Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Identified in 1986, activin enhances...
26 KB (2,557 words) - 08:59, 5 August 2024
An Activin receptor is a receptor which binds activin. These proteins are receptor-type kinases of Ser/Thr type, which have a single transmembrane domain...
2 KB (174 words) - 10:58, 22 March 2023
pulmonary arterial hypertension. It is an activin signaling inhibitor, based on the extracellular domain of the activin type 2 receptor expressed as a recombinant...
23 KB (1,570 words) - 04:15, 29 August 2024
Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene. ACVR2B is an activin type 2 receptor. Activins are dimeric growth and...
11 KB (1,346 words) - 02:52, 22 July 2024
in the gene ACVR1 (also known as activin-like kinase 2 (ALK2)) is responsible for the disease. ACVR1 encodes activin receptor type-1, a BMP type-1 receptor...
34 KB (3,590 words) - 17:49, 31 August 2024
scientists reported that suppressing activin type 2 receptors-signalling proteins myostatin and activin A via activin A/myostatin inhibitor ACVR2B – tested...
48 KB (5,338 words) - 15:38, 6 September 2024
The activin type 2 receptors belong to a larger TGF-beta receptor family and modulate signals for transforming growth factor beta ligands. These receptors...
6 KB (583 words) - 15:40, 29 March 2023
inhibiting the production of GnRH in the hypothalamus. Inhibin acts to inhibit activin, which is a peripherally produced hormone that positively stimulates GnRH-producing...
20 KB (2,454 words) - 08:21, 31 May 2024
Follistatin, also known as activin-bindings protein, is a protein that in humans is encoded by the FST gene. Follistatin is an autocrine glycoprotein...
19 KB (2,169 words) - 14:40, 2 September 2024
The Activin type I receptors transduce signals for a variety of members of the Transforming growth factor beta superfamily of ligands. This family of...
1 KB (143 words) - 19:20, 26 May 2024
ACVRL1 (redirect from Activin receptor-like kinase I)
ACVRL1 is a receptor in the TGF beta signaling pathway. It is also known as activin receptor-like kinase 1, or ALK1. This gene encodes a type I cell-surface...
14 KB (1,801 words) - 02:46, 6 May 2024
Activin A receptor, type I (ACVR1) is a protein which in humans is encoded by the ACVR1 gene; also known as ALK-2 (activin receptor-like kinase-2). ACVR1...
9 KB (1,052 words) - 01:13, 22 January 2024
Activin receptor type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A...
12 KB (1,427 words) - 20:41, 13 August 2023
inhibitors also reduce the activity of related proteins such as GDF11, activins, and bone morphogenetic proteins. While this off target activity can increase...
11 KB (1,195 words) - 00:18, 21 June 2024
Activin receptor type-1B is a protein that in humans is encoded by the ACVR1B gene. ACVR1B or ALK-4 acts as a transducer of activin or activin-like ligands...
12 KB (1,542 words) - 05:48, 28 March 2024
Transforming growth factor beta receptor I (activin A receptor type II-like kinase, 53kDa) is a membrane-bound TGF beta receptor protein of the TGF-beta...
14 KB (1,618 words) - 02:37, 2 April 2024
important role in puberty. Activin A is a dimeric glycoprotein that is a member of the transforming growth factor-β (TGF-β) family. Activin A is responsible for...
18 KB (1,858 words) - 03:18, 6 June 2024
which in humans is encoded by the INHBA gene. INHBA is a subunit of both activin and inhibin, two closely related glycoproteins with opposing biological...
9 KB (1,109 words) - 18:55, 11 April 2024
treat pathological muscle loss and weakness. It binds to and inhibits activin receptor type-2B. Bimagrumab must be administered intravenously at a hospital...
5 KB (365 words) - 20:04, 20 December 2023
and hypothalamic hormones Nerve cell survival factors 3 Activins: Activin A, Activin B and Activin AB. Glial-Derived Neurotrophic Factor (GDNF) Needed for...
46 KB (4,967 words) - 21:12, 7 July 2024
receptors and five type II receptors. There are three activins: Activin A, Activin B and Activin AB. Activins are involved in embryogenesis and osteogenesis...
20 KB (2,098 words) - 00:36, 28 November 2023
TGF beta receptor (redirect from Activin-like receptor)
transforming growth factor beta, receptor type I (activin A receptor type II-like kinase, 53kDa) Identifiers Symbol TGFBR1 Alt. symbols ALK5 NCBI gene...
4 KB (334 words) - 01:11, 14 December 2022
BAMBI (redirect from Bone and Activin membrane bound inhibitor)
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis), also known as BAMBI, is a protein which in humans is encoded by the BAMBI gene. This...
7 KB (930 words) - 01:40, 6 September 2023
hormone (MIH), is a glycoprotein hormone structurally related to inhibin and activin from the transforming growth factor beta superfamily, whose key roles are...
41 KB (4,871 words) - 06:27, 18 June 2024
embryos. Activation of the Nodal pathway involves nodal binding to activin and activin-like receptors which leads to phosphorylation of the Smad2. The P-Smad2/Smad4...
27 KB (3,398 words) - 18:33, 6 July 2024
myostatin. It does not bind to active myostatin, activin A, active BMP9/10 or TGFβ1 that all operate on the activin type 2 receptors. Barrett, Doreen; Bilic,...
5 KB (259 words) - 10:47, 12 November 2023
The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene. ACVR1C is a type I receptor for the TGFB...
7 KB (896 words) - 13:37, 22 July 2023
physiology of inhibin and activin in pituitary and ovarian function in rodent and the effects of recombinant human inhibin and activin in primates. Woodruff...
20 KB (1,915 words) - 17:38, 31 August 2024
Testis Testosterone AMH Inhibin Ovary Estradiol Progesterone Activin Inhibin Relaxin GnSAF Placenta hCG HPL Estrogen Progesterone...
39 KB (4,603 words) - 19:02, 5 September 2024