Aquaporin-4, also known as AQP-4, is a water channel protein encoded by the AQP4 gene in humans. AQP-4 belongs to the aquaporin family of integral membrane...

Aquaporins, also called water channels, are channel proteins from a larger family of major intrinsic proteins that form pores in the membrane of biological...

presence of serum antibodies directed against the water channel protein aquaporin-4 (AQP-4). These antibodies initiate a complement-dependent inflammatory cascade...

than 80% of NMO cases, the cause is immunoglobulin G autoantibodies to aquaporin 4 (anti-AQP4), the most abundant water channel protein in the central nervous...

accomplished through convective bulk flow of ISF, facilitated by astrocytic aquaporin 4 (AQP4) water channels. The name "glymphatic system" was coined by the...

diseases, are a group of diseases characterized by auto-antibodies against aquaporin 4. After the discovery of anti-AQP4 autoantibody in neuromyelitis optica...

the area of the retina which provides finer detail and central vision. Aquaporin 4 in Müller cells in rats transports water to the vitreous body. The vitreous...

Aquaporin 3 (AQP-3) is the protein product of the human AQP3 gene. It is found in the basolateral cell membrane of principal collecting duct cells and...

Aquaporin-2 (AQP-2) is found in the apical cell membranes of the kidney's collecting duct principal cells and in intracellular vesicles located throughout...

been described in some patients with NMOSD who were negative for the aquaporin 4 (AQP-4) antibody. However, most NMOSD is an astrocytopathy, specifically...

characterized by neuromyelitis optica IgG antibodies which selectively bind to aquaporin-4. Optic neuritis is associated monocular vision loss, often initially...

treat neuromyelitis optica spectrum disorder in adults who are anti-aquaporin-4 (AQP4) antibody positive. Eculizumab carries a boxed warning for the...

(NMOSD) in adults with a particular antibody (patients who are anti-aquaporin-4 or AQP4 antibody positive). Neuromyelitis optica spectrum disorder is...

myelitis: characterisation and comparison with aquaporin-4-IgG myelitis". J. Neurol. Neurosurg. Psychiatry. 90 (4): 488–490. doi:10.1136/jnnp-2018-318004. PMID 30032117...

Aquaporin 1 (AQP-1) is a protein that in humans is encoded by the AQP1 gene. AQP-1 is a widely expressed water channel, whose physiological function has...

(March 2016). "Antibodies to myelin oligodendrocyte glycoprotein in aquaporin 4 antibody seronegative longitudinally extensive transverse myelitis: Clinical...

neurosarcoidosis, cerebral angiitis; and specific antibodies such as aquaporin-4 may be tested for to assist in the diagnosis of autoimmune conditions...

disorder (NMOSD) in adults with a particular antibody – people who are anti-aquaporin-4 or AQP4 antibody-positive. NMOSD is a rare autoimmune disease of the...

N-methyl-D-aspartate receptor (NMDA) anti-NMDA receptor encephalitis NMO antibody aquaporin-4 neuromyelitis optica (Devic's syndrome) Anti-desmoglein (anti-desmosome)...

Aquaporin-5 (AQP-5) is a protein that in humans is encoded by the AQP5 gene. Aquaporin-5 (AQP-5) is a water channel protein. Aquaporins are a family of...

ability to detect extracellular fluid osmolarity. Osmoreceptors have aquaporin 4 proteins spanning through their plasma membranes in which water can diffuse...

Myotonia congenita Voltage-dependent chloride channel Neuromyelitis optica Aquaporin-4 water channel Neuromyotonia Voltage-gated potassium channel Nonsyndromic...

Isobe N, Yonekawa T, Matsushita T, et al. Clinical relevance of serum aquaporin-4 antibody levels in neuromyelitis optica. Neurochem Res. 2013;38(5):997-1001...

Aquaporin-9 (AQP-9) is a protein that in humans is encoded by the AQP9 gene. The aquaporins/major intrinsic protein are a family of water-selective membrane...

GABA transporter subtype GAT-3, GFAP, glutamine synthetase, and the Aquaporin 4 channel. Focal lactic acidosis also causes secondary oedema, oxidative...

Subsequent research by Nedergaard and colleagues has revealed that the aquaporin-4 water channel protein plays a crucial role in modulating the flow of...

Robert J.; Saiz, Albert; Dalmau, Josep (February 2015). "Antibodies to Aquaporin 4, Myelin-Oligodendrocyte Glycoprotein, and the Glycine Receptor α1 Subunit...

2023). "Shared imaging markers of fatigue across multiple sclerosis, aquaporin-4 antibody neuromyelitis optica spectrum disorder and MOG antibody disease"...

1 has been shown to interact with Dystrophin, Nav1.1 and Nav1.5, and Aquaporin 4. GRCh38: Ensembl release 89: ENSG00000101400 – Ensembl, May 2017 GRCm38:...

BM, Nielsen S, Agre P (August 1999). "Heterotetrameric composition of aquaporin-4 water channels". Biochemistry. 38 (34): 11156–11163. doi:10.1021/bi990941s...