In eukaryotic cells, an aggresome refers to an aggregation of misfolded proteins in the cell, formed when the protein degradation system of the cell is...

were shortened by mutations. Lewy bodies are believed to represent an aggresome response in the cell. When misfolded proteins aggregate, or clump together...

some are not. Note the following four examples: HDAC6 is associated with aggresomes. Misfolded protein aggregates are tagged by ubiquitination and removed...

"The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation". Journal of Cell Science. 115 (Pt 14): 2907–2918. doi:10.1242/jcs...

bodies in neurodegenerative diseases are aggregates of misfolded proteins (aggresomes) and are hallmarks of many of these diseases, including Lewy bodies in...

rely on cholesteryl esters derived from LDL. Vimentin plays a role in aggresome formation, where it forms a cage surrounding a core of aggregated protein...

autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS). Autophagy, 7: 29–31. Fujita K, Xiao Q...

overworked. In mammalian cells, these protein aggregates are termed "aggresomes" and they are formed when the cell is diseased. This is because aggregates...

endosome PML body late endosome P-body phagophore assembly site nucleoplasm aggresome autophagosome amphisome endoplasmic reticulum inclusion body lysosome...

perinuclear region of cytoplasm nucleus Lewy body SCF ubiquitin ligase complex aggresome endoplasmic reticulum Golgi apparatus Parkin-FBXW7-Cul1 ubiquitin ligase...

viral factories of the ASFV viroplasm is very similar to the aggresome formation. An aggresome is a perinuclear site where misfolded proteins are transported...

efficacy of mammalian cells may be limited by epigenetic gene silencing and aggresome formation (recombinant protein aggregation). For mammalian cells, synthesised...

reticulum stress response (ER stress) Mitochondrial unfolded protein response Aggresome PERK inhibitors Hetz C, Papa FR (January 2018). "The Unfolded Protein...

membrane membrane intracellular membrane-bounded organelle plasma membrane aggresome ciliary membrane clathrin-coated pit AP-2 adaptor complex clathrin-coated...

function proteasome binding protein binding Cellular component cytoplasm aggresome nucleus fibrillar center cytosol Biological process positive regulation...

novo purine biosynthesis. However, nocodazole also blocks formation of aggresomes, complicating interpretation of these observations. Partial inhibition...

clathrin-coated vesicle cytoplasm cytoplasmic vesicle nucleus cytosol nucleoplasm aggresome lateral plasma membrane nuclear body Biological process non-canonical...

binding Cellular component cytoplasm membrane plasma membrane nucleoplasm aggresome autophagosome endoplasmic reticulum perinuclear region of cytoplasm proteasome...

binding Cellular component cytoplasm cytosol endosome membrane nucleoplasm aggresome Biological process phosphorylation positive regulation of interferon-alpha...

region cytoskeleton nucleus kinetochore axon cytoplasm cytoplasm cytosol aggresome perinuclear region of cytoplasm nuclear envelope nucleoplasm spindle nuclear...

Tabrizi, Sarah J. (18 November 2005). "Disease-related Prion Protein Forms Aggresomes in Neuronal Cells Leading to Caspase Activation and Apoptosis". Journal...

ubiquitin-dependent protein catabolic process protein hexamerization aggresome assembly flavin adenine dinucleotide catabolic process proteasome-mediated...

neuron projection cytoskeleton presynaptic membrane mitochondrion cytosol aggresome synaptic vesicle trans-Golgi network membrane postsynaptic early endosome...

exonuclease activity hydrolase activity Cellular component membrane nucleoplasm aggresome nucleotide-excision repair complex nucleus delta DNA polymerase complex...

ATPase activity helicase activity hydrolase activity Cellular component aggresome nucleus nucleoplasm cytosol site of DNA damage chromosome Biological process...

reticulum endoplasmic reticulum quality control compartment Golgi membrane aggresome Biological process N-glycan processing positive regulation of retrograde...

II-specific Cellular component nucleus nucleoplasm nucleolus cytosol aggresome Biological process cardiac septum development heart valve development...

parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy...

Szebenyi G, Wigley WC, Hall B, et al. (2007). "Hook2 contributes to aggresome formation". BMC Cell Biol. 8: 19. doi:10.1186/1471-2121-8-19. PMC 1896156...

3'-5'-exoribonuclease activity RNA binding Cellular component membrane aggresome nucleolus nucleus nucleoplasm Biological process RNA processing regulation...