maps to human chromosome 9 band q34.2, the same...
59 KB (5,991 words) - 21:07, 6 July 2024
thrombocytopenic purpura arise from autoantibody-mediated inhibition of ADAMTS13. Like ADAMs, the name of the ADAMTS family refers to its disintegrin and...
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therapeutic plasma exchange, as for TTP. Unlike TTP, no deficient ADAMTS13 activity nor anti-ADAMTS13 antibody was found indicating a thrombotic microangiopathy...
35 KB (3,414 words) - 11:52, 1 June 2024
Congenital and idiopathic TTP are generally associated with deficiencies in ADAMTS13, a zinc metalloprotease responsible for cleaving Very Large vWF Multimers...
11 KB (1,202 words) - 05:01, 14 June 2024
activity of the von Willebrand factor-cleaving protease ADAMTS13. Hereditary TTP, caused by ADAMTS13 gene mutations, is much less common. Congenital or inherited...
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characterized by mutations in the ADAMTS13 gene leading to severe ADAMTS13 deficiency. This congenital cause of ADAMTS13 deficiency is called Upshaw-Schülman...
38 KB (4,166 words) - 08:48, 30 May 2024
(adults), 50 per 100,000 (children) Thrombotic thrombocytopenic purpura ADAMTS13 autoantibodies Confirmed 1-2 per million Antiphospholipid syndrome Antiphospholipid...
94 KB (6,052 words) - 07:45, 11 June 2024
electrophoresis due to impaired multimer assembly or increased susceptibility to ADAMTS13 (a protease that cleaves VWF). Factor VIII activity can be normal or low...
44 KB (5,495 words) - 02:56, 7 July 2024
Q9P2N4 280 ADAMTS10 HGNC:13201 Q9H324 281 ADAMTS12 HGNC:14605 P58397 282 ADAMTS13 HGNC:1366 Q76LX8 283 ADAMTS14 HGNC:14899 Q8WXS8 284 ADAMTS15 HGNC:16305...
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doctors who performed the full autopsy. Thrombotic thrombocytopenic purpura ADAMTS13 John Vivian Dacie Marcus, Jacob Rader & Daniels, Judith M. (Ed.): The concise...
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the treatment of several types of cancer. ADAMTS1; ADAMTS10; ADAMTS12; ADAMTS13; ADAMTS14; ADAMTS15; ADAMTS16; ADAMTS17; ADAMTS18; ADAMTS19; ADAMTS2; ADAMTS20;...
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which the reduced activity of the von Willebrand factor-cleaving protease ADAMTS13 causes a thrombotic microangiopathy. This disease, acquired or hereditary...
28 KB (3,023 words) - 17:23, 9 July 2024
syndrome-associated Shiga toxins promote endothelial-cell secretion and impair ADAMTS13 cleavage of unusually large von Willebrand factor multimers". Blood. 106...
41 KB (4,463 words) - 15:48, 8 June 2024
85: S2P endopeptidase EC 3.4.24.86: ADAM 17 endopeptidase EC 3.4.24.87: ADAMTS13 endopeptidase EC 3.4.25.1: proteasome endopeptidase complex EC 3.4.25.2:...
119 KB (15,553 words) - 03:35, 27 April 2024
nearly single amino acid residue resolution reveals novel exosites on ADAMTS13 critical for substrate recognition and mechanism of autoimmune thrombotic...
23 KB (2,661 words) - 04:37, 28 April 2024
group glycosyltransferases ACTL7A: encoding protein Actin-like protein 7A ADAMTS13: ADAM metallopeptidase with thrombospondin type 1 motif, 13 AIF1L: allograft...
26 KB (1,594 words) - 01:50, 11 April 2024
divided into three groups: procollagen aminopeptidase, aggrecanase, and ADAMTS13 which cleaves von Willebrand factor. Unlike with MMPs, TIMPs are more selective...
50 KB (5,450 words) - 01:03, 22 June 2024
and skin), which causes the signs and symptoms of the disorder. ADAMTS5 ADAMTS13 GRCm38: Ensembl release 89: ENSMUSG00000036545 – Ensembl, May 2017 "Human...
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families, which include important protease enzymes. The secreted protease ADAMTS13, found in serum, cleaves Von Willebrand factor and acts as a natural, endogenous...
10 KB (1,167 words) - 02:39, 6 January 2024
hyperhomocysteinemic; 236200; CBS Thrombotic thrombocytopenic purpura, familial; 274150; ADAMTS13 Thryoid dyshormonogenesis 6; 607200; DUOX2 Thyroid carcinoma, follicular;...
234 KB (18,877 words) - 15:43, 9 May 2024