killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling. In humans, the CD38 protein is encoded by the CD38 gene which...

among others, is an anti-cancer monoclonal antibody medication. It binds to CD38, which is overexpressed in multiple myeloma cells. Daratumumab was originally...

bronchitis (inflammation of the airways in the lungs). Isatuximab is an anti-CD38 mAb intended to treat relapsed or refractory multiple myeloma. It entered...

vulnerable to extracellular degradation by CD38 enzyme, which can be inhibited by compounds such as CD38-IN-78c. NMN is found in fruits and vegetables...

CD38-IN-78c is a drug which acts as a potent and selective inhibitor of the glycoprotein enzyme CD38. In animal studies it boosts levels of nicotinamide...

including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody. The most common adverse reactions include cytokine release...

much weaker catalyst than CD38. cADPR is required for regulation of Ca2+ in cells. Only CD38 hydrolyzed cADPR to ADPR. CD38 is widely expressed in tissues...

cells with the greatest self-renewal capacity and were shown to be CD34+ and CD38− cell fraction within the lineage-depleted cell population (LIn−). Human...

cytoplasm and occasionally on the cell surface; myeloma cells are often CD56, CD38, CD138, and CD319 positive and CD19, CD20, and CD45 negative. Flow cytometry...

contain enzymes such as CD38 and SARM1 that consumes NAD+. CD38 is an enzyme that triggers inflammatory responses and type II CD38 contains an ecto-NADase...

including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody. The US Food and Drug Administration (FDA) label prescribing...

Sanchez, L; Wang, Y; Siegel, DS (2016). "Daratumumab: a first-in-class CD38 monoclonal antibody for the treatment of multiple myeloma". J Hematol Oncol...

marrow with an abnormal immunophenotype (CD38+ CD56+ CD19−) mixed in with cells of a normal phenotype (CD38+ CD56− CD19+); in MGUS, on average more than...

ribose polymerase. ADPR is created from cyclic ADP-ribose (cADPR) by the CD38 enzyme using nicotinamide adenine dinucleotide (NAD+) as a cofactor. ADPR...

Because of the ability to reduce disulfide bonds, DTT can be used to denature CD38 on red blood cells. DTT will also denature antigens in the Kell, Lutheran...

including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody. In the EU it is indicated for the treatment of adults...

and ADPR are synthesized from NAD+ by the bifunctional ectoenzymes of the CD38 family (also includes the GPI-anchored CD157 and the specific, monofunctional...

Candidate genes include OXTR (polymorphisms in the oxytocin receptor), CD38, COMT, DRD4, DRD5, IGF2, AVPR1A and GABRB2. It is theorized that some of...

dexamethasone (CyBorD) with daratumumab added. Daratumumab, a monoclonal antibody to CD38, a protein that is expressed on plasma cells, was approved in US and EU for...

population often express features of activated CD8+ T cells, such as CD29, CD38, HLA-DR, CD45RO and CD95. Expression of CD25 was on the other hand decreased...

myeloma who have received at least four prior therapies including an anti-CD38 monoclonal antibody, a proteasome inhibitor, and an immunomodulatory agent...

angiogenesis, and integrin activation. CD31 on endothelial cells binds to the CD38 receptor on natural killer cells for those cells to attach to the endothelium...

like CD4 and CD135): LT-HSC: CD34−, CD38−, SCA-1+, Thy1.1+/lo, C-kit+, lin−, CD135−, Slamf1/CD150+ ST-HSC: CD34+, CD38+, SCA-1+, Thy1.1+/lo, C-kit+, lin−...

inconclusive. In a phase 1-2 open-label study treatment with CM313, a novel anti-CD38 monoclonal antibody, rapidly boosted platelet levels in adults with ITP by...

Fradette JJ, Gibbons DL (December 2019). "The Good, the Bad and the Unknown of CD38 in the Metabolic Microenvironment and Immune Cell Functionality of Solid...

et al. (July 2015). "Long-Lived Plasma Cells Are Contained within the CD19(-)CD38(hi)CD138(+) Subset in Human Bone Marrow". Immunity. 43 (1): 132–45. doi:10...

proteasome inhibitors, at least two immunomodulatory agents, and an anti-CD38 monoclonal antibody. In December 2020, selinexor was approved by the FDA...

source of primitive, undifferentiated stem cells (of type CD34-positive and CD38-negative). These cord blood cells can be used for bone marrow transplant...

CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e...

the biologist Graham J. Thompson and colleagues identified the genes OXTR, CD38, COMT, DRD4, DRD5, IGF2, GABRB2 as candidates "affecting altruism". The geneticist...