Bryostatins are a group of macrolide lactones from (bacterial symbionts of) the marine organism Bugula neritina that were first collected and provided...

since been used in the synthesis of several products, particularly the bryostatins. Evans–Tishchenko reaction Saksena, Anil; Mangiaracina, Pietro (1983)...

called bryostatins can be extracted from the marine bryozoan Bugula neritina. In 2001 pharmaceutical company GPC Biotech licensed bryostatin 1 from Arizona...

than was previously achieved. For example, total syntheses of roxaticin, bryostatin and cryptocaryol were accomplished via double Krische allylation of 1...

myricitrin, gossypol. Other PKCIs : Verbascoside, BIM-1, Ro31-8220. Bryostatin 1 can act as a PKC inhibitor; It was investigated for cancer. Tamoxifen...

fish meal), pharmaceuticals (e.g. fish oil, krill oil, cytarabine and bryostatin) and various industrial chemicals (e.g. chitin and bioplastics, formerly...

1998). "Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A". The...

discovery that Bryostatin-1 can be used to treat latent HIV infection and formed the basis for clinical trials on the use of Bryostatin as a latent infection-reversing...

cancer, anti-inflammatory use and pain. One class of these agents are bryostatin-like compounds, under investigation as anti-cancer therapy.[citation needed]...

Endobugula sertula, produces the bryostatins, a group of around twenty bioactive natural products. The bryostatins are under investigation for their...

(IW-2143) – α7 nicotinic acetylcholine receptor negative allosteric modulator Bryostatin 1 (MW-904) – protein kinase C (PKC) stimulant BTRX-246040 (LY-2940094)...

α-cyclodextrin; SFX-01, STP-2; broccoli sprout extract) – various actions Bryostatin-1 (MW-904) – protein kinase C stimulant CJRB-303 (CJRB-901, MRx-0006)...

highly chemoselective oxyfunctionalization of the C-9 position of potent bryostatin analogues". Organic Letters. 7 (1): 79–82. doi:10.1021/ol047859w. PMID 15624982...

Bugula neritina attracted interest as a source of cytotoxic chemicals, bryostatins, under clinical investigation as anti-cancer agents. It was first collected...

elucidation of numerous marine natural products such as the anticancer agent bryostatin, the insecticidal and antifungal jaspamide, diazonamide A and B, and many...

doi:10.1016/j.tet.2011.10.026 Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity Paul A. Wender, Jeremy...

dissoluta), eleutherobin (from the coral Erythropodium caribaeorum), and the bryostatins (from the bryozoan Bugula neritina). Natural products sometimes have...

founder and chairman of BryoLogyx, which licensed a synthetic form of bryostatin-1 from Stanford University for the use in cancer immunotherapy and adjunctive...

Cancer Hemiasterlin (E7974) N/A Sponge Tripeptide Microtubules 0/3 Cancer Bryostatin 1 N/A Bryozoa Polyketide Protein Kinase C 0/38 Cancer, Alzheimers Pseudopterosins...

derivative of a dolastatin 10, a compound made by Dolabella auricularia. Bryostatins were first isolated from Bryozoa. Salinosporamides are derived from Salinispora...

development of a synthetically accessible protein kinase C activator with bryostatin-like activity. Journal of the American Chemical Society. 2009 Jun 10;131(22):7573-9...

enantioselectively, moieties found in products such as phorboxazole and bryostatin 1. Although the groups of E. Tagliavini[who?] and K. Mikami[who?] reported...

bronchoscope – bronchoscopy – bronchus – brostallicin – broxuridine – bryostatin 1 – buccal mucosa – budesonide – bupropion – burdock – Burkitt's leukemia...

carbonyl-olefin metathesis in their preparation of the C-ring fragment of bryostatin 1 In 2012, the Lambert group has reported a ring-opening metathesis of...

Bugula neritina used by the National Cancer Institute (NCI) to develop the bryostatin family of drugs used for treatment of cancer, HIV, Alzheimer's disease...

relationship with the bryozoan Bugula neritina. Certain antineoplastic agents, bryostatins 4 and 5, have been extracted from Aplidium californicum and are being...

research group discovered multiple anti-cancer compounds, including bryostatins, dolastatins/auristatins, and combretastatins, several of which advanced...

1998). "Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A". The...

GR; Hamdan, M; Mohamed, AN; Chelladurai, B; Mohammad, RM (May 1998). "Bryostatin 1 down-regulates mdr1 and potentiates vincristine cytotoxicity in diffuse...

"Identifying bryostatins and potential precursors from the bryozoan 'Bugula neritina'", Natural Product Research 19.5 (2005) 467–1 Halford, B. "The Bryostatins' Tale"...