also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene and is involved in the unfolded protein response. ATF6 is an endoplasmic...

(April 2002). "The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi". The Journal...

in maintaining homeostasis. Some of these ATFs, such as ATF3, ATF4, and ATF6 are known to play a role in stress responses. Another example of ATFs function...

phosphodiesterase PDE6C (ACHM5, OMIM 613093) and PDEH (ACHM6, OMIM 610024), and ATF6 (ACHM7, OMIM 616517). The hemeralopic aspect of achromatopsia can be diagnosed...

inositol-requiring kinase 1 (IRE1), and activating transcription factor 6 (ATF6). They respond to high levels of misfolded proteins in the ER through intracellular...

improperly folded protein. GRP78 is normally bound to the luminal domain of ATF6, IRE1, and PERK, which prevents them from initiating their respective pathways...

ENSG00000169136 bZIP Known motif – In vivo/Misc source [46] WAAGGRAGARR ATF6 ENSG00000118217 bZIP Known motif – High-throughput in vitro [47] YKRTGACGTGGCA...

Matsui T, Yamamoto A, Okada T, Mori K (2001). "XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription...

proteins mediating protein homeostasis. Different “detectors” - such as IRE1, ATF6 and PERK - can recognize misfolded proteins in the ER and mediate transcriptional...

element-binding protein (SREBP)-1, SREBP-2 and forms of the transcriptional activator ATF6. This enzyme belongs to the peptidase family M50. This gene encodes an intramembrane...

endoplasmic reticulum kinase (PERK), activating transcription factor 6 (ATF6), and inositol requiring protein 1 (IRE1α) During ER stress, CHOP is mainly...

HGNC:785 P18847 1186 ATF4 HGNC:786 P18848 1187 ATF5 HGNC:790 Q9Y2D1 1188 ATF6 HGNC:791 P18850 1189 ATF6B HGNC:2349 Q99941 1190 ATF7 HGNC:792 P17544 1191...

ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways". FASEB J. 24 (1): 296–308. doi:10...

During ER stress, BiP dissociates from the three transducers (IRE1, PERK, and ATF6), effectively activating their respective UPR pathways. As a UPR target gene...

substrate. FICD has been linked to many cellular pathways, most notably the ATF6 and PERK branches of the UPR (unfolded protein response) pathway regulating...

chaperone-mediated protein folding response to estradiol response to testosterone ATF6-mediated unfolded protein response positive regulation of substrate adhesion-dependent...

NM_005171 ATF2 NM_001880 ATF4 Activating transcription factor 4 NM_001675 ATF6 NM_007348 ATF7 NM_001206682 ATF7IP NM_018179 BTF3 NM_001207 Homo sapiens...

(2007). "Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation". J. Biol. Chem. 282 (40): 29264–72. doi:10.1074/jbc.M705038200...

kernels NFE2L2 or Nrf2 Bzip Maf transcription factors ATF1; ATF2; ATF4; ATF5; ATF6; ATF7; BACH1; BACH2; BATF; BATF2; CEBPA; CEBPB; CEBPD; CEBPE; CEBPG; CEBPZ;...

the families of affected individuals. YY1 has been shown to interact with: ATF6, EP300 FKBP3 HDAC3 Histone deacetylase 2 Myc NOTCH1 RYBP and SAP30 Serine—tRNA...

UPRER that restores protein homeostasis via three pathways (IRE1, PERK, and ATF6). The UPRER restores proteostasis by selectively attenuation protein translation...

(February 2002). "IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response"...

diseases. Serum response factor has been shown to interact with: ASCC3, ATF6, CEBPB, CREB-binding protein, ELK4, GATA4, GTF2F1, GTF2I, Myogenin, NFYA...

(September 2002). "Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum...

chaperones, which are induced by the activating transcription factor 6 (ATF6). If the number of erroneous proteins elevates, further mechanism is active...

sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response". Proceedings of the National Academy of...

ubiquitin-dependent protein catabolic process autophagy multicellular organism development ATF6-mediated unfolded protein response IRE1-mediated unfolded protein response...

Kyoto University since 1999. Meanwhile, he completed the copying of HAC1, ATF6 and BP1. The independent works of Mori and Peter Walter during the same period...

oriented in the cytosol. Other membrane bound basic leucine zippers include ATF6 and OASIS. Known nuclear transportation routes for membrane bound transcription...

Komuro R, et al. (2001). "ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs". Mol. Cell. 6 (6): 1355–64. doi:10...