Interferon-inducible protein AIM2 also known as absent in melanoma 2 or simply AIM2 is a protein that in humans is encoded by the AIM2 gene. AIM2 is a cytoplasmic...
16 KB (1,981 words) - 01:28, 27 January 2024
Inflammasome (section AIM2 inflammasome)
(nucleotide-binding oligomerization domain and leucine-rich repeat-containing receptors), AIM2 (absent in melanoma 2), IFI16 (IFN-inducible protein 16), and pyrin. Through...
71 KB (7,819 words) - 07:03, 17 June 2024
PAMPs and DAMPs stimuli. Some non-NLR proteins like absent in melanoma 2 (AIM2) and pyrin can also be activated and form inflammasomes. Also, non-inflammasome-forming...
35 KB (3,948 words) - 06:00, 10 June 2024
in melanoma 2-like (AIM2-like) receptors function as recognition of foreign double stranded DNA. Two ALRs with pyrin domains, AIM2 and IFI16, assemble...
14 KB (1,163 words) - 16:52, 28 November 2023
Thirumala-Devi Kanneganti (section Discovery of NLRP3 inflammasome, ZBP1-, RIPK1-, AIM2-, and NLRP12-PANoptosomes, and PANoptosis as therapeutic targets for infectious and inflammatory diseases and cancer)
negatively regulating the NLRP3 inflammasome and inflammatory cell death The AIM2-PANoptosome responds to Francisella and herpes simplex virus 1 infections...
44 KB (4,323 words) - 10:21, 27 March 2024
binding site for AIM2, meaning that it is necessary for the transcription of AIM2. Researchers had shown this by deleting MER41.AIM2 in HeLa cells using...
69 KB (8,298 words) - 15:39, 26 April 2024
mediators of Caspase-1 activation are: NOD-like Leucine Rich Repeats (NLRs), AIM2-Like Receptors (ALRs), Pyrin and IFI16. These proteins allow caspase-1 activation...
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HGNC:21411 Q9BRQ8 475 AIFM3 HGNC:26398 Q96NN9 476 AIG1 HGNC:21607 Q9NVV5 477 AIM2 HGNC:357 O14862 478 AIMP1 HGNC:10648 Q12904 479 AIMP2 HGNC:20609 Q13155 480...
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(interleukin-1B, interleukin 1 RN, CASP1, interleukin 18 RAP) and interferon induced (AIM2, IP-10/CXCL10) genes. T cell associated genes (CD3, CD8B) are down regulated...
9 KB (880 words) - 00:31, 13 December 2023
TLR2, TLR4, RAGE HMGN1 TLR4 IL-1α IL-1R IL-33 ST2 SAP130 Mincle DNA TLR9, AIM2 RNA TLR3, TLR7, TLR8, RIG-I, MDA5 Mitochondria mtDNA TLR9 TFAM RAGE Formyl...
35 KB (3,558 words) - 11:06, 26 June 2024
different eukaryotic organisms including mentioned above human factors: AIM1, AIM2, and AIM3 (Xie et al., 2005), yeast factors NDI1 and AIF1 as well as AIF...
9 KB (1,121 words) - 00:24, 2 December 2023
by some members of Nod-like receptor family (NLRs), absent in melanoma 2 (AIM2) or pyrin leads to the assembly of an inflammasome structure and caspase...
19 KB (2,056 words) - 13:42, 25 May 2024
conditions, and cancer. Several PANoptosome complexes, such as the ZBP1-, AIM2-, RIPK1-, NLRC5- and NLRP12-PANoptosomes, have been characterized so far...
37 KB (3,773 words) - 09:04, 24 June 2024
A signalling complex involved in necrotic cell death. Inflammasomes: The AIM2 and NLRP3 inflammasomes are filamentous assemblies that elicit host defense...
7 KB (765 words) - 16:39, 12 May 2024
Esparo NM, Child SJ, Geballe AP PLOS Pathogens. 2016 Oct; 12 10: e1005966 The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular...
5 KB (437 words) - 00:04, 22 December 2022
component cytoplasm NLRP3 inflammasome complex NLRP1 inflammasome complex AIM2 inflammasome complex nucleolus endoplasmic reticulum mitochondrion IkappaB...
10 KB (1,338 words) - 23:55, 12 April 2024
complex cytoplasm cytosol NLRP1 inflammasome complex extracellular region AIM2 inflammasome complex mitochondrion IPAF inflammasome complex protease inhibitor...
21 KB (2,394 words) - 03:59, 17 June 2024
Levine, R. L.; Reilly, M. P.; Libby, P.; Wang, N.; Tall, A. R. (2021). "The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis". Nature...
15 KB (1,606 words) - 00:49, 2 June 2024
well as the high expression of inflammasome molecules NLRP-1, NLRP-3, and AIM2 point to innate immune functions of LSECs. In addition, LSECs display features...
20 KB (2,418 words) - 10:16, 2 June 2024
et al. (May 2015). "Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida". Nature Immunology...
11 KB (1,262 words) - 21:07, 28 June 2024
Gabor; Caffrey, Daniel. R.; Latz, Eicke; Fitzgerald, Katherine A. (2009). "AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome...
11 KB (907 words) - 00:19, 17 November 2023
apoptotic signaling pathway Cellular component NLRP3 inflammasome complex AIM2 inflammasome complex IPAF inflammasome complex endoplasmic reticulum cytoplasm...
6 KB (665 words) - 07:46, 7 July 2024
Coord Patrol (CORPAT) & 3rd Bilat-Ex betwn IN & Indonesian Navy with an aim2 foster maritime ties with countries located on rim of IORpic.twitter.com/M0nd8cFkdK"...
202 KB (10,126 words) - 20:32, 14 June 2024
Probable ATP-dependent RNA helicase DDX10 1) it promotes AIM2-inflammasome activation by maintaining AIM2 protein stability. 2) it promotes human lung carcinoma...
32 KB (1,905 words) - 05:55, 17 June 2024