dihydrodiol dehydrogenase type 2, is an enzyme that in humans is encoded by the AKR1C2 gene. This gene encodes a member of the aldo/keto reductase superfamily...
8 KB (1,053 words) - 03:42, 12 August 2024
most studied isoforms are type 1 (AKR1C4), type 2 (AKR1C3) and type 3 (AKR1C2). Each of these isoforms shares higher than 70% sequence homology and common...
16 KB (1,731 words) - 18:52, 12 October 2024
Although both AKR1C2 and AKR1C4 enzymes are needed for DHT synthesis in a backdoor pathway, the study found that mutations in AKR1C2 only were sufficient...
79 KB (8,735 words) - 07:29, 14 October 2024
(AKRs) AKR1C1, AKR1C2, and AKR1C4 with high catalytic efficiency. AKR1C1 preferentially forms 20α-hydroxy-5α-pregnane-3-one while AKR1C2 preferentially...
10 KB (909 words) - 23:12, 9 November 2023
Okada, Hiroshi; Kawato, Suguru; Horie, Shigeo (April 2018). "Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer". Cancer...
27 KB (3,041 words) - 12:23, 8 October 2024
HGNC:382 O60218 519 AKR1B15 HGNC:37281 C9JRZ8 520 AKR1C1 HGNC:384 Q04828 521 AKR1C2 HGNC:385 P52895 522 AKR1C3 HGNC:386 P42330 523 AKR1C4 HGNC:387 P17516 524...
277 KB (17 words) - 18:34, 6 October 2024
human types 1 and 3 3α-HSD, 20α-HSD, and type 5 17β-HSD were named AKR1C4, AKR1C2, AKR1C1, and AKR1C3, respectively 3α-Hydroxysteroid dehydrogenase Human...
9 KB (1,146 words) - 15:16, 12 May 2024
(AKR1C1), 1Q13, and 1Q5M. AKR1C1, AKR1C2, and AKR1C3 AKR1C1 has high catalytic efficiency as a 20α-HSD and AKR1C2 and AKR1C3 efficiently catalyze this...
7 KB (808 words) - 16:09, 22 September 2024
carcinoma of esophageus and its normal epithelium; altered pattern of mal, akr1c2, and rab11a expression". World Journal of Gastroenterology. 10 (12): 1716–21...
8 KB (990 words) - 22:08, 21 September 2024
progesterone, formed by the 20α-hydroxysteroid dehydrogenases (20α-HSDs) AKR1C1, AKR1C2, and AKR1C3 and the 17β-hydroxysteroid dehydrogenase (17β-HSD) HSD17B1....
10 KB (879 words) - 07:57, 18 August 2023
novel disorder of fetal androgen synthesis involving aldo-keto reductases (AKR1C2 and AKR1C4), showing that both the conventional and alternative ("backdoor")...
19 KB (1,915 words) - 17:15, 31 May 2024
human types 1 and 3 3α-HSD, 20α-HSD, and type 5 17β-HSD were named AKR1C4, AKR1C2, AKR1C1, and AKR1C3, respectively Binstock JM, Iyer RB, Hamby CV, Fried...
12 KB (1,424 words) - 05:38, 24 August 2024
3α-hydroxysteroid dehydrogenase (3α-HSD), i.e. by the two aldo-keto reductase isozymes: AKR1C2 and AKR1C4, and by 17β-hydroxysteroid dehydrogenase 6 (HSD17B6) that also...
14 KB (1,217 words) - 08:11, 20 August 2024
acts as the sole 5β-reductase in humans. AKR1A1; AKR1B1; AKR1B10; AKR1C1; AKR1C2; AKR1C3; AKR1C4; AKR1D1; Others Steroidogenic enzyme Rižner TL, Penning...
2 KB (161 words) - 18:17, 17 December 2020
human types 1 and 3 3α-HSD, 20α-HSD, and type 5 17β-HSD were named AKR1C4, AKR1C2, AKR1C1, and AKR1C3, respectively Human AKR1C3 genome location and AKR1C3...
12 KB (1,528 words) - 15:02, 7 September 2024